...Jarika Kaewbanjong; Thanaporn Amnuaikit; Eliana B. Souto; Prapaporn Boonme Aim: Antifungal activity, skin permeation and skin retention of water-in-oil microemulsion (ME) and microemulsion-based gel (MBG) containing clotrimazole (CTZ) were evaluated in comparison to a conventional CTZ cream...

..., and on the other hand, a microemulsion (ME-PG) system was developed. Both were compared to the standard formulation without an enhancer molecule. For all 3 preparations, the penetration of the peptides in ex vivo human skin was investigated. This allows statements to be made regarding dermal penetration...

... or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative...

... a challenge to find an optimized way of drug administration. The transdermal route has attracted interest as a promising way to advance the delivery of these drugs. The objective of this review is to summarize the level of research of microemulsions as colloidal carrier for dermal peptide drug delivery...

...E. Escribano; M. Obach; M.I. Arévalo; A.C. Calpena; J. Domenech; J. Queralt We developed a fast-acting, topical, 4% (w/w) amethocaine microemulsion and tested its in vitro permeation in isolated human skin. Comparison with a commercial amethocaine gel (Ametop ® ) was performed using Franz diffusion...

... DNA vaccine Microemulsion Skin Pharmacology andApplied Skin Physiology Review Skin Pharmacol Appl Skin Physiol 2003;16:271 282 DOI: 10.1159/000072067 Received: March 24, 2003 Accepted: April 25, 2003 Topical Vaccination of DNA Antigens: Topical Delivery of DNA Antigens M.J. Choi H.I. Maibach...

...M. Gloor; G. Haus; S. Keipert Objective: To compare the keratolytic activities of a drug-free hydrophilic microemulsion (ME) and a drug-free lipophilic ME with water, and with regard to the hydrophilic ME also with a 5% salicylic acid gel on the sole of the foot. Methods: Twenty healthy volunteers...