... no significant changes compared to the water-treated sample, demonstrating a remarkable skin tolerability. The employed regression model showed a good fit as well as adequate prediction and identified ceramide species associated with impaired skin barrier function. Furthermore, it was found that the relationship...

...Kathrin Hillmann; Tsenka Tomova-Simitchieva; Pauline Sophia Pinta; Zhile Xiong; Annette Moter; Varvara Kanti-Schmidt; Jan Kottner; Ulrike Blume-Peytavi Introduction: Regular use of leave-on skincare products has positive effects on the skin barrier and appears to influence the skin microbiome...

...Jeffrey Rajkumar; Neha Chandan; Peter Lio; Vivian Shi Background: The anatomic layers of the skin are well-defined, and a functional model of the skin barrier has recently been described. Barrier disruption plays a key role in several skin conditions, and moisturization is recommended as an initial...

... of IAD; however, the relationship between urinary pH and skin barrier disruption remains unclear. Objective: The aim of this study is to examine the effects of synthetic urine (s-urine) at various pHs on transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin surface pH. Methods: S...

...Sung Ha Lim; Eun Jung Kim; Chung Hyuk Lee; Gi Hyun Park; Kang Min Yoo; Sung Ju Nam; Kyong-Oh Shin; Kyungho Park; Eung Ho Choi Introduction: The stratum corneum (SC) is a skin barrier that consists of corneocytes, intercellular lipids, and corneodesmosomes. Ceramides are composed of sphingoid bases...

...Marika Quadri; Roberta Lotti; Laura Bonzano; Silvana Ciardo; Mario Bruno Guanti; Giovanni Pellacani; Carlo Pincelli; Alessandra Marconi Background: Emollients capable of restoring the skin barrier function would extend their role beyond basic maintenance therapy in atopic dermatitis (AD...

... such as atopic dermatitis and psoriasis are characterized by alterations of the skin barrier, often caused by injury and by bacterial infections. In the last years, non-pharmacological interventions have gained great importance in epidermis-related diseases. Xyloglucan (XG) is a polysaccharide that possesses...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Skin physiology Skin barrier Estradiol Menstrual cycle Skin moisture Skin smoothness Facial skin moisture...

... of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic acid bacteria ameliorate signs of aged and atopic skin, we investigated the effects of a topically applied Lactococcus lactis emulsion. Methods: In a blinded...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Lamellar granules Golgi apparatus Acylglucosylceramide ABCA12 Epidermis Skin barrier A typical lamellar granule (LG) with a diameter...

... led to improved skin barrier function. Conclusions: The suitability of the solvent-extracted wool wax for application in the preparation of cosmetics and dermatological products was demonstrated. A differential scanning calorimeter, DSC-821 (Mettler Toledo, Columbus, OH, USA), was used to determine...

...Eva K.B. Pfannes; Lina Weiss; Sabrina Hadam; Jessica Gonnet; Béhazine Combardière; Ulrike Blume-Peytavi; Annika Vogt The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption...

...Denise Falcone; Natallia Uzunbajakava; Renée Richters; Peter C.M. van de Kerkhof; Piet E.J. van Erp Background/Aims: Histamine iontophoresis is known to elicit itch and a wheal-and-flare reaction; however, its impact on the skin barrier and underlying compartments has not been thoroughly evaluated...

... of lipids and enzymes in the skin barrier. This slows down reorganisation of the lipid lamellae in the stratum corneum (SC). Methods: Skin barrier integrity was measured by morphometric analysis of the lipid lamellae in the SC after 4 weeks of treatment with a foam cream (active agent vs. placebo). Results...

...Simon G. Danby; Kirsty Brown; Tim Higgs-Bayliss; John Chittock; Lujain Albenali; Michael J. Cork Xerosis affects up to 75% of older people and develops as a result of a skin barrier defect. Emollients are widely used to treat xerosis; however, there is limited understanding of the differences...

...Russel M. Walters; Preeya Khanna; Melissa Chu; M. Catherine Mack The structure of the stratum corneum (SC) and the corresponding skin barrier develops from before birth up to about 4 years of age. Large subject-to-subject variability within an age group requires a large population to observe trends...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Penetration Skin barrier Skin physiology Antioxidants Free radicals Epidermal thickness The skin is not only the largest organ of the human body but also the barrier between...

... extract, as an example to illustrate this development. Accordingly, the existing data provide compelling evidence that Pycnogenol® intake does not only provide photoprotection, but may be used to (i) reduce hyperpigmentation of human skin and (ii) improve skin barrier function and extracellular matrix...

...Marianne Schario; Lena Lünnemann; Andrea Stroux; Anett Reisshauer; Torsten Zuberbier; Ulrike Blume-Peytavi; Natalie Garcia Bartels Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children...

...K. Heinrich; U. Heinrich; H. Tronnier The human skin barrier is an important part of the skin's intactness and its functionality is a precondition for healthy skin. Ingredients in cosmetic formulations, especially penetration enhancers, can influence this barrier function as they transport active...