Introduction: Seborrhea or oily skin has been one of the most common complaints affecting both men and women physically and psychologically. Chitosan is a biopolymer obtained from the alkaline deacetylation of chitin. Due to its positively charged nature, chitosan can effectively bind to lipids. Therefore, chitosan nanoparticle (CN) formulation may benefit in the reduction of skin sebum. Objective: The aim of this study was to evaluate the efficacy and safety of CN formulation in the reduction of skin sebum. Method: The study was a randomized, double-blinded, placebo-controlled trial in 24 participants aged 18–40 years with clinical seborrhea. Participants were randomly assigned to apply the CN and gum (CN-G) or placebo (gum alone) twice daily for 4 weeks. Sebum level, corneometry, transepidermal water loss (TEWL), and clinical seborrhea grading were evaluated at baseline and week 2 and 4. Results: In the T-zone, sebum levels in the CN-G group were significantly lower than the placebo group at week 4 (p = 0.043), while for the U-zone, sebum levels were not different between groups. There were no statistical differences in corneometry and TEWL at any visit. Although the clinical seborrhea grading in CN-G was lower, it was not significantly different from the placebo. A few cases reported mild and self-limiting scaling and acneiform eruption. Conclusion: The CN-G gel could significantly reduce sebum levels on seborrhea patients with acceptable safety profiles.

1.
Segot-Chicq
E
,
Compan-Zaouati
D
,
Wolkenstein
P
,
Consoli
S
,
Rodary
C
,
Delvigne
V
,
Development and validation of a questionnaire to evaluate how a cosmetic product for oily skin is able to improve well-being in women
.
J Eur Acad Dermatol Venereol
.
2007
;
21
(
9
):
1181
6
.
2.
Arbuckle
R
,
Atkinson
MJ
,
Clark
M
,
Abetz
L
,
Lohs
J
,
Kuhagen
I
,
Patient experiences with oily skin: the qualitative development of content for two new patient reported outcome questionnaires
.
Health Qual Life Outcomes
.
2008
;
6
:
80
. .
3.
Ro
BI
,
Dawson
TL
.
The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff
.
J Investig Dermatol Symp Proc
.
2005
;
10
(
3
):
194
7
. .
4.
Leyden
JJ
.
New understandings of the pathogenesis of acne
.
J Am Acad Dermatol
.
1995
;
32
(
5, Part 3
):
S15
25
.
5.
Endly
DC
,
Miller
RA
.
Oily skin: a review of treatment options
.
J Clin Aesthet Dermatol
.
2017
;
10
(
8
):
49
55
.
6.
Nikkari
T
.
Comparative chemistry of sebum
.
J Invest Dermatol
.
1974
;
62
(
3
):
257
67
. .
7.
Camera
E
,
Ludovici
M
,
Galante
M
,
Sinagra
JL
,
Picardo
M
.
Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry
.
J Lipid Res
.
2010
;
51
(
11
):
3377
88
. .
8.
Kim
B
,
Choi
J
,
Park
K
,
Youn
S
.
Sebum, acne, skin elasticity, and gender difference - which is the major influencing factor for facial pores?
Skin Res Technol
.
2013
;
19
(
1
):
e45
53
. .
9.
Sugiyama-Nakagiri
Y
,
Sugata
K
,
Hachiya
A
,
Osanai
O
,
Ohuchi
A
,
Kitahara
T
.
Ethnic differences in the structural properties of facial skin
.
J Dermatol Sci
.
2009
;
53
(
2
):
135
9
. .
10.
Plewig
GKA
.
Acne and rosacea
. 3rd ed.
Berlin
:
Springer
;
2000
.
11.
Schaller
MPG
.
Structure and function of eccrine, apocrine, and sebaceous glands
. In:
Bolognia
JLJJ
,
Schaffer
JV
, editors.
Dermatology.
3rd ed.
Philadelphia
:
Elsevier
;
2012
. p.
539
44
.
12.
Endly
DC
,
Miller
RA
.
Oily skin: a review of treatment options
.
J Clin Aesthet Dermatol
.
2017
;
10
(
8
):
49
55
.
13.
Verlee
A
,
Mincke
S
,
Stevens
CV
.
Recent developments in antibacterial and antifungal chitosan and its derivatives
.
Carbohydr Polym
.
2017
;
164
:
268
83
. .
14.
Muxika
A
,
Etxabide
A
,
Uranga
J
,
Guerrero
P
,
de la Caba
K
.
Chitosan as a bioactive polymer: processing, properties and applications
.
Int J Biol Macromol
.
2017
;
105
(
Pt 2
):
1358
68
. .
15.
Cosmetics
JH
.
Applications of adaptive and functional polymers
. In:
Hu
J
, editor.
Adaptive and functional polymers, textiles and their applications
.
London
:
Imperial College Press
;
2011
. p.
258
73
.
16.
Malik
A
,
Gupta
M
,
Mani
R
,
Gogoi
H
,
Bhatnagar
R
.
Trimethyl chitosan nanoparticles encapsulated protective antigen protects the mice against anthrax
.
Front Immunol
.
2018
;
9
:
562
. .
17.
Nauss
JL
,
Thompson
JL
,
Nagyvary
J
.
The binding of micellar lipids to chitosan
.
Lipids
.
1983
;
18
(
10
):
714
9
. .
18.
Muzzarelli
RAA
,
Frega
N
,
Miliani
M
,
Muzzarelli
C
,
Cartolari
M
.
Interactions of chitin, chitosan, N-lauryl chitosan and N-dimethylaminopropyl chitosan with olive oil
.
Carbohydr Polym
.
2000
;
43
(
3
):
263
8
. .
19.
Abd-Allah
H
,
Abdel-Aziz
RTA
,
Nasr
M
.
Chitosan nanoparticles making their way to clinical practice: a feasibility study on their topical use for acne treatment
.
Int J Biol Macromol
.
2020
;
156
:
262
70
. .
20.
Sezer
AD
,
Cevher
E
.
Topical drug delivery using chitosan nano- and microparticles
.
Expert Opin Drug Deliv
.
2012
;
9
(
9
):
1129
46
. .
21.
Elmowafy
E
,
El-Gogary
RI
,
Ragai
MH
,
Nasr
M
.
Novel antipsoriatic fluidized spanlastic nanovesicles: in vitro physicochemical characterization, ex vivo cutaneous retention and exploratory clinical therapeutic efficacy
.
Int J Pharm
.
2019
;
568
:
118556
. .
22.
Tangkijngamvong
N
,
Phaiyarin
P
,
Wanichwecharungruang
S
,
Kumtornrut
C
.
The anti-sebum property of chitosan particles
.
J Cosmet Dermatol
.
2020
;
19
(
8
):
2135
40
. .
23.
Baumann
LS
,
Penfield
RD
,
Clarke
JL
,
Duque
DK
.
A validated questionnaire for quantifying skin oiliness
.
J Chem Dermatol Sci Appl
.
2014
;
4
(
2
):
78
84
. .
24.
Rinaudo
M
.
Chitin and chitosan: properties and applications
.
Prog Polym Sci
.
2006
;
31
(
7
):
603
32
. .
25.
Lademann
J
,
Richter
H
,
Teichmann
A
,
Otberg
N
,
Blume-Peytavi
U
,
Luengo
J
,
Nanoparticles – an efficient carrier for drug delivery into the hair follicles
.
Eur J Pharm Biopharm
.
2007
;
66
(
2
):
159
64
. .
26.
Pisetpackdeekul
P
,
Supmuang
P
,
Pan-In
P
,
Banlunara
W
,
Limcharoen
B
,
Kokpol
C
,
Proretinal nanoparticles: stability, release, efficacy, and irritation
.
Int J Nanomedicine
.
2016
;
11
:
3277
86
. .
27.
Rogiers
V
.
EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences
.
Skin Pharmacol Appl Skin Physiol
.
2001 Mar–Apr
;
14
(
2
):
117
28
. .
28.
Fujii
M
,
Shimizu
T
,
Nakamura
T
,
Endo
F
,
Kohno
S
,
Nabe
T
.
Inhibitory effect of chitosan-containing lotion on scratching response of hairless mice with atopic dermatitis-like dry skin
.
Biol Pharm Bull
.
2011
;
34
(
12
):
1890
4
. .
29.
Jimtaisong
A
,
Saewan
N
.
Utilization of carboxymethyl chitosan in cosmetics
.
Int J Cosmet Sci
.
2014
;
36
(
1
):
12
21
. .
30.
Bidgoli
H
,
Zamani
A
,
Taherzadeh
MJ
.
Effect of carboxymethylation conditions on the water-binding capacity of chitosan-based superabsorbents
.
Carbohydr Res
.
2010
;
345
(
18
):
2683
9
. .
31.
Sun
L-P
,
Du
Y-M
,
Shi
X-W
,
Chen
X
,
Yang
J-H
,
Xu
Y-M
.
A new approach to chemically modified carboxymethyl chitosan and study of its moisture-absorption and moisture-retention abilities
.
J Appl Polym Sci
.
2006
;
102
(
2
):
1303
9
. .
32.
Kumirska
J
,
Weinhold
MX
,
Thöming
J
,
Stepnowski
P
.
Biomedical activity of chitin/chitosan based materials-influence of physicochemical properties apart from molecular weight and degree of N-acetylation
.
Polymers
.
2011
;
3
(
4
):
1875
901
. .
33.
Chen
L
,
Du
Y
,
Zeng
X
.
Relationships between the molecular structure and moisture-absorption and moisture-retention abilities of carboxymethyl chitosan: II. Effect of degree of deacetylation and carboxymethylation
.
Carbohydrate Research
.
2003
;
338
(
4
):
333
40
.
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