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Keywords: Differentiation
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Journal Articles
Skin Pharmacol Physiol (2021) 34 (5): 246–252.
Published Online: 29 April 2021
..., while ceramides (Cer) produced from SM on plasma membranes serve as a lipid mediator that regulates cell proliferation, differentiation, and apoptosis. In the skin, SM also is a precursor of Cer, an important constituent of epidermal permeability barrier. We investigated the role of epidermal SM...
Journal Articles
Journal Articles
Skin Pharmacol Physiol (2013) 27 (1): 36–46.
Published Online: 06 August 2013
... the effects of HDACi on healthy human primary skin cell cultures and three-dimensional epidermal models. In general, HDACi exert an effect on both the epidermal morphology and differentiation process of human skin. The latter is manifested through cell cycle arrest, disorganization of the basal layer...
Journal Articles
Journal Articles
Skin Pharmacology and Applied Skin Physiology (1997) 10 (5-6): 265–274.
Published Online: 01 April 2009
..., and lithocholate at 2 µ M. The glycine and taurine conjugates of bile acids were significantly less effective inhibitors of growth, as was the sulfate conjugate of lithocholic acid. DOC and chenodeoxycholate at 25-50 µ M enhanced the differentiation-specific increase in particulate transglutaminase activity...
Journal Articles
Skin Pharmacology (1994) 7 (1-2): 90–93.
Published Online: 31 March 2009
.... trichilemmal carcinoma, malignant pilo-matricoma) have been described. In the present review we propose the classification of pilosebaceous tumors by degree and by direction of differentiation and by histological configuration. Three different histological patterns have to be distinguished: tumors with central...
Journal Articles
Skin Pharmacology (1994) 7 (1-2): 27–32.
Published Online: 31 March 2009
... studies of two glycoproteins characteristic for undifferentiated (gp 38) and for differentiated (gp 80) keratinocytes revealed higher synthesis levels for gp 80 and lower levels for gp 38 in VHK as compared to normal epidermal keratinocytes in vitro. These findings suggest a distinct morphologic...
Journal Articles
Skin Pharmacology (1993) 6 (Suppl. 1): 24–34.
Published Online: 31 March 2009
...Gerard J. Gendimenico; James A. Mezick Retinoids exert profound pleiotropic effects in skin, affecting many aspects of cell differentiation and proliferation. For this reason, retinoids have prominent pharmacological effects on major skin cells (keratinocytes, dermal fibroblasts, melanocytes...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2002) 15 (6): 393–400.
Published Online: 16 December 2002
... Differentiation W Inflammation Abstract Dithranol, although a time-honoured treatment and from the beginning of the previous century still going strong, remains an empirical treatment. There is growing evidence that the biochemical basis for the mechanism of action of dithranol at the molecular level is related...
Journal Articles
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2002) 15 (4): 262–269.
Published Online: 05 September 2002
... counteraction to this well-known irritation. Therefore, we studied the effect of single and repeated applications of dithranol on normal human skin. Besides a clinical evaluation, we studied aspects of epidermal proliferation, differentiation and inflammation. On day 2, after single dithranol challenge, we...
Journal Articles
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2000) 13 (1): 17–30.
Published Online: 12 February 2000
.... Transglutaminase Cornified envelope Keratinocyte Differentiation Cross-linking Isopeptide bond Apoptosis Original Research Article Skin Pharmacol Appl Skin Physiol 2000;13:17 30 Received: June 8, 1999 Accepted: June 9, 1999 Transglutaminase Reactivity of Human Involucrin Adam Lamberta Meena Ekambarama...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (1999) 12 (6): 317–325.
Published Online: 22 October 1999
...]thymidine incorporation. On the other hand, this substance enhanced synthesis of keratin K1, a potent marker of differentiation in keratinocytes, at 1–100 μg/ml in low calcium (0.1 m M ) or high calcium medium (1.25 m M ). Moreover, the formation of cornified envelope, another potent marker...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (1999) 12 (4): 174–181.
Published Online: 17 July 1999
...J.M. Mommers; A.C. ter Meulen; P.E.J. van Erp; P.C.M. van de Kerkhof In the last few years, tacalcitol (1α,24-dihydroxy vitamin D 3 , TV-02) has become widely available for the topical treatment of psoriasis. Several studies documented its effect on epidermal differentiation, inflammation...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (1998) 11 (3): 152–160.
Published Online: 01 October 1998
...Thomas Mammone; Ken Marenus; Daniel Maes; Richard A. Lockshin The terminal differentiation of human epidermal keratinocytes is a complex morphological and biochemical shift from a mitotically active cell to an inert protein cross-linked envelope. This transition is a clearly predetermined cell...