... investigated the link between flare and itch using 3 models of itch. Methods: Skin provocations with histamine, capsaicin, and cowhage were performed in 31 subjects. Itch was quantified using the visual analog scale. Flare was assessed using laser speckle contrast imaging (LSCI) and digital photography...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Arthritis Dry skin Mast cells Histamine Thymic stromal lymphopoietin Reactive oxygen species Glucocorticoids Rheumatoid arthritis (RA...

...Denise Falcone; Natallia Uzunbajakava; Renée Richters; Peter C.M. van de Kerkhof; Piet E.J. van Erp Background/Aims: Histamine iontophoresis is known to elicit itch and a wheal-and-flare reaction; however, its impact on the skin barrier and underlying compartments has not been thoroughly evaluated...

... suggest that histamine stimulates melanogenesis in vitro, we determined here whether topical histamine stimulates repigmentation in patients with stable, nonsegmental vitiligo. Methods: A total of 23 otherwise normal volunteers with vitiligo, including 14 males and 9 females aged 6-59 years (mean age 29.2...

...T. Yoshitake; S. Ijiri; S. Yoshitake; K. Todoroki; H. Yoshida; J. Kehr; H. Nohta; M. Yamaguchi Aim: To develop a sensitive and selective liquid-chromatographic method for the determination of histamine in microdialysis samples from guinea pig skin following allergenic provocation. Methods...

..., saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded. Results: There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10 –5 and 10 –6 mol/l) between...

...Elke Weisshaar; Clemens Forster; Markus Dotzer; Gisela Heyer We investigated the antipruritic effect of a 15-min application of dimethindene maleate (Fenistil® gel) and other local analgesics (Optiderm®, EMLA®, Xylocain® ointment 5%) on subsequent focal histamine stimulus (20 mC) given...

...Portia Goldsmith; Christopher Bunker; Tabi Leslie; John Foreman; Pauline M. Dowd The effect of topical application of clobetasol propionate ointment (0.05% w/v) on the vascular changes induced by intradermal injections of histamine, calcitonin gene-related peptide, substance P, endothelin-1...

...Kayo Okaham; Teruo Murakami; Shoso Yamamoto; Noboru Yata In vivo histamine release in cutaneous allergic reactions was chronologically examined using the skin microdialysis technique. Antigen challenge was made in ovalbumin-sensitized guinea pigs 1 h after the implantation of the microdialysis...

...L.R. Lever; S. Hill; P.J. Dykes; R. Marks Double-blind, placebo-controlled studies were performed to assess the effect of 0.1 % dimetindene gel on the itch threshold to intracutaneous histamine and on the weal and flare reaction after intracutaneous injection of histamine in normal volunteer...

... Contact sensitivity IgE antibody Mast cells Serotonin Histamine T cells Nude mice IL-3 Skin Pharmacol 199l;4(suppl 1):25 42 Serotonin Initiation of Delaycd-Typc Hypersensitivity: Mediation by a Primitive Thy-1+Antigen-Specific Clone or by Specific Monoclonal IgE Antibody1 Philip IV. Askena.se...

...C.E.H. Grattan Circulating histamine-releasing factors have been identified in the serum and plasma of chronic-urticaria patients by in vivo skin testing and in vitro histamine release from heterologous mixed leukocytes. Quantitative mast cell studies of serum skin test biopsies and electron...

...M.L. Coulson; N.A. Hayes; J.C. Foreman Histamine-induced changes in blood flow in normal human skin were assessed by laser-Doppler velocimetry using 2 lasers of different wavelengths: 780 nm infrared and 633 nm helium-neon. The visible flare response in skin was also measured by planimetry. Laser...

...Martin K. Church; Yoshimichi Okayama; Suhad El-Lati Mast cells of the human skin not only release mediators following immunological activation, but may also be stimulated to release histamine by the neuropeptides substance P, vasoactive intestinal polypeptide and somatostatin or by other basic...

..., instructions or products referred to in the content or advertisements. Anthralin inflammation Dithranol Histamine Antihistamine Terfenadine H 1 -receptor antagonist Original Research Article Skin Pharmacol 1992;5:25-28 E.L. Speight C.M. Lawrence Department of Dermatology, Royal Victoria Infirmary...

... of antihistamines that totally abolished a histamine weal only partly reduced urticarial weals (therefore by inference also of the associated pruritus). Additional therapy aimed at pruritogenic mediators other than histamine would be expected to improve urticarial pruritus. 2 01 1991 19 07 1991 31 3...

... are discussed. Histamine induces itch upon intradermal injection, but urticaria is the only itching dermatosis which is significantly relieved by antihistamines. Serotonin is much weaker than histamine in provoking itch upon intradermal injection. Serotonin acting in synergism with prostaglandins may cause itch...

... patients have higher serum levels of parathyroid hormone (PTH) than nonpruritic patients, subsequent studies do not support a role for PTH as a peripheral itch mediator. Experimental itching induced by intracutaneous histamine injections is significantly stronger in patients with uremic itching, indicating...

...Chris Anderson; Thomas Andersson; Rolf G.G. Andersson Microdialysis, a new bioanalytical sampling technique, enables the measurement of substances in the extracellular space. This study investigates the use of the technique in the in vivo measurement of histamine levels in human skin. Microdialysis...

... following intracutaneous injections of SP and histamine were studied in 10 healthy volunteers. The only change in itch responsiveness observed was a significant prolongation of itch latency following SP when preceded 10 min earlier by a CGRP injection. No influence on flare and weal was observed. 18 06...