..., but is a very potent inhibitor of endogenous vitamin A metabolism in human epidermal cells. To further extend this observation, we studied the effect of 12 different retinoids on the metabolism of [ 3 H]retinol ([ 3 H]ROH) in HeLa cells, previously shown to produce constant levels of 3,4-didehydroretinol (ddROH...

...Hans Törmä; Eva Stenström; Eva Andersson; Anders Vahlquist For unknown reasons, the epidermal concentrations of retinol and its metabolite 3,4-didehydroretinol become characteristically changed during treatment with certain synthetic retinoids. In the present study we investigated [ 3 H]retinol...

...Hans Törmä; Anders Vahlquist The concentration of 3,4-didehydroretinol, an epidermal metabolite of retinol, is changed both in association with keratinizing disorders and during treatment with certain synthetic retinoids. To delineate further the factors regulation biosynthesis of 3,4-didehy...