...Baoping Li; Nanyang Li; Aik Han Goh; Haifeng Cao; Min Wang Irwin; Xunian Tong; Jingjing Wang; Xiaojie Wu; Jing Zhang; Dan Pu Introduction: SHR0302 is a highly selective JAK1 inhibitor. This study aimed to investigate the safety, tolerability, and pharmacokinetics of single and multiple-dose topical...

...N.-O. Hübner; J. Siebert; A. Kramer Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical...

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... on thyroid function has not been reported. This study was aimed at assessing the safety of topical methimazole used to treat pigmented lesions, without affecting thyroid hormones due to systemic delivery. The pharmacokinetics of methimazole, either applied in the form of a 5% topical formulation to facial...