...Marie Lodén; Per Boström; Marianne Kneczke Salicylic acid (SA) and urea are widely used in topical preparations. Using a simple tape stripping technique the effect on the binding forces within the stratum corneum and the skin absorption of SA and urea were studied. The degree of stratum corneum...

... Epidermis Cutaneous toxicity Skin irritants Bis-(P-chloroethyl) sulfide Cutaneous vesicant Salicylic acid Benzoic acid Abstract. The purpose of this study was to establish the validity of the stratified, cornified keratinocyte culture as a model for investigating cutaneous toxicities...

... ointment, respectively. Plasma levels of diflucortolone, cortisol and dehydroepiandrosterone (DHEA) were measured in both groups whereas plasma levels of salicylic acid were measured additionally in volunteers treated with Nerisalic. No differences, neither in percutaneous absorption of DFV nor in effects...

...S. de Mare; N. Calis; G. den Hartog; P.E.J. van Erp; P.C.M. van de Kerkhof The relevance of salicylic acid in dithranol creams was evaluated in a double-blind study. Patients with chronic plaque psoriasis were treated using a short-contact schedule for dithranol on an outpatient basis. A left-right...

... in corneocyte surface area could be used as a predictive measure for the efficacy of topical retinoids in man. Topical applications of all-trans retinoic acid gel (Aberel®), salicylic acid gel and the gel vehicle were made once daily for 4 weeks to skin of the lumbar region of healthy human volunteers...

...A. Otto; J.W. Wiechers; C.L. Kelly; J. Hadgraft; J. du Plessis In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) was investigated...

...M. Gloor; G. Haus; S. Keipert Objective: To compare the keratolytic activities of a drug-free hydrophilic microemulsion (ME) and a drug-free lipophilic ME with water, and with regard to the hydrophilic ME also with a 5% salicylic acid gel on the sole of the foot. Methods: Twenty healthy volunteers...

... 2003 Psoriasis Dithranol Vitamin D 3 analogues Corticosteroids Retinoids Tar Salicylic acid © 2003 S. Karger AG, Basel 2003 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

... the stratum corneum completely. For assessment of the model, 14 C-salicylic acid and 14 C-butyl salicylate were topically applied. Rapid and differentiated percutaneous absorption of both compounds were shown by urinary excretion data. For 14 C-salicylic acid the amount on the skin surface, in the stratum...

... xenobiotic interactions with corneocytes are assessed using reflectance colorimetry. It was used to evaluate comparatively the effects of ethanol and laurocapram at various dilutions. In addition, a 10% propylene-glycol-based gel supplemented with N-acetyl- L -cysteine, urea and salicylic acid in various...

... Accepted: March 15, 1999 Iontophoretic Transdermal Delivery of Salicylic Acid Dissolved in Ethanol-Water Mixture in Rats Teruo Murakamia Chie Iharaa Gakuji Kiyonakaa Ryoko Yumotoa Sadayuki Shigekib Yushikazu Ikutac Noboru Yataa, d aDepartment of Biopharmaceutics, Institute of Pharmaceutical Sciences...

.... The reason for such effects is not clear. We employed measures of transepidermal water loss (TEWL), squamometry and sequential corneosurfametry to explore the protective activity of a 0.05% RA cream at the level of the stratum corneum. Nonionic oil-in-water emulsions with or without 5% salicylic acid (SA...