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Keywords: Anti-drug antibodies
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Journal Articles

Evaluation of the Immunogenicity of the Synthetic α-Melanocyte-Stimulating Hormone (α-MSH) Analogue Afamelanotide ([Nle4-D-Phe7]-α-MSH, Scenesse®) in Erythropoietic Protoporphyria Patients by ELISA Detecting Both Anti-Afamelanotide and Anti-α-MSH Antibodies

Subject Area:
Dermatology , Pharmacology
Stephan Lengweiler, Saskia Kreim, Jasmin Barman-Aksözen, Marcus Maurer, Elisabeth I. Minder
Journal: Skin Pharmacology and Physiology
Skin Pharmacol Physiol (2015) 28 (2): 103–113.
https://doi.org/10.1159/000362174
Published Online: 13 November 2014
... prolonged time, may induce anti-drug antibodies (ADA). Here, we describe a new ELISA method developed to monitor the occurrence of ADA against afamelanotide as well as against α-MSH. Covalent binding instead of absorption of antigen onto the microtitre wells prevented antigen leakage and enabled extensive...
View article titled, Evaluation of the Immunogenicity of the Synthetic α-Melanocyte-Stimulating Hormone (α-MSH) Analogue Afamelanotide ([Nle4-D-Phe7]-α-MSH, Scenesse®) in Erythropoietic Protoporphyria Patients by ELISA Detecting Both Anti-Afamelanotide and Anti-α-MSH Antibodies
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