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Keywords: Caffeine
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Journal Articles
Skin Pharmacol Physiol (2022) 35 (4): 235–246.
Published Online: 16 February 2022
.... An experimental lateral MD setup was used to determine the influence of percutaneous skin penetration characteristics of an active ingredient with different lipophilic and hydrophilic characteristics. Therefore, hydrophilic caffeine and lipophilic LIP1, which have an identical molecular weight but different...
Journal Articles
Skin Pharmacol Physiol (2021) 34 (4): 203–213.
Published Online: 21 May 2021
... penetration studies. In study B, the lipophilic differences of the active ingredients and its influences on the penetration was tested using hydrophilic caffeine and lipophilic LIP1 as model compounds, which have an identical molecular weight with different lipophilic characteristics. It is assumed...
Journal Articles
Skin Pharmacol Physiol (2021) 33 (6): 309–316.
Published Online: 16 December 2020
...-stimulating agents. Materials and Methods: Using the hanging drop method, DPCs self-organized into spheroid shape, mirroring the three-dimensional (3D) structure of the DP in vivo. DP analogs were treated with established substances against AGA (minoxidil and caffeine) compared to HIF-1α-stimulating agents...
Journal Articles
Skin Pharmacol Physiol (2020) 33 (3): 153–169.
Published Online: 29 June 2020
...Jörn Michael Völker; Nadine Koch; Maike Becker; Adolf Klenk Caffeine, particularly after ingestion, is well known to exert various pharmacological effects. A growing body of evidence implicates the ingestion of caffeine with beneficial effects on several diseases. The easy penetration of caffeine...
Journal Articles
Journal Articles
Journal Articles
Skin Pharmacol Physiol (2016) 29 (1): 31–40.
Published Online: 26 November 2015
... time, a significant (p = 0.002) difference was found among all groups, but comparisons with fresh skin were not significant. Does glycerol have a cryoprotective effect? The steady-state flux and lag time of DEP and caffeine were measured through human skin stored at -85°C for up to 12 months...
Journal Articles
Skin Pharmacol Physiol (2012) 26 (1): 8–14.
Published Online: 11 October 2012
...A. Herman; A.P. Herman Caffeine is being increasingly used in cosmetics due to its high biological activity and ability to penetrate the skin barrier. This alkaloid is frequently used as a hydrophilic model substance in human and animal skin penetration as well as different synthetic membrane using...
Journal Articles
Skin Pharmacol Physiol (2011) 24 (2): 93–102.
Published Online: 23 December 2010
... study applies imaging techniques (multiphoton excitation fluorescence microscopy) and in vitro percutaneous penetration of caffeine under four different storage conditions using skin samples from the same donors: fresh skin, skin kept at –20°C for 3 weeks (with or without the use of polyethylene glycol...
Journal Articles
Journal Articles
Journal Articles
Skin Pharmacology (1992) 5 (2): 108–113.
Published Online: 31 March 2009
... whereas that of caffeine (amphiphilic compound) remained unchanged. This lack of penetration enhancement under occluded conditions has also been observed by other authors, especially concerning hydrophilic and slightly lipophilic molecules. Our results support the view that occlusion does not necessarily...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2002) 15 (Suppl. 1): 18–30.
Published Online: 17 November 2004
... obtained, must be verified. The reproducibility of 3 industrial models – EpiDerm ® , Episkin ® and SkinEthic ® – was tested regarding the permeation and skin absorption of 3 topically applied compounds (with a large range of physicochemical properties): lauric acid, caffeine and mannitol. For all...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2002) 15 (Suppl. 1): 31–39.
Published Online: 17 November 2004
... skin model EpiDerm ® Episkin ® Percutaneous absorption Dynamic diffusion cell Benzoic acid Caffeine Mannitol Skin Pharmacology andApplied Skin Physiology Skin Pharmacol Appl Skin Physiol 2002;15(suppl 1):31 39 DOI: 10.1159/000066683 Improvement of the Experimental Setup to Assess Cutaneous...
Journal Articles
Skin Pharmacology and Applied Skin Physiology (2004) 17 (3): 119–123.
Published Online: 23 April 2004
...S. Nicoli; V. Amoretti; P. Colombo; P. Santi The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were...