.... An experimental lateral MD setup was used to determine the influence of percutaneous skin penetration characteristics of an active ingredient with different lipophilic and hydrophilic characteristics. Therefore, hydrophilic caffeine and lipophilic LIP1, which have an identical molecular weight but different...

... penetration studies. In study B, the lipophilic differences of the active ingredients and its influences on the penetration was tested using hydrophilic caffeine and lipophilic LIP1 as model compounds, which have an identical molecular weight with different lipophilic characteristics. It is assumed...

...-stimulating agents. Materials and Methods: Using the hanging drop method, DPCs self-organized into spheroid shape, mirroring the three-dimensional (3D) structure of the DP in vivo. DP analogs were treated with established substances against AGA (minoxidil and caffeine) compared to HIF-1α-stimulating agents...

...Jörn Michael Völker; Nadine Koch; Maike Becker; Adolf Klenk Caffeine, particularly after ingestion, is well known to exert various pharmacological effects. A growing body of evidence implicates the ingestion of caffeine with beneficial effects on several diseases. The easy penetration of caffeine...

.... It was tested if the varnish blocks the API (caffeine) on completely covered areas and if adjacent areas show increased penetration. Furthermore, lateral diffusion of the API was investigated. After 20 h, the skin layers were separated by tape stripping and heat separation. The tissue samples were homogenized...

...Eman Abd; Heather A.E. Benson; Michael S. Roberts; Jeffrey E. Grice Background/Aims: This study aimed to investigate transfollicular delivery enhancement of caffeine from nanoemulsion formulations incorporating oleic acid (OA) and eucalyptol (EU) as chemical penetration enhancers. Methods: Caffeine...

... time, a significant (p = 0.002) difference was found among all groups, but comparisons with fresh skin were not significant. Does glycerol have a cryoprotective effect? The steady-state flux and lag time of DEP and caffeine were measured through human skin stored at -85°C for up to 12 months...

...A. Herman; A.P. Herman Caffeine is being increasingly used in cosmetics due to its high biological activity and ability to penetrate the skin barrier. This alkaloid is frequently used as a hydrophilic model substance in human and animal skin penetration as well as different synthetic membrane using...

... study applies imaging techniques (multiphoton excitation fluorescence microscopy) and in vitro percutaneous penetration of caffeine under four different storage conditions using skin samples from the same donors: fresh skin, skin kept at –20°C for 3 weeks (with or without the use of polyethylene glycol...

...S. Trauer; J. Lademann; F. Knorr; H. Richter; M. Liebsch; C. Rozycki; G. Balizs; R. Büttemeyer; M. Linscheid; A. Patzelt The Organization for Economic Cooperation and Development (OECD) recommends caffeine as a reference substance for in vitro skin absorption tests using Franz diffusion cells (FDC...

... on both sides of the flap, one with normal blood flow and the other with a reproducible blood flow decrease (60%) obtained by ligation of one pedicle. 14 C-labelled compounds, progesterone (lipophilic), caffeine (amphiphilic) and urea (hydrophilic) were applied in ethanolic solution during 4 h on the two...

... whereas that of caffeine (amphiphilic compound) remained unchanged. This lack of penetration enhancement under occluded conditions has also been observed by other authors, especially concerning hydrophilic and slightly lipophilic molecules. Our results support the view that occlusion does not necessarily...

... obtained, must be verified. The reproducibility of 3 industrial models – EpiDerm ® , Episkin ® and SkinEthic ® – was tested regarding the permeation and skin absorption of 3 topically applied compounds (with a large range of physicochemical properties): lauric acid, caffeine and mannitol. For all...

.... Leclaire F. Benech-Kieffer L Oréal Research, Aulnay-sous-Bois, France Key Words Human skin model W EpiDerm® W Episkin® W Percutaneous absorption W Dynamic diffusion cell W Benzoic acid W Caffeine W Mannitol Abstract Human skin models, such as EpiDerm® and Episkin®, are not easily mounted into static...

...S. Nicoli; V. Amoretti; P. Colombo; P. Santi The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were...