...Farhaan Hafeez; Howard Maibach Background/Aim: Skin occlusion can increase the hydration of the stratum corneum up to 50%, which can have substantial effects on the percutaneous absorption of penetrants by altering skin barrier physiology. Though occlusion is widely utilized to enhance...

... transdermal drug delivery Diffusion Occlusion Rhesus monkey Permeability coefficient Abstract. Transcutaneous chemical collection is a novel method for noninvasive collec­ tion and measurement of body exposure to chemicals using a transcutaneous collection device (TCD) consisting of a circular...

...Simon M. Jackson; Man Mao-Qiang; Peter M. Elias; Kenneth R. Feingold Occlusion of the skin with a water-vapor-impermeable membrane following disruption of the permeability barrier prevents the epidermal changes which lead to the restoration of barrier function, suggesting that water transit could...

... occluded versus unoccluded conditions. Human abdominal skin samples were mounted on Dianorm® Teflon® macro 1 cells and Franz diffusion cells which represented occluded or unoccluded conditions, respectively. Our data show that occlusion increased the permeation of citropten (lipophilic compound) 1.6 times...

...E. Berardesca; H.I. Maibach The effects of occlusion on skin function are described and reviewed. Occlusion seems to be not only a device applied on the skin surface, but, under certain conditions, a powerful treatment capable of inducing several changes on epidermal metabolism, skin flora, sweat...

...C. Pellanda; C. Strub; V. Figueiredo; T. Rufli; G. Imanidis; C. Surber Background/Aims: Occlusion by covering the skin with an impermeable wrap enhances skin hydration, affects drug absorption and can induce the formation of a drug reservoir within the stratum corneum. This is desired in local...

...C.P. Glade; C.J.M. van der Vleuten; P.E.J. van Erp; P.C.M. van de Kerkhof Clearance and relapse characteristics of clobetasol lotion under hydrocolloid occlusion once weekly versus clobetasol ointment twice daily were assessed in a comparative flow cytometric study. Quantitative analysis of markers...

...P. Schäfer; C. Bewick-Sonntag; M.G. Capri; E. Berardesca Skin occlusion is a condition encountered with various articles as part of everyday life and resulting changes in skin barrier physiology often remain unnoticed. In the present study we aimed to understand the impact of absorbent feminine...

...Hongbo Zhai; Howard I. Maibach Skin occlusion produces profound changes, including hydration status, barrier permeability, epidermal lipids, DNA synthesis, microbial flora, and numerous molecular and cellular processes. It often, but not always, increases percutaneous absorption of applied...

...J.W. Fluhr; S. Lazzerini; F. Distante; M. Gloor; E. Berardesca Purpose of the Study: We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time. Materials...