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Keywords: Retinoids
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Journal Articles
Journal Articles
Skin Pharmacol Physiol (2016) 29 (2): 63–70.
Published Online: 23 March 2016
.... Arsenic trioxide (AsO 3 ) is used for the treatment of acute promyelocytic leukemia in combination with retinoids. As the latter are established treatment options in CTCL, we sought to evaluate the efficacy of AsO 3 for mono- and combination therapy in vitro. Analyses for apoptosis, cell cycle inhibition...
Journal Articles
Journal Articles
Skin Pharmacol Physiol (2012) 25 (5): 269–280.
Published Online: 27 July 2012
...P.A. Lehman; T.J. Franz Purpose: To develop a simple pharmacodynamic (PD) assay for the evaluation of the bioequivalence of topically applied retinoid products. Methods: Daily applications of products containing tretinoin or adapalene were made to the forearms of human subjects for up to 21 days...
Journal Articles
Skin Pharmacology (1997) 10 (1): 1–11.
Published Online: 01 April 2009
... clinical and histologic results of systematic trials, including the few studies of retinoid compounds other than tretinoin. Among the extensive data on topical tretinoin are long-term treatment results that provide evidence of ultrastructural changes. These histologic findings suggest that fundamental...
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Journal Articles
Skin Pharmacology (1988) 1 (2): 122–127.
Published Online: 31 March 2009
...M. Démarchez; J. Eustache; B. Shroot; H. Schaefer Retinoic acid and some selected analogs were tested to evaluate their effect on skin morphogenesis and toxicity in the chick embryo. Retinoids dissolved in dimethyl sulfoxide were injected at doses varying from 10 pmol to 10 µmol into the amniotic...
Journal Articles
Skin Pharmacology (1989) 2 (4): 181–186.
Published Online: 31 March 2009
... method for simultaneous determination of the 2 retinoids with a quantification limit of 2 ng/ml in plasma and 10 ng/g in total skin (epidermis and dermis). In hairless rats receiving orally 8 mg/kg acitretin once daily during 8 days, blood and skin samples were taken at different time points between 5...
Journal Articles
Skin Pharmacology (1994) 7 (3): 140–144.
Published Online: 31 March 2009
.... Isotretinoin Retinoids Topical application Plasma concentrations Cutaneous absorption Original Research Article Skin Pharmacol 1994;7:140-144 D. Santanaa H. Bunb J. Joachima A. Durand0 J.P. Reyniera Plasma Concentrations after Three Different Doses of Topical Isotretinoin 3 Laboratoire de pharmacie...
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Skin Pharmacology (1991) 4 (3): 150–153.
Published Online: 31 March 2009
.... It was shown that both retinoids are capable of inhibiting angiogenesis evoked by a human epidermoid carcinoma cell line (A431). Acitretin, but not etretinate, inhibited also angiogenesis induced by the spontaneously transformed murine keratinocyte cell line Pam 212 and by the established tumorigenic SKv cell...
Journal Articles
Skin Pharmacology (1991) 4 (3): 142–149.
Published Online: 31 March 2009
... Bollag, Richard Peck2 Pharmaceutical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland Key Words. Retinoids Immunomodulation Dermatology Oncology Abstract. The arotinoid temarotene (Ro 15-0778) and its metabolite Ro 14-6113 were examined in a variety of in vitro assays quantitating parameters...
Journal Articles
Skin Pharmacology (1991) 4 (4): 254–261.
Published Online: 31 March 2009
...James Varani; Gerard J. Gendimenico; Biren Shah; Douglas Gibbs; Robert J. Capetola; James A. Mezick; John J. Voorhees The purpose of these studies was to directly compare the pharmacologic effects of retinoids on cutaneous cells in vitro and in vivo. Previously, it was demonstrated that all-trans...
Journal Articles
Skin Pharmacology (1993) 6 (Suppl. 1): 17–23.
Published Online: 31 March 2009
...Hans Schaefer Topical retinoids are therapeutically active at low pharmaceutical concentrations, i.e. in essence lack of penetration is not a problem. Thus studies on the cutaneous pharmacokinetics focus on the distribution pattern in the skin, the penetration pathways, the cutaneous metabolism...
Journal Articles
Skin Pharmacology (1993) 6 (Suppl. 1): 24–34.
Published Online: 31 March 2009
...Gerard J. Gendimenico; James A. Mezick Retinoids exert profound pleiotropic effects in skin, affecting many aspects of cell differentiation and proliferation. For this reason, retinoids have prominent pharmacological effects on major skin cells (keratinocytes, dermal fibroblasts, melanocytes...
Journal Articles
Skin Pharmacology (1993) 6 (Suppl. 1): 45–52.
Published Online: 31 March 2009
...Peter Buchan In current cutaneous retinoid therapy systemic exposure is low and the risk of teratogenesis appears to be limited. However, new indications, altered posologies and the introduction of new synthetic retinoids demand continuous assessment of the teratogenic risk. Teratogenicity testing...
Journal Articles
Skin Pharmacol Physiol (2008) 21 (4): 211–217.
Published Online: 29 May 2008
... to in the content or advertisements. Claudin 2 Tight junction Retinoids Keratinocytes Epidermis Original Paper Skin Pharmacol Physiol 2008;21:211 217 DOI: 10.1159/000135637 Received: April 13, 2007 Accepted after revision: December 8, 2007 Published online: May 29, 2008 Claudin 2 mRNA and Protein...