...Malwina Zasada; Elzbieta Budzisz; Anna Erkiert-Polguj Background: Retinol influences the process of keratinization of the epidermis, which improves stratum corneum structure and reduces transepidermal water loss. It also significantly enhances mature skin by brightening hyperpigmentation...

...Véronique Goffin; Frédérique Henry; Claudine Piérard-Franchimont; Gérald E. Piérard The functional consequences of using topical retinol on skin have not been thoroughly studied so far. The aim of this open study was to compare two preparations containing either retinol or vitamin E, using...

...Salvador González; María Victoría Alcaraz; Florentina Díaz; Thomas J. Flotte; Ignacio Pérez de Vargas; Rox Anderson; Nik Kollias Objective: In order to assess the proliferative changes induced by all-trans retinoic acid (RA) and retinol (ROL), we have carried out a study of the DNA content of basal...

..., but is a very potent inhibitor of endogenous vitamin A metabolism in human epidermal cells. To further extend this observation, we studied the effect of 12 different retinoids on the metabolism of [ 3 H]retinol ([ 3 H]ROH) in HeLa cells, previously shown to produce constant levels of 3,4-didehydroretinol (ddROH...

...Hans Törmä; Eva Stenström; Eva Andersson; Anders Vahlquist For unknown reasons, the epidermal concentrations of retinol and its metabolite 3,4-didehydroretinol become characteristically changed during treatment with certain synthetic retinoids. In the present study we investigated [ 3 H]retinol...

...Hans Törmä; Anders Vahlquist The concentration of 3,4-didehydroretinol, an epidermal metabolite of retinol, is changed both in association with keratinizing disorders and during treatment with certain synthetic retinoids. To delineate further the factors regulation biosynthesis of 3,4-didehy...

...S. Seité; C. Bredoux; D. Compan; H. Zucchi; D. Lombard; C. Medaisko; A. Fourtanier Two double-blind studies versus vehicle were carried out to investigate the effects of a topically applied retinol plus vitamin C combination on epidermal and dermal compartments of aged or photoaged human skin...

.... The copresence of NAG with either of two retinoids, retinoic acid (RA) or retinol, exerted a synergistic effect on HA production. To investigate whether human HA synthase (HAS) genes were regulated by NAG or retinoids, total RNA extracted from cells treated with these agents was subjected to Northern blot...