Abstract
Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in Capsicum fruits. Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. Key Messages: Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.
References
1.
Aresti
JS
, El
SA
. Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response
. ISO
. 2019
;236
(5
):1597
.2.
de Aguiar
AC
, Sales
LP
, Coutinho
JP
, Barbero
GF
, Godoy
HT
, Martínez
J
. Supercritical carbon dioxide extraction of Capsicum peppers: global yield and capsaicinoid content
. J Supercrit Fluids
. 2013
;81
:210
–6
. .3.
Rhim
J-W
, Hong
S-I
. Effect of water activity and temperature on the color change of red pepper (Capsicum annuum L.) powder
. Food Sci Biotechnol
. 2011
;20
(1
):215
–22
. .4.
O’Neill
J
, Brock
C
, Olesen
AE
, Andresen
T
, Nilsson
M
, Dickenson
AH
. Unravelling the mystery of capsaicin: a tool to understand and treat pain
. Pharmacol Rev
. 2012
;64
(4
):939
–71
. .5.
Chapa-Oliver
A
, Mejía-Teniente
L
. Capsaicin: from plants to a cancer-suppressing agent
. Molecules
. 2016
;21
(8
):931
. .6.
7.
Antonio
A
, Wiedemann
LSM
, Veiga
VF
. The genus Capsicum: a phytochemical review of bioactive secondary metabolites
. RSC Adv
. 2018
;8
(45
):25767
–84
.8.
Nelson
EK
. The constitution of capsaicin, the pungent principle of Capsicum
. J Am Chem Soc
. 1919
;41
(7
):1115
–21
. .9.
Suresh
D
, Srinivasan
K
. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats
. Indian J Med Res
. 2010
;131
(5
):682
.10.
Baenas
N
, Belović
M
, Ilic
N
, Moreno
DA
, García-Viguera
C
. Industrial use of pepper (Capsicum annum L.) derived products: technological benefits and biological advantages
. Food Chem
. 2019
;274
:872
–85
. .11.
Antonio
A
, Wiedemann
LSM
, Veiga
VF
. The genus Capsicum: a phytochemical review of bioactive secondary metabolites
. RSC Adv
. 2018
;8
(45
):25767
–84
.12.
Sganzerla
M
, Coutinho
JP
, de Melo
AMT
, Godoy
HT
. Fast method for capsaicinoids analysis from Capsicum chinense fruits
. Food Res Int
. 2014
;64
:718
–25
. .13.
Sun
F
, Xiong
S
, Zhu
Z
. Dietary capsaicin protects cardiometabolic organs from dysfunction
. Nutrients
. 2016
;8
(5
):174
. .14.
Basith
S
, Cui
M
, Hong
S
, Choi
S
. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases
. Molecules
. 2016
;21
(8
):966
. .15.
Myszka
K
, Leja
K
, Majcher
M
. A current opinion on the antimicrobial importance of popular pepper essential oil and its application in food industry
. J Essent Oil Res
. 2019
;31
(1
):1
–18
. .16.
Yang
F
, Zheng
J
. Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
. Protein Cell
. 2017
;8
(3
):169
–77
. .17.
Fernando
RRS
, Swaminathan
V
. Effect of a nutrition education program on nutritional knowledge and dietary behaviour of children in the age group of 7 to 9 years
. Int J Appl Res
. 2015
;1
(12
):445
–9
.18.
Fattori
V
, Hohmann
MS
, Rossaneis
AC
, Pinho-Ribeiro
FA
, Verri
WA
. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
. Molecules
. 2016
;21
(7
):844
. .19.
Randhawa
PK
, Jaggi
AS
. Investigating the involvement of TRPV 1 ion channels in remote hind limb preconditioning-induced cardioprotection in rats
. Naunyn Schmiedebergs Arch Pharmacol
. 2017
;390
(2
):117
–26
.20.
Gharat
L
, Szallasi
A
. Medicinal chemistry of the vanilloid (capsaicin) TRPV1 receptor: current knowledge and future perspectives
. Drug Dev Res
. 2007
;68
(8
):477
–97
. .21.
McCarty
MF
, DiNicolantonio
JJ
, O’Keefe
JH
. Capsaicin may have important potential for promoting vascular and metabolic health
. Open Heart
. 2015
;2
(1
):e000262
. .22.
McCarty
MF
, DiNicolantonio
JJ
, O’Keefe
JH
. Capsaicin may have important potential for promoting vascular and metabolic health
. Open Heart
. 2015
;2
(1
):e000262
. .23.
Fattori
V
, Hohmann
MS
, Rossaneis
AC
, Pinho-Ribeiro
FA
, Verri
WA
. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
. Molecules
. 2016
;21
(7
):844
. .24.
Vangeel
L
, Voets
T
. Transient receptor potential channels and calcium signaling
. Cold Spring Harb Perspect Biol
. 2019
;11
(6
):a035048
. .25.
Mulier
M
, Vriens
J
, Voets
T
. TRP channel pores and local calcium signals
. Cell Calcium
. 2017
;66
:19
–24
. .26.
Fattori
V
, Hohmann
MS
, Rossaneis
AC
, Pinho-Ribeiro
FA
, Verri
WA
. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
. Molecules
. 2016
;21
(7
):844
. .27.
Vangeel
L
, Voets
T
. Transient receptor potential channels and calcium signaling
. Cold Spring Harb Perspect Biol
. 2019
;11
(6
):a035048
. .28.
Wood
BM
. A study of the spatiotemporal regulation of calmodulin kinase superfamily members in cardiac myocytes
. Davis
: University of California
; 2017
.29.
Vangeel
L
, Voets
T
. Transient receptor potential channels and calcium signaling
. Cold Spring Harb Perspect Biol
. 2019
;11
(6
):a035048
. .30.
Yoshie
K
, Rajendran
PS
, Massoud
L
, Kwon
O
, Tadimeti
V
, Salavatian
S
, et al. Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress
. Am J Physiol Heart Circ Physiol
. 2018
;314
(5
):H954
–66
. .31.
Christie
S
, Wittert
GA
, Li
H
, Page
AJ
. Involvement of TRPV1 channels in energy homeostasis
. Front Endocrinol
. 2018
;9
:420
. .32.
Zhang
W-C
, Zheng
XJ
, Du
LJ
, Sun
JY
, Shen
ZX
, Shi
C
, et al. High salt primes a specific activation state of macrophages, M(Na)
. Cell Res
. 2015
;25
(8
):893
–110
.33.
Cao
YQ
, Mantyh
PW
, Carlson
EJ
, Gillespie
AM
, Epstein
CJ
, Basbaum
AI
. Primary afferent tachykinins are required to experience moderate to intense pain
. Nature
. 1998
;392
(6674
):390
–4
. .34.
McCoy
ES
, Taylor-Blake
B
, Street
SE
, Pribisko
AL
, Zheng
J
, Zylka
MJ
. Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold
. Neuron
. 2013
;78
(1
):138
–51
. .35.
Salmon
AM
, Damaj
I
, Sekine
S
, Picciotto
MR
, Marubio
L
, Changeux
JP
. Modulation of morphine analgesia in alphaCGRP mutant mice
. Neuroreport
. 1999
;10
(4
):849
–54
. .36.
Zhang
L
, Hoff
AO
, Wimalawansa
SJ
, Cote
GJ
, Gagel
RF
, Westlund
KN
. Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity
. Pain
. 2001
;89
(2–3
):265
–73
. .37.
Gustavsson
N
, Wu
B
, Han
W
. Calcium sensing in exocytosis
. Adv Exp Med Biol
. 2012
;740
:731
–57
. .38.
Zhao
B
, Wang
HB
, Lu
YJ
, Hu
JW
, Bao
L
, Zhang
X
. Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles
. Cell Res
. 2011
;21
(5
):741
–53
. .39.
Malin
SA
, Davis
BM
, Koerber
HR
, Reynolds
IJ
, Albers
KM
, Molliver
DC
. Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2
. Pain
. 2008
;138
(3
):484
–96
. .40.
Moriyama
T
, Iida
T
, Kobayashi
K
, Higashi
T
, Fukuoka
T
, Tsumura
H
, et al. Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity
. J Neurosci
. 2003
;23
(14
):6058
–62
. .41.
Tominaga
M
, Wada
M
, Masu
M
. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
. Proc Natl Acad Sci U S A
. 2001
;98
(12
):6951
–6
. .42.
Zheng
W
, Wen
H
. Heat activation mechanism of TRPV1: new insights from molecular dynamics simulation
. Temperature
. 2019
;6
(2
):120
–31
. .43.
Winkler
M
, Moraux
T
, Khairy
HA
, Scott
RH
, Slawin
AM
, O’Hagan
D
. Synthesis and vanilloid receptor (TRPV1) activity of the enantiomers of α-fluorinated capsaicin
. ChemBioChem
. 2009
;10
(5
):823
–8
.44.
Vandewauw
I
, De Clercq
K
, Mulier
M
, Held
K
, Pinto
S
, Van Ranst
N
, et al. A TRP channel trio mediates acute noxious heat sensing
. Nature
. 2018
;555
(7698
):662
. .45.
Gharat
L
, Szallasi
A
. Medicinal chemistry of the vanilloid (capsaicin) TRPV1 receptor: current knowledge and future perspectives
. Drug Dev Res
. 2007
;68
(8
):477
–97
. .46.
Christie
S
, Wittert
GA
, Li
H
, Page
AJ
. Involvement of TRPV1 channels in energy homeostasis
. Front Endocrinol
. 2018
;9
:420
. .47.
Cho
SC
, Lee
H
, Choi
BY
. An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
. Food Sci Biotechnol
. 2017
;26
(1
):1
–13
. .48.
McArthur
JR
, et al. Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels
. Br J Pharmacol
. 2019
. .49.
Fattori
V
, Hohmann
MS
, Rossaneis
AC
, Pinho-Ribeiro
FA
, Verri
WA
. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
. Molecules
. 2016
;21
(7
):844
. .50.
Rezaeian
AH
, Isokane
T
, Nishibori
M
, Chiba
M
, Hiraiwa
N
, Yoshizawa
M
, et al. αCGRP and βCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites
. Brain Dev
. 2009
;31
(9
):682
–93
. .51.
Khalil
M
, Alliger
K
, Weidinger
C
, Yerinde
C
, Wirtz
S
, Becker
C
, et al. Functional role of transient receptor potential channels in immune cells and epithelia
. Front Immunol
. 2018
;9
:174
. .52.
Janssens
PL
, Hursel
R
, Martens
EA
, Westerterp-Plantenga
MS
. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance
. PLoS One
. 2013
;8
(7
):e67786
. .53.
Jolayemi
ATE
. Capsaicin: aromatic basis and mechanism of action: an example of positive inhibition
. Aromat Med Plants
. 2017
:239
.54.
Kang
JH
, Tsuyoshi
G
, Le Ngoc
H
, Kim
HM
, Tu
TH
, Noh
HJ
, et al. Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice
. J Med Food
. 2011
;14
(3
):310
–5
. .55.
McCarty
MF
, DiNicolantonio
JJ
, O’Keefe
JH
. Capsaicin may have important potential for promoting vascular and metabolic health
. Open Heart
. 2015
;2
(1
):e000262
. .56.
Georgescu
S-R
, Sârbu
M-I
, Matei
C
, Ilie
M
, Caruntu
C
, Constantin
C
, et al. Capsaicin: friend or foe in skin cancer and other related malignancies?
Nutrients
. 2017
;9
(12
):1365
. .57.
McCarty
MF
, DiNicolantonio
JJ
, O’Keefe
JH
. Capsaicin may have important potential for promoting vascular and metabolic health
. Open Heart
. 2015
;2
(1
):e000262
. .58.
Basith
S
, Cui
M
, Hong
S
, Choi
S
. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases
. Molecules
. 2016
;21
(8
):966
. .59.
Lotti
T
, Hautmann
G
, Panconesi
E
. Neuropeptides in skin
. J Am Acad Dermatol
. 1995
;33
(3
):482
–96
. .60.
Li
H
, Yu
B
, Li
J
, Su
L
, Yan
M
, Zhu
Z
, et al. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer
. Oncotarget
. 2014
;5
(8
):2318
. .61.
Grigore
O
, Mihailescu
AI
, Solomon
I
, Boda
D
, Caruntu
C
. Role of stress in modulation of skin neurogenic inflammation
. Exp Ther Med
. 2019
;17
(2
):997
–1003
. .62.
Căruntu
C
, Boda
D
, Musat
S
, Căruntu
A
, Mandache
E
. Stress-induced mast cell activation in glabrous and hairy skin
. Mediat Inflamm
. 2014
;2014
:105950
.63.
Ghiasi
Z
, Esmaeli
F
, Aghajani
M
, Ghazi-Khansari
M
, Faramarzi
MA
, Amani
A
. Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: an in vivo study
. Int J Pharm
. 2019
;559
:341
–7
. .64.
Yaksh
TL
, Di Nardo
A
. Complexity of systems and actions underlying neurogenic inflammation
. Semin Immunol
. 2018 May
;40
(3
):225
–8
.65.
Desai
PR
, Marepally
S
, Patel
AR
, Voshavar
C
, Chaudhuri
A
, Singh
M
. Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo
. J Control Release
. 2013
;170
(1
):51
–63
. .66.
Gupta
D
. Atopic dermatitis
. Med Clin North Am
. 2015
;99
(6
):1269
. .67.
Jin
H
, He
R
, Oyoshi
M
, Geha
RS
. Animal models of atopic dermatitis
. J Invest Dermatol
. 2009
;129
(1
):31
. .68.
Back
SK
, Jeong
K-Y
, Li
C
, Lee
J
, Lee
S-B
, Na
HS
. Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis
. J Dermatol Sci
. 2012
;67
(2
):111
. .69.
Sclafani
A.
, Ackroff
K.
Capsaicin-induced visceral deafferentation does not attenuate flavor conditioning by intragastric fat infusions in mice
. Physiol Behav
. 2019
;208
:112586
.70.
Kim
M
, Kwon
Y
, Jung
H
S, Kim
Y
, Jeoung
D
. FcεRI-HDAC3-MCP1 Signaling Axis Promotes Passive Anaphylaxis Mediated by Cellular Interactions
. Int J Mol Sci
. 2019
;20
(19
):4964
.71.
Murakami
K
, Ito
M
, Htay
HH
, Tsubouchi
R
, Yoshino
M
. Antioxidant effect of capsaicinoids on the metal-catalyzed lipid peroxidation
. Biomed Res
. 2001
;22
(1
):15
. .72.
Oh
M
S, Hong
J
Y, Kim
M
N, Kwak
E
J, Kim
S
Y, Kim
E
G, et al. Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis.
Allergy Asthma Immunol Res
. 2019
;11
(5
):677
–690
.73.
Hiura
A
. Neuroanatomical effects of capsaicin on the primary afferent neurons
. Arch Histol Cytol
. 2000
;63
(3
):199
–215
. .74.
Margolis
D
, Mitra
N
, Wubbenhorst
B
, Nathanson
KL
. Filaggrin sequencing and bioinformatics tools
. Arch Dermatol Res
. 2020
;312
(2
):155
–8
.75.
Trzeciak
M
, Sakowicz-Burkiewicz
M
, Wesserling
M
, Gleń
J
, Dobaczewska
D
, Bandurski
T
, et al. Altered expression of genes encoding cornulin and repetin in atopic dermatitis.
Int Arch Allergy Immunol
. 2017
;172
(1
):11
–19
.76.
Sandilands
A
, Sutherland
C
, Irvine
AD
, McLean
WHI
. Filaggrin in the frontline: role in skin barrier function and disease
. J Cell Sci
. 2009
;122
(9
):1285
. .77.
Ishida-Yamamoto
A
, Igawa
S
. The biology and regulation of corneodesmosomes
. Cell Tissue Res
. 2014
;360
(3
):477
. .78.
Caubet
C
, Jonca
N
, Brattsand
M
, Guerrin
M
, Bernard
D
, Schmidt
R
, et al. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
. J Invest Dermatol
. 2004
;122
(5
):1235
. .79.
Sakabe
J-i.
, Yamamoto
M
, Hirakawa
S
, Motoyama
A
, Ohta
I
, Tatsuno
K
, et al. Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
. J Biol Chem
. 2013
;288
(24
):17179
. .80.
Epp
N
, Fürstenberger
G
, Müller
K
, de Juanes
S
, Leitges
M
, Hausser
I
, et al. 12R-lipoxygenase deficiency disrupts epidermal barrier function
. J Cell Biol
. 2007
;177
(1
):173
. .81.
Leyvraz
C
, Charles
R-P
, Rubera
I
, Guitard
M
, Rotman
S
, Breiden
B
, et al. The epidermal barrier function is dependent on the serine protease CAP1/Prss8
. J Cell Biol
. 2005
;170
(3
):487
. .82.
List
K
, Szabo
R
, Wertz
PW
, Segre
J
, Haudenschild
CC
, Kim
S-Y
, et al. Loss of proteolytically processed filaggrin caused by epidermal deletion of matriptase/MT-SP1
. J Cell Biol
. 2003
;163
(4
):901
. .83.
de Veer
SJ
, Furio
L
, Harris
JM
, Hovnanian
A
. Proteases: common culprits in human skin disorders
. Trends Mol Med
. 2014
;20
(3
):166
. .84.
Ovaere
P
, Lippens
S
, Vandenabeele
P
, Declercq
W
. The emerging roles of serine protease cascades in the epidermis
. Trends Biochem Sci
. 2009
;34
(9
):453
. .85.
WHO
. Global report on psoriasis
. Geneva, Switzerland
: WHO Press
; 2016
.86.
Menter
A
, Gottlieb
A
, Feldman
SR
, Van Voorhees
AS
, Leonardi
CL
, Gordon
KB
, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
. J Am Acad Dermatol
. 2008
;58
(5
):826
–50
. .87.
Moller
AH
, Erntoft
S
, Vinding
GR
, Jemec
GB
. A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ-5D-derived utility values
. Patient Relat Outcome Meas
. 2015
;6
:167
–77
.88.
Rachakonda
TD
, Schupp
CW
, Armstrong
AW
. Psoriasis prevalence among adults in the United States
. J Am Acad Dermatol
. 2014
;70
(3
):512
–6
. .89.
American Academy of Dermatology Work Group
; Menter
A
, Menter
A
, Korman
NJ
, Elmets
CA
, Feldman
SR
, Gelfand
JM
, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions
. J Am Acad Dermatol
. 2011
;65
(1
):137
–74
. .90.
Komiya
E
, Tominaga
M
, Kamata
Y
, Suga
Y
, Takamori
K
. Molecular and Cellular Mechanisms of Itch in Psoriasis
. Int J Mol Sci
. 2020
;21
(21
):8406
.91.
Szepietowski
JC
, Reich
A
. Itch in psoriasis management
. Curr Probl Dermatol
. 2016
;50
:102
–10
. .92.
Lebwohl
MG
, Kavanaugh
A
, Armstrong
AW
, Van Voorhees
AS
. US perspectives in the management of psoriasis and psoriatic arthritis: patient and physician results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) survey
. Am J Clin Dermatol
. 2016
;17
:87
–97
.93.
Shahwan
KT
, Kimball
AB
. Itch intensity in moderate-to-severe plaque psoriasis versus atopic dermatitis: a meta-analysis
. J Am Acad Dermatol
. 2017
;76
(6
):1198
–e1
. .94.
Lebwohl
MG
, Bachelez
H
, Barker
J
, Girolomoni
G
, Kavanaugh
A
, Langley
RG
, et al. Patient perspectives in the management of psoriasis: results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis survey
. J Am Acad Dermatol
. 2014
;70
(5
):871
–81.e1–30
. .95.
Szepietowski
JC
, Reich
A
. Pruritus in psoriasis: an update
. Eur J Pain
. 2016
;20
(1
):41
–6
. .96.
Amatya
B
, Wennersten
G
, Nordlind
K
. Patients’ perspective of pruritus in chronic plaque psoriasis: a questionnaire-based study
. J Eur Acad Dermatol Venereol
. 2008
;22
:822
–6
.97.
Yosipovitch
G
, Goon
A
, Wee
J
, Chan
YH
, Goh
CL
. The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis
. Br J Dermatol
. 2000
;143
(5
):969
–73
. .98.
Szepietowski
JC
, Reich
A
, Wiśnicka
B
. Itching in patients suffering from psoriasis
. Acta Dermatovenerol Croat
. 2002
;10
(4
):221
–6
.99.
Armstrong
AW
, Siegel
MP
, Bagel
J
, Boh
EE
, Buell
M
, Cooper
KD
, et al. From the medical board of the national psoriasis foundation: treatment targets for plaque psoriasis
. J Am Acad Dermatol
. 2017
;76
(2
):290
–8
. .100.
Bagel
J
, Gold
LS
. Combining topical psoriasis treatment to enhance systemic and phototherapy: a review of the literature
. J Drugs Dermatol
. 2017
;16
(12
):1209
–22
.101.
Stull
C
, Grossman
S
, Yosipovitch
G
. Current and emerging therapies for itch management in psoriasis
. Am J Clin Dermatol
. 2016
;17
(6
):617
–24
. .102.
Chang
SE
, Han
SS
, Jung
HJ
, Choi
JH
. Neuropeptides and their receptors in psoriatic skin in relation to pruritus
. Br J Dermatol
. 2007
;156
(6
):1272
–7
. .103.
Kalayciyan
A
, Aydemir
EH
, Kotogyan
A
. Experimental Koebner phenomenon in patients with psoriasis
. Dermatology
. 2007
;215
(2
):114
–7
. .104.
Nakamura
M
, Toyoda
M
, Morohashi
M
. Pruritogenic mediators in psoriasis vulgaris: comparative evaluation of itch-associated cutaneous factors
. Br J Dermatol
. 2003
;149
(4
):718
–30
. .105.
Ellis
CN
, Berberian
B
, Sulica
VI
, Dodd
WA
, Jarratt
MT
, Katz
HI
, et al. A double-blind evaluation of topical capsaicin in pruritic psoriasis
. J Am Acad Dermatol
. 1993
;29
(3
):438
–42
. .106.
Khoutorsky
A
, Price
TJ
. Translational control mechanisms in persistent pain
. Trends Neurosci
. 2018
;41
(2
):100
–14
. .107.
Woolf
CJ
. Pain amplification—a perspective on the how, why, when, and where of central sensitization
. J Appl Behav Res
. 2018
;23
(2
):e12124
. .108.
Henrich
F
, Magerl
W
, Klein
T
, Greffrath
W
, Treede
RD
. Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans
. Brain
. 2015
;138
(Pt 9
):2505
–20
. .© 2021 S. Karger AG, Basel
2021
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