...Dongyun Lei; Li Ye; Si Wen; Junling Zhang; Litao Zhang; Mao-Qiang Man Background: The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet (UV) irradiation. UV irradiation, mainly UVB at wavelength of 280–315 nm, can alter several epidermal functions...

... demonstrated that disruption of the epidermal permeability barrier increases expression levels of proinflammatory cytokines and the density of Langerhans cells in the epidermis and mast cells in the dermis, in addition to elevating circulating levels of proinflammatory cytokines [ 67‒71 ]. A defective...

...Masaki Yoshida; Kyong-Oh Shin; Sora Muraoka; Yerim Choi; Jae-Ho Park; Soo-Hyun Park; Jin-Taek Hwang; Kyungho Park; Yoshikazu Uchida Introduction: The outermost layer of the skin, the epidermis, is directly exposed to external stress (e.g., irradiation, allergens, and chemicals). Changes...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epidermis Inflammation Irritation...

...Philip Wertz In the mid-1950s and 1960s, transmission electron microscopes became widely available, leading to many studies of the ultrastructure of various tissues including the epidermis. Most of these studies involved tissue fixation with formaldehyde and postfixation with osmium tetroxide...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Aging Epidermis Skin Transepidermal water loss pH Physical forces Quantification of skin barrier characteristics is a cornerstone...

... 2013 Lipids in the epidermis are packaged into small secretory organelles called lamellar granules. These granules secrete their contents into the intercellular spaces at the boundary between the uppermost granular cells and the bottom of the stratum corneum. These initially extruded lipids...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epidermis Inflammation 5-Lipoxygenase...

... Department of Dermatology, University Hospital Nijmegen, The Netherlands The Role of Epidermal Proliferation in the Pathogenesis of Psoriasis Key Words Epidermis Keratinization Psoriasis Abstract The micromorphological appearance of the psoriatic lesion is characterized by cutaneous inflammation, epidermal...

... also demonstrated known variations in epidermal thickness by body site. Further development is needed to obtain measurements that are fully representative of the epidermis. © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

..., are 232 (Wistar rats) and 222 (Sprague-Dawley rats). Topical application of RA (1 mg) on 4-day-old rats induces a 3.3-and 3.9-fold increase in epidermis microsomal RA metabolism. A 4.6- to 8.1-fold increase is observed 24 h after topical application of 3-methylcholanthrene (0.5 mg). By contrast...

...Gerald W. De Vries; Lawrence D. Amdahl; Nicholas Lowe; Larry A. Wheeler Β-Adrenergic receptor hyporesponsiveness has been observed in psoriasis and after exposure of epidermis to phorbol esters. It was the purpose of our studies to determine if forskolin, which is known to act synergistically...

... in keratin expression and cornified envelope formation. Our results suggest that nicotine at concentrations up to 100 µg/ml is not an irritant but may induce cornification of the skin. Cell Culture Keratinocytes Epidermis Smoke 2 02 1993 25 05 1993 31 3 2009 © 1994 S. Karger AG...

... Epidermis Cutaneous toxicity Skin irritants Bis-(P-chloroethyl) sulfide Cutaneous vesicant Salicylic acid Benzoic acid Abstract. The purpose of this study was to establish the validity of the stratified, cornified keratinocyte culture as a model for investigating cutaneous toxicities...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epidermis Leukotrienes Slow...

..., but only marginally affected the retinol values. We conclude that the increase in retinol and marked reduction in 3,4-didehydroretinol concentrations in epidermis especially during treatment with 13- cis -retinoic acid are most likely due to diminished conversion of retinol to 3,4-didehydroretinol...

...-droretinol, keratinocytes from three different layers of normal epidermis were prepared by trypsinization and incubated with [ 3 H]-retinol for 20 h. Cell-bound [ 3 H]-retinol and 3,4-[ 3 H]-didehydroretinol were separated by high-performance liquid chromatography. The results indicate that the uptake...

...P. Treffel; B. Gabard A method has been developed which simultaneously compares the inhibition of an inflammation induced by a methyl nicotinate assay with the concentration of drug in the human epidermis determined in vitro following topical application of two 10% ibuprofen formulations...

... of Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, Calif., USA Key Words Epidermis Stem cell Tissue regeneration Gene therapy Stem cell isolation neering. Here we focus on epidermal stem cells as the basis for tissue engineered epidermis and also discuss...

... where its expression is restricted to the leaky epithelium. Immunohistochemical staining revealed claudin 2 staining in the granular layer of adult epidermis. Analysis of Western blots revealed bands corresponding to the molecular weight of claudin 2 in Madin-Darby canine kidney II cells, human kidney...