... to sebaceous carcinoma, however, the relevant molecular mechanisms have not been fully clarified. Objectives: The induction of autophagy and apoptosis in human sebocytes in response to biologically relevant fatty acids was investigated. Methods: Free fatty acids (arachidonic acid, linoleic acid, palmitic acid...

...Georgios Kokolakis; Robert Sabat; Sabine Krüger-Krasagakis; Jürgen Eberle Introduction: Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that may paradoxically induce either apoptosis or cell survival. It mediates its activity through binding of TNF-receptor (TNFR) 1 or 2. TNFR1...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chitosan Cytotoxicity HaCaT keratinocytes Cytokine release Caspases 3/7 Caspase 8 Caspase 9 Apoptosis Original Paper Skin Pharmacol Physiol 2010;23:164 170 DOI...

...J. Yun; H. Park; J.-H. Ko; W. Lee; K. Kim; T. Kim; J. Shin; K. Kim; K. Kim; J.-H. Song; Y.-H. Noh; H. Bang; I. Lim Backgrounds/Aims: Cell proliferation and apoptosis are responsible for maintaining normal tissue homeostasis, and K + currents play important roles in regulating the physiological...

... M ), As 2 O 3 inhibited cell growth in NHK and HaCaT cells, but not in A431 cells. As 2 O 3 significantly induced NHK and HaCaT apoptosis through the activation of caspase-3, as well as cell cycle arrest at the G2–M phase. Conclusion: Our data suggest that different pathways are involved in As 2 O 3...

..., MMP-1 and elastin in cultured keratinocytes and fibroblasts. Ceramide inhibited keratinocyte cell viability by apoptosis and stimulated expression of elastin, MMP-1 and TGF-β, suggesting improved epidermal functioning by a TGF-β mechanism. Conversely, ceramide stimulated fibroblast cell growth...

... to explain. Methods: We analyzed the effect of all- trans retinoic acid (all- trans RA), 13- cis retinoic acid (13- cis RA), ergocalciferol and cholecalciferol in keratinocyte cultures established from adult donors, on the cell proliferation by means of [ 3 H]thymidine incorporation and apoptosis after...

... activity with early induction of the catagen. Thus, we investigated the influence of T and 5α-DHT on proliferation, cell death and bcl-2/bax expression in cultured dermal papilla cells (DPC) from nonbalding scalp regions of healthy volunteers. T and 5α-DHT induced apoptosis in DPC in a dose-dependent...

... fivefold more strongly than chlorin e6 after 24 h. HaCaT cells are susceptible to PDT with both dyes. The phototoxicity measured by ATP bioluminescence is caused by necrosis and apoptosis depending on the photosensitizer used and the treatment modality. Chlorin e6 shows higher toxic potential because...

... or TGF-β 2 to hair epithelial cell cultures dose-dependently decreased cell growth and induced apoptosis; however, addition of procyanidin B-2 to the culture neutralized the growth-inhibiting effects of both TGF-β 1 and TGF-β 2 and protected the cells from apoptosis. The same effects were observed...

...Q.-X. Zhu; T. Shen; D.-Y. Tu; R. Ding; Z.-Z. Liang; X.-J. Zhang The objective of this study was to assess the protective effects of Ginkgo biloba leaf extracts (EGb) on trichloroethylene (TCE)-induced cytotoxicity and apoptosis in normal human epidermal keratinocytes (NHEK). Cytotoxicity...

...C. Drewniok; M. Schön; M.P. Schön Basal cell adhesion molecule (B-CAM) is strongly upregulated in epithelial skin cancer cells in vivo and in vitro. We have tested here whether B-CAM is (1) inversely associated with or (2) functionally involved in apoptosis. Towards this end, B-CAM expression...

... examined the immunohistochemical expression of apoptosis-regulated protein in the involved psoriatic skin following topical anthralin therapy. Biopsy specimens were obtained from back skins treated with topical anthralin or white petrolatum (control) in 4 patients with psoriasis vulgaris...

...R. Weller; T. Billiar; Y. Vodovotz Ultraviolet radiation (UV) induces apoptosis in keratinocytes by both p53- and death receptor-dependent pathways. It also generates free radicals in keratinocytes, including the synthesis of nitric oxide (NO) by constitutive and inducible NO synthases (NOS...

...Dagmar Kulms; Thomas Schwarz Ultraviolet radiation (UV) induces a variety of biological effects which include the induction of programmed cell death. UV-induced apoptosis seems to represent a controlled scavenging mechanism which protects cells from malignant transformation in human skin. To exert...

... the transcription of prosurvival genes. In the present study, investigation of normal human melanocytes revealed induction of apoptosis after TNF-α treatment (100 U/ml) in only 3 out of 11 cultures analyzed, whereas 8 cultures remained largely resistant. In sensitive cultures, NF-ĸB binding activity was found...

..., Cleveland, Ohio, USA Key Words Transglutaminase W Cornified envelope W Keratinocyte W Differentiation W Cross-linking W Isopeptide bond W Apoptosis Abstract Human involucrin (hINV) is assembled into cornified structures via formation of transglutaminase (TG)-dependent interprotein glutamyl)lysine bonds...

... suggest a delayed progression through S-phase of DHP-treated HaCaT cells. It has been proven that necrotic and apoptotic cell death were also causes for the DHP-induced decrease in proliferation. Moreover, in HaCaT cultures treated with the highest DHP concentration, apoptosis occurred to a much greater...

..., instructions or products referred to in the content or advertisements. Apoptosis Cytotoxicity Glutathione Proinflammatory cytokines Psoriasis Original Research Article Skin Pharmacol Appl Skin Physiol 1999;12:64 78 Received: Aug. 4, 1998 Accepted: Oct. 29, 1998 Ethanol-Modulated Cytokine...