Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized.

Keywords:
Ferulic acid antioxidant, Photoaging
1.
Mattila P, Kumpulainen J: Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection. J Agric Food Chem 2002; 50: 3660–3667.
2.
Parus A: Przeciwutleniające i farmakologiczne właściwości kwasów fenolowych. Post Fitoter 2013; 1: 48–53.
3.
Bezerra G, Pereira M, Ostrosky E, Barbosa E, Moura M, Ferrari M, Aragão C, Gomes A: Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR. J Therm Anal Calorim 2017; 127: 1683–1691.
4.
Aguilar-Hernández I, Afseth NK, López-Luke T, Contreras-Torres F, Wold JP, Ornelas-Soto N: Surface enhanced Raman spectroscopy of phenolic antioxidants: a systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid. Vib Spectrosc 2017; 89: 113–122.
5.
Tee-ngam P, Nunant N, Rattanarat P, Siangproh W, Chailapakul O: Simple and rapid determination of ferulic acid levels in food and cosmetic samples using paper-based platforms. Sensors 2013; 13: 13039–13053.
6.
Cota-Arriola O, Plascencia-Jatomea M, Lizardi-Mendoza J, Robles-Sánchez RM, Ezquerra-Brauer JM, Ruíz-García J, Vega-Acosta JR, Cortez-Rocha MO: Preparation of chitosan matrices with ferulic acid: physicochemical characterization and relationship on the growth of Aspergillus parasiticus. Journal of Food 2017; 15: 65–74.
7.
Moldovan M, Lahmar A, Bogdan C, Părăuan S, Tomuţă I, Crişan M: Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Med 2017; 90: 212–219.
8.
Rice-Evans CA, Miller NJ, Paganga G: Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 1996; 20: 933–956.
9.
Rice-Evans CA, Miller NJ, Paganga G: Antioxidant properties of phenolic compounds. Trends Plant Sci 1997; 2: 152–159.
10.
Lodovici M, Guglielmi F, Meoni M, Dolara P: Effect of natural phenolic acids on DNA oxidation in vitro. Food Chem Toxicol 2001; 39: 1205–1210.
11.
Masella R, Vari R, d’Archivio M, di Benedetto R, Matarrese P, Malorni W, Scazzocchio B, Giovannini C: Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr 2004; 134: 785–791.
12.
Masella R, Cantafora A, Modesti D, Cardilli A, Gennaro L, Bocca A, Coni E: Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. Redox Rep 1999; 4: 113–121.
13.
Kiewlicz J, Szymusiak H, Zieliński R: Symthesis. Thermal stability and antioxidant activity of long-chain alkyl esters od ferulic acid. Zywn Nauk Technol Ja 2015; 4: 188–200.
14.
Scharffetter-Kochanek K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L: Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 2000; 35: 307–316.
15.
Sheu S, Nauduri D, Anders MW: Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta 2006; 1762: 256–265.
16.
Higgins P, Dawson J, Walters M: The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease. Cardiovasc Psychiatry Neurol 2009; 2009: 1–9.
17.
Nile SH, Ko EY, Kim DH, Keum YS: Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity. Rev Bras Farmacogn 2016; 26: 50–55.
18.
Pluemsamran T, Onkoksoong T, Panich U: Caffeic acid and ferulic acid inhibit UVA-induced matrix metalloproteinase-1 through regulation of antioxidant defense system in keratinocyte HaCaT cells. Photochem Photobiol 2012; 88: 961–968.
19.
Hahn HJ, Kim KB, Bae S, Choi BG, An S, Ahn KJ, Kim SJ: Pretreatment of ferulic acid protects human dermal fibroblasts against ultraviolet A irradiation. Ann Dermatol 2016; 28: 740–748.
20.
Ambothi K, Nagarajan RP: Ferulic acid prevents ultraviolet-B radiation induced oxidative DNA damage in human dermal fibroblasts. Int J Nutr Pharmacol Neurol Dis 2014; 4: 203–213.
21.
Calabrese V, Calafato S, Puleo E, Cornelius C, Sapienza M, Morganti P, Mancuso C: Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes. Clin Dermatol 2008; 26: s.358–s.363.
22.
Inomata S, Matsunaga Y, Amano S, Takada K, Kobayashi K, Tsunenaga M: Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol 2003; 120: 128–134.
23.
Staniforth V, Huang W, Aravindaram K, Yang N: Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms. J Nutr Biochem 2012; 23: 443–451.
24.
Bian Y, Guo J, Majeed H, Zhu K, Guo X, Peng W, Zhou H: Ferulic acid renders protection to HEK293 cells against oxidative damage and apoptosis induced by hydrogen peroxide. In Vitro Cell Dev Biol Anim 2015; 51: 722–729.
25.
Kawaguchi Y, Tanaka H, Okada T, Konishi H, Takahashi M, Ito M, Asai J: Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts. Free Radic Biol Med 1997; 23: 162–165.
26.
Warren R, Gartstein V, Kligman AM, Montagna W, Allendorf RA, Ridder GM: Age, sunlight, and facial skin: a histologic and quantitative study. J Am Acad Dermatol 1991; 25: 751–760.
27.
Lin C, Chiu J, Wu I, Wang B, Pan C, Chen Y: Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1 alpha. J Nutr Biochem 2010; 21: 627–633.
28.
Yang G, Jiang J, Lu W: Ferulic acid exerts anti-angiogenic and anti-tumor activity by targeting fibroblast growth factor receptor 1-mediated angiogenesis. Int J Mol Sci 2015; 16: 24011–24031.
29.
Sangeeta D, Digvijay S, Pradeep TD, Rupesh S, Rahul T: Healing potential of ferulic acid on dermal wound in diabetic animals. Asian J Molec Model 2015; 1: 1–16.
30.
Ghaisas M, Kshirsagar S, Sahane R: Evaluation of wound healing activity of ferulic acid in diabetic rats. Int Wound J 2014; 11: 523–532.
31.
Oresajo C, Stephens T, Hino PD: Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. J Cosmet Dermatol 2008; 7: 290–297.
32.
Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR: A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol 2008; 59: 418–425.
33.
Saint-Leger D, Leveque JL, Verschoore M: The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid. J Cosmet Dermatol 2007; 6: 59–65.
34.
Saija A, Tomaino A, Lo Cascio R, Trombetta D, Proteggente A, De Pasquale A, Uccella N, Bonina F: Ferulic and caffeic acids as potential protective agents against photooxidative skin damage. J Sci Food Agric 1999; 79: 476–480.
35.
Saija A, Tomaino A, Lo Cascio R, Trombetta D, Proteggente A, De Pasquale A, Uccella N, Bonina F: In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. Int J Pharm 2000; 1: 39–47.
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2018
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