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1-15 of 15
Keywords: Caffeine
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Journal Articles
Lateral Dermal Penetration Is Dependent on the Lipophilicity of Active Ingredients
Available to Purchase
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2022) 35 (4): 235–246.
Published Online: 16 February 2022
.... An experimental lateral MD setup was used to determine the influence of percutaneous skin penetration characteristics of an active ingredient with different lipophilic and hydrophilic characteristics. Therefore, hydrophilic caffeine and lipophilic LIP1, which have an identical molecular weight but different...
Journal Articles
Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis
Available to Purchase
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2021) 34 (4): 203–213.
Published Online: 21 May 2021
... penetration studies. In study B, the lipophilic differences of the active ingredients and its influences on the penetration was tested using hydrophilic caffeine and lipophilic LIP1 as model compounds, which have an identical molecular weight with different lipophilic characteristics. It is assumed...
Journal Articles
HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth
Available to Purchase
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2021) 33 (6): 309–316.
Published Online: 16 December 2020
...-stimulating agents. Materials and Methods: Using the hanging drop method, DPCs self-organized into spheroid shape, mirroring the three-dimensional (3D) structure of the DP in vivo. DP analogs were treated with established substances against AGA (minoxidil and caffeine) compared to HIF-1α-stimulating agents...
Journal Articles
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2020) 33 (3): 153–169.
Published Online: 29 June 2020
...Jörn Michael Völker; Nadine Koch; Maike Becker; Adolf Klenk Caffeine, particularly after ingestion, is well known to exert various pharmacological effects. A growing body of evidence implicates the ingestion of caffeine with beneficial effects on several diseases. The easy penetration of caffeine...
Journal Articles
Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin
Available to PurchaseAnna Lena Klein, Markus Lubda, Paniz Akbarzadeh Taghavi, Jürgen Lademann, Ingeborg Beckers, Jörg von Hagen, Harald Kolmar, Alexa Patzelt
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2020) 33 (2): 117–126.
Published Online: 11 February 2020
.... It was tested if the varnish blocks the API (caffeine) on completely covered areas and if adjacent areas show increased penetration. Furthermore, lateral diffusion of the API was investigated. After 20 h, the skin layers were separated by tape stripping and heat separation. The tissue samples were homogenized...
Journal Articles
Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2018) 31 (5): 252–260.
Published Online: 12 July 2018
...Eman Abd; Heather A.E. Benson; Michael S. Roberts; Jeffrey E. Grice Background/Aims: This study aimed to investigate transfollicular delivery enhancement of caffeine from nanoemulsion formulations incorporating oleic acid (OA) and eucalyptol (EU) as chemical penetration enhancers. Methods: Caffeine...
Journal Articles
Effect of Frozen Human Epidermis Storage Duration and Cryoprotectant on Barrier Function Using Two Model Compounds
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2016) 29 (1): 31–40.
Published Online: 26 November 2015
... time, a significant (p = 0.002) difference was found among all groups, but comparisons with fresh skin were not significant. Does glycerol have a cryoprotective effect? The steady-state flux and lag time of DEP and caffeine were measured through human skin stored at -85°C for up to 12 months...
Journal Articles
Caffeine’s Mechanisms of Action and Its Cosmetic Use
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2012) 26 (1): 8–14.
Published Online: 11 October 2012
...A. Herman; A.P. Herman Caffeine is being increasingly used in cosmetics due to its high biological activity and ability to penetrate the skin barrier. This alkaloid is frequently used as a hydrophilic model substance in human and animal skin penetration as well as different synthetic membrane using...
Journal Articles
Storage Conditions of Skin Affect Tissue Structure and Subsequent in vitro Percutaneous Penetration
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2011) 24 (2): 93–102.
Published Online: 23 December 2010
... study applies imaging techniques (multiphoton excitation fluorescence microscopy) and in vitro percutaneous penetration of caffeine under four different storage conditions using skin samples from the same donors: fresh skin, skin kept at –20°C for 3 weeks (with or without the use of polyethylene glycol...
Journal Articles
Development of an in vitro Modified Skin Absorption Test for the Investigation of the Follicular Penetration Pathway of Caffeine
Available to PurchaseS. Trauer, J. Lademann, F. Knorr, H. Richter, M. Liebsch, C. Rozycki, G. Balizs, R. Büttemeyer, M. Linscheid, A. Patzelt
Journal:
Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2010) 23 (6): 320–327.
Published Online: 26 June 2010
...S. Trauer; J. Lademann; F. Knorr; H. Richter; M. Liebsch; C. Rozycki; G. Balizs; R. Büttemeyer; M. Linscheid; A. Patzelt The Organization for Economic Cooperation and Development (OECD) recommends caffeine as a reference substance for in vitro skin absorption tests using Franz diffusion cells (FDC...
Journal Articles
Importance of Blood Flow to the Local Distribution of Drugs after Percutaneous Absorption in the Bipediculated Dorsal Flap of the Hairless Rat
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacology (1991) 4 (1): 1–8.
Published Online: 31 March 2009
... on both sides of the flap, one with normal blood flow and the other with a reproducible blood flow decrease (60%) obtained by ligation of one pedicle. 14 C-labelled compounds, progesterone (lipophilic), caffeine (amphiphilic) and urea (hydrophilic) were applied in ethanolic solution during 4 h on the two...
Journal Articles
Effect of Occlusion on in vitro Percutaneous Absorption of Two Compounds with Different Physicochemical Properties
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacology (1992) 5 (2): 108–113.
Published Online: 31 March 2009
... whereas that of caffeine (amphiphilic compound) remained unchanged. This lack of penetration enhancement under occluded conditions has also been observed by other authors, especially concerning hydrophilic and slightly lipophilic molecules. Our results support the view that occlusion does not necessarily...
Journal Articles
Permeation and Skin Absorption: Reproducibility of Various Industrial Reconstructed Human Skin Models
Available to Purchase
Journal:
Skin Pharmacology and Physiology
Skin Pharmacology and Applied Skin Physiology (2002) 15 (Suppl. 1): 18–30.
Published Online: 17 November 2004
... obtained, must be verified. The reproducibility of 3 industrial models – EpiDerm ® , Episkin ® and SkinEthic ® – was tested regarding the permeation and skin absorption of 3 topically applied compounds (with a large range of physicochemical properties): lauric acid, caffeine and mannitol. For all...
Journal Articles
Improvement of the Experimental Setup to Assess Cutaneous Bioavailability on Human Skin Models: Dynamic Protocol
Available to PurchaseF. Dreher, C. Patouillet, F. Fouchard, M. Zanini, A. Messager, R. Roguet, M. Cottin, J. Leclaire, F. Benech-Kieffer
Journal:
Skin Pharmacology and Physiology
Skin Pharmacology and Applied Skin Physiology (2002) 15 (Suppl. 1): 31–39.
Published Online: 17 November 2004
.... Leclaire F. Benech-Kieffer L Oréal Research, Aulnay-sous-Bois, France Key Words Human skin model W EpiDerm® W Episkin® W Percutaneous absorption W Dynamic diffusion cell W Benzoic acid W Caffeine W Mannitol Abstract Human skin models, such as EpiDerm® and Episkin®, are not easily mounted into static...
Journal Articles
Bioadhesive Transdermal Film Containing Caffeine
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Journal:
Skin Pharmacology and Physiology
Skin Pharmacology and Applied Skin Physiology (2004) 17 (3): 119–123.
Published Online: 23 April 2004
...S. Nicoli; V. Amoretti; P. Colombo; P. Santi The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were...