..., while ceramides (Cer) produced from SM on plasma membranes serve as a lipid mediator that regulates cell proliferation, differentiation, and apoptosis. In the skin, SM also is a precursor of Cer, an important constituent of epidermal permeability barrier. We investigated the role of epidermal SM...

... with antioxidant and anti-inflammatory properties, induces normal epidermal keratinocyte differentiation and suggested its possible usefulness for the treatment of psoriasis [ 1 ]. Objectives: To investigate the effect of delphinidin (0-20 μ M ; 2-5 days) on psoriatic epidermal keratinocyte differentiation...

... the effects of HDACi on healthy human primary skin cell cultures and three-dimensional epidermal models. In general, HDACi exert an effect on both the epidermal morphology and differentiation process of human skin. The latter is manifested through cell cycle arrest, disorganization of the basal layer...

... supplemented with 3% charcoal-stripped fetal calf serum and 0.3 m M Ca 2+ . Proliferation was measured by the dimethylthiazolyl-diphenyl-tetrazolium-bromide assay. Then differentiation was determined in the same culture, performing a cell ELISA for transglutaminase type 1. All-trans-RA, 9-cis-RA and CD2809 had...

..., and lithocholate at 2 µ M. The glycine and taurine conjugates of bile acids were significantly less effective inhibitors of growth, as was the sulfate conjugate of lithocholic acid. DOC and chenodeoxycholate at 25-50 µ M enhanced the differentiation-specific increase in particulate transglutaminase activity...

...Gerard J. Gendimenico; James A. Mezick Retinoids exert profound pleiotropic effects in skin, affecting many aspects of cell differentiation and proliferation. For this reason, retinoids have prominent pharmacological effects on major skin cells (keratinocytes, dermal fibroblasts, melanocytes...

.... trichilemmal carcinoma, malignant pilo-matricoma) have been described. In the present review we propose the classification of pilosebaceous tumors by degree and by direction of differentiation and by histological configuration. Three different histological patterns have to be distinguished: tumors with central...

... studies of two glycoproteins characteristic for undifferentiated (gp 38) and for differentiated (gp 80) keratinocytes revealed higher synthesis levels for gp 80 and lower levels for gp 38 in VHK as compared to normal epidermal keratinocytes in vitro. These findings suggest a distinct morphologic...

.... Psoriasis Dithranol Immunohistochemistry Proliferation Differentiation Inflammation Skin Pharmacology andApplied Skin Physiology Original Research Article Skin Pharmacol Appl Skin Physiol 2002;15:393 400 Received: Feb. 19, 2001 DOI: 10.1159/000066450 Accepted after revision: Dec. 18, 2001...

...-inflammatory processes and as such constitute an antipsoriatic principle. It is attractive to speculate that in psoriasis the induction of anti-inflammatory responses is defective. Following repeated applications of dithranol, a more uniform course of proliferation, differentiation and inflammation markers...

... counteraction to this well-known irritation. Therefore, we studied the effect of single and repeated applications of dithranol on normal human skin. Besides a clinical evaluation, we studied aspects of epidermal proliferation, differentiation and inflammation. On day 2, after single dithranol challenge, we...

...Arno Pol; Mieke Bergers; Fred van Ruissen; Rolph Pfundt; Joost Schalkwijk Established treatments for psoriasis act ei-ther on hyperproliferation, inflammation, aberrant epidermal differentiation or a combination of these aspects of the disease. Potential new drugs for treatment of psoriasis...

.... Transglutaminase Cornified envelope Keratinocyte Differentiation Cross-linking Isopeptide bond Apoptosis 12 2 2000 Original Research Article Skin Pharmacol Appl Skin Physiol 2000;13:17 30 Received: June 8, 1999 Accepted: June 9, 1999 Transglutaminase Reactivity of Human Involucrin Adam Lamberta...

...]thymidine incorporation. On the other hand, this substance enhanced synthesis of keratin K1, a potent marker of differentiation in keratinocytes, at 1–100 μg/ml in low calcium (0.1 m M ) or high calcium medium (1.25 m M ). Moreover, the formation of cornified envelope, another potent marker...

...J.M. Mommers; A.C. ter Meulen; P.E.J. van Erp; P.C.M. van de Kerkhof In the last few years, tacalcitol (1α,24-dihydroxy vitamin D 3 , TV-02) has become widely available for the topical treatment of psoriasis. Several studies documented its effect on epidermal differentiation, inflammation...

...Thomas Mammone; Ken Marenus; Daniel Maes; Richard A. Lockshin The terminal differentiation of human epidermal keratinocytes is a complex morphological and biochemical shift from a mitotically active cell to an inert protein cross-linked envelope. This transition is a clearly predetermined cell...