... procollagen and matrix metalloproteinase-1 (MMP-1) in ultraviolet B (UVB)-irradiated neonatal normal human dermal fibroblasts (NHDFn). Using nonlinear optical imaging techniques, we visualized quantitative and qualitative changes of collagen fibers by DAA treatment in human skin equivalent models. Results...

...Audrey Gueniche; Isabelle Castiel-Higounenc Background: Glucosamine sulphate (GS) is essential in the biosynthesis of glycolipids, glycoproteins, glycosaminoglycans (GAGs), hyaluronate, and proteoglycans. Connective tissues primarily contain collagen and proteoglycans and play an important role...

... regulation of cellular processes in the wound, which, in turn, affect the wound healing process. However, the effects of pH on the collagen breakdown component of wound healing have yet to be investigated. Therefore, we investigated the induction of accelerated collagen breakdown by pH imbalance in the skin...

... (FRs) in the skin is studied. Additionally, the influence of IR radiation at high temperatures in the degradation of skin collagen is evaluated. In both experiments the protective effect against IR radiation of phospholipid nanostructures (bicosomes) incorporating β-carotene (Bcb) is also evaluated...

...Phuong Le Vu; Ryo Takatori; Taku Iwamoto; Yutaka Akagi; Hideo Satsu; Mamoru Totsuka; Kazuhiro Chida; Kenji Sato; Makoto Shimizu Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear...

... A irradiation (IRA) produces free radicals, triggers major changes in the expression of the type I collagen and elastin network, impairs the dermal-epidermal junction, upregulates several matrix metalloproteinases and has an impact on the expression of key genes of the extracellular matrix. We conclude...

... taken for complete epithelization as well as levels of various parameters of the wound’s granulation tissue. The collagen solubility pattern, glycohydrolase activity, and histopathology of the granulation tissue were also analyzed. The antioxidant status during wound healing was monitored continuously...

...Yann F. Mahé; Bruno Buan; Bruno A. Bernard It has been previously reported that minoxidil inhibits the activity of lysyl hydroxylase (LH), an enzyme which catalyzes the formation of hydroxylysine, which is necessary for proper maturation of collagen at the transcriptional and enzymatic levels...

... to UV radiations. Then, human skin explants were maintained alive in organ culture for 3 days. Free radical modulation was analysed by hydroperoxide assay. Epidermal (involucrin, cell proliferation, stratum corneum lipids) and dermal changes (elastic fibres and collagen) were studied. Analysis of ex...

... and distribution. Biochemical analysis revealed a significant decrease in collagen content per unit area and mass in Sq-OOH-treated skin, whereas no changes per unit area and decrease in collagen per unit mass were observed in UVB-irradiated skin. As for glycosaminoglycan (GAG) content per unit area, significant...