Background: Early detection of various types of nonmelanoma skin cancer has been a challenge in dermatology. Noninvasive examination procedures such as optical coherence tomography (OCT) play an increasingly important role, besides the established gold standard of histological tissue sample analysis. OCT is a noninvasive, cross-sectional, real-time technique that allows conclusions to be drawn with regard to the presence of pathologies. Objective: The objective of this study was to investigate whether it is possible to distinguish between different types of nonmelanoma skin cancer using OCT or not. Methods: A study population of a total of 25 cases, comprising 5 cases, each, of 5 tumor entities (i.e., basal cell carcinoma, superficial basal cell carcinoma, actinic keratosis, squamous cell carcinoma, and Bowen disease) was examined. Relevant lesions were scanned both centrally and peripherally in the multislice mode. All OCT images were blinded, randomized, analyzed, and evaluated by 2 clinicians experienced in OCT. Results: This study demonstrated that it is possible to determine correlations between various types of tumors and recurring tumor characteristics. Conclusion: This study showed that it is possible to distinguish between the different nonmelanoma skin cancers by using OCT, but further prospective studies have to be conducted to validate the sensitivity and specificity of the criteria.

Keywords:
Actinic keratosis, Basal cell carcinoma, Basalioma, Superficial basal cell carcinoma, Morbus Bowen, Squamous cell carcinoma, Optical coherence tomography
1.
Samarasinghe V, Madan V: Nonmelanoma skin cancer. J Cutan Aesthet Surg 2012; 5: 3–10.
2.
Wassef C, Rao BK: Uses of non-invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities. Int J Dermatol 2013; 52: 1481–1489.
3.
Krutmann J, Berking C, Berneburg M, Diepgen TL, Dirschka T, Szeimies M: New strategies in the prevention of actinic keratosis: a critical review. Skin Pharmacol Physiol 2015; 28: 281–289.
4.
Alawi SA, Kuck M, Wahrlich C, Batz S, Mc­Kenzie G, Fluhr JW, Lademann J, Ulrich M: Optical coherence tomography for presurgical margin assessment of non-melanoma skin cancer – a practical approach. Exp Dermatol 2013; 22: 547–551.
5.
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, Fujimoto JG: Optical coherence tomography. Science 1991; 254: 1178–1181.
6.
Swanson EA, Izatt JA, Hee MR, Huang D, Lin CP, Schuman JS, Puliafito CA, Fujimoto JG: In-vivo retinal imaging by optical coherence tomography. Opt Lett 1993; 18: 1864–1866.
7.
Lasave AF: Current interpretation of optical coherence tomography in the posterior pole. Arch Soc Esp Oftalmol 2016; 91: 3–9.
8.
Siedlecki D, Kowalik W, Kasprzak H: Optical coherence tomography as a tool for ocular dynamics estimation. Biomed Res Int 2015; 2015: 293693.
9.
Kirtane TS, Wagh MS: Endoscopic optical coherence tomography (OCT): advances in gastrointestinal imaging. Gastroenterol Res Pract 2014; 2014: 376367.
10.
Adler DC, Zhou C, Tsai TH, Lee HC, Becker L, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H: Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation. Endoscopy 2009; 41: 773–776.
11.
Xiong H, Guo Z, Zeng C, Wang L, He Y, Liu S: Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice. J Biomed Opt 2009; 14: 024029.
12.
South FA, Chaney EJ, Marjanovic M, Adie SG, Boppart SA: Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography. Biomed Opt Exp 2014; 5: 3417–3426.
13.
Grieve K, Mouslim K, Assayag O, Dalimier E, Harms F, Bruhat A, Boccara C, Antoine M: Assessment of sentinel node biopsies with full-field optical coherence tomography. Technol Cancer Res Treat 2016; 15: 266–274.
14.
Nolan RC, Narayana K, Galetta SL, Balcer LJ: Optical coherence tomography for the neurologist. Semin Neurol 2015; 35: 564–577.
15.
Knier B, Berthele A, Buck D, Schmidt P, Zimmer C, Muhlau M, Hemmer B, Korn T: Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination. Mult Scler 2016; 22: 893–900.
16.
Welzel J, Lankenau E, Birngruber R, Engelhardt R: Optical coherence tomography of the human skin. J Am Acad Dermatol 1997; 37: 958–963.
17.
Kuck M, Strese H, Alawi SA, Meinke MC, Fluhr JW, Burbach GJ, Krah M, Sterry W, Lademann J: Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing. Skin Res Technol 2014; 20: 1–7.
18.
Wahrlich C, Alawi SA, Batz S, Fluhr JW, Lademann J, Ulrich M: Assessment of a scoring system for basal cell carcinoma with multi-beam optical coherence tomography. J Eur Acad Dermatol Venereol 2015; 29: 1562–1569.
19.
Boone MA, Norrenberg S, Jemec GB, Del Marmol V: Imaging of basal cell carcinoma by high-definition optical coherence tomography: histomorphological correlation – a pilot study. Br J Dermatol 2012; 167: 856–864.
20.
Boone MA, Norrenberg S, Jemec GB, Del Marmol V: Imaging actinic keratosis by high-definition optical coherence tomography: histomorphologic correlation – a pilot study. Exp Dermatol 2013; 22: 93–97.
21.
Hussain AA, Themstrup L, Jemec GB: Optical coherence tomography in the diagnosis of basal cell carcinoma. Arch Dermatol Res 2015; 307: 1–10.
22.
Mogensen M, Thrane L, Jorgensen TM, Andersen PE, Jemec GB: Oct imaging of skin cancer and other dermatological diseases. J Biophotonics 2009; 2: 442–451.
23.
Coleman AJ, Richardson TJ, Orchard G, Uddin A, Choi MJ, Lacy KE: Histological correlates of optical coherence tomography in non-melanoma skin cancer. Skin Res Technol 2013; 19: 10–19.
24.
Mogensen M, Joergensen TM, Nurnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB: Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 2009; 35: 965–972.
25.
Olsen J, Themstrup L, De Carvalho N, Mogensen M, Pellacani G, Jemec GB: Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma. Photodiagnosis Photodyn Ther 2016; 16: 44–49.
26.
Schuh S, Kaestle R, Sattler E, Welzel J: Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer. Skin Res Technol 2016; 22: 395–405.
27.
Themstrup L, Banzhaf CA, Mogensen M, Jemec GB: Optical coherence tomography imaging of non-melanoma skin cancer undergoing photodynamic therapy reveals subclinical residual lesions. Photodiagnosis Photodyn Ther 2014; 11: 7–12.
28.
Schuh S, Kaestle R, Sattler EC, Welzel J: Optical coherence tomography of actinic keratoses and basal cell carcinomas – differentiation by quantification of signal intensity and lay er thickness. J Eur Acad Dermatol Venereol 2016; 30: 1321–1326.
29.
Marneffe A, Suppa M, Miyamoto M, Del Marmol V, Boone M: Validation of a diagnostic algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma by means of high-definition optical coherence tomography. Exp Dermatol 2016; 25: 684–687.
30.
Cao TT, Tey HL: High-definition optical coherence tomography – an aid to clinical practice and research in dermatology. J Dtsch Dermatol Ges 2015; 13: 886–890.
31.
De Carvalho N, Ciardo S, Cesinaro AM, Jemec GBE, Ulrich M, Welzel J, Holmes J, Pellacani G: In vivo micro-angiography by means of speckle-variance optical coherence tomography (SV-OCT) is able to detect microscopic vascular changes in naevus to melanoma transition. J Eur Acad Dermatol Venereol 2016; 30:E67–E68.
32.
Marvdashti T, Duan L, Aasi SZ, Tang JY, Bowden AKE: Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography. Biomed Opt Exp 2016; 7: 3721–3735.
33.
Boone M, Suppa M, Miyamoto M, Marneffe A, Jemec G, Del Marmol V: In vivo assessment of optical properties of basal cell carcinoma and differentiation of bcc subtypes by high-definition optical coherence tomography. Biomed Opt Exp 2016; 7: 2269–2284.
34.
Themstrup L, Pellacani G, Welzel J, Holmes J, Jemec GBE, Ulrich M: In vivo microvascular imaging of cutaneous actinic keratosis, Bowen’s disease and squamous cell carcinoma using dynamic optical coherence tomography. J Eur Acad Dermatol Venereol 2017; 31: 1655–1662.
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2018
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