Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. Methods: Thirty women (age 20–52 years) were recruited into a 12-week, double-blind, placebo-controlled intervention for CA-ext treatment, where they were randomly allocated to a left or right armpit group. At weekly intervals, axillary hair length was measured videometrically, the hair was shaved, and lotion was applied (to the contralateral axilla) twice daily via roll-on applicators containing either CA-ext or placebo. The primary endpoint of the study was hair growth. Results: Participants showed 22% (range 8–56%, p < 0.0001) reduced axillary hair growth with CA-ext compared to placebo, albeit delayed by 6 weeks. Participants were satisfied with the treatment and no apparent adverse effects were reported. The quantities of lotion used for each axilla were identical between test and placebo throughout the trial for each participant. Participants reported having shorter and finer armpit hair with the test lotion but disliked its smell, even though it was perfumed. The “free of irritation” description gained the highest questionnaire ratings. Conclusion: CA-ext in lotion is an efficacious inhibitor of axillary hair growth, the preparation was well accepted and matched the effectiveness of finasteride. Thus, with some refinement, it should provide an alternative pharmacological treatment for unwanted androgenic hair.

Barnard L, Ferriday D, Guenther N, Strauss B, Balen AH, Dye L: Quality of life and psychological well being in polycystic ovary syndrome. Hum Reprod 2007; 22: 2279–2286.
Dawber RP: Guidance for the management of hirsutism. Curr Med Res Opin 2005; 21: 1227–1234.
Balfour JA, McClellan K: Topical eflornithine. Am J Clin Dermatol 2001; 2: 197–202.
Mohammed GF: Topical Cyperus rotundus oil: a new therapeutic modality with comparable efficacy to Alexandrite laser photo-epilation. Aesthet Surg J 2014; 34: 298–305.
El-Kaream GFA: Role of Cyperus rotundus oil in decreasing hair growth. J Intercult Ethnopharmacol 2012; 1: 111–118.
Hamada K, Thornton MJ, Laing I, Messenger AG, Randall VA: The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5α-reductase deficiency. J Invest Dermatol 1996; 106: 1017–1022.
Itami S, Sonoda T, Kurata S, Takayasu S: Mechanism of action of androgen in hair follicles. J Dermatol Sci 1994; 7(suppl):S98–S103.
Shapiro J, Lui H: Treatments for unwanted facial hair. Skin Therapy Lett 2005; 10: 1–4.
Shenenberger DW, Utecht LM: Removal of unwanted facial hair. Am Fam Physician 2002; 66: 1907–1911.
Reanmongkol W, Subhadhirasakul S, Khaisombat N, Fuengnawakit P, Jantasila S, Khamjun A: Investigation the antinociceptive, antipyretic and anti-inflammatory activities of Curcuma aeruginosa Roxb. extracts in experimental animals. Songklanakarin J Sci Technol 2006; 28: 999–1008.
Kamazeri TS, Samah OA, Taher M, Susanti D, Qaralleh H: Antimicrobial activity and essential oils of Curcuma aeruginosa, Curcuma mangga, and Zingiber cassumunar from Malaysia. Asian Pac J Trop Med 2012; 5: 202–209.
Hossain CF, Al-Amin M, Sayem ASM, Siragee IH, Tunan AM, Hassan F, et al: Antinociceptive principle from Curcuma aeruginosa. BMC Complement Altern Med 2015; 15: 191.
Suphrom N, Pumthong G, Khorana N, Waranuch N, Limpeanchob N, Ingkaninan K: Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. Fitoterapia 2012; 83: 864–871.
Pumthong G, Asawanonda P, Varothai S, Jariyasethavong V, Triwongwaranat D, Suthi-pinittharm P, et al: Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J Dermatolog Treat 2012; 23: 385–392.
Srivilai J, Phimnuan P, Jaisabai J, Luangtoomma N, Waranuch N, Khorana N, et al: Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae: a randomised, double blinded trial. Phytomedicine 2017; 25: 29–38.
Suphrom N, Srivilai J, Pumthong G, Khorana N, Waranuch N, Limpeanchob N, et al: Stability studies of antiandrogenic compounds in Curcuma aeruginosa Roxb. extract. J Pharm Pharmacol 2014; 66: 1282–1293.
Noordzij M, Tripepi G, Dekker FW, Zoccali C, Tanck MW, Jager KJ: Sample size calculations: basic principles and common pitfalls. Nephrol Dial Transplant 2010; 25: 1388–1393.
Jackson J, Caro JJ, Caro G, Garfield F, Huber F, Zhou W, et al: The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism. Int J Dermatol 2007; 46: 976–981.
Boom RM: Emulsions: principles and preparation; in Aguilera JM, Lillford PJ (eds): Food Materials Science: Principles and Practice. New York, Springer, 2008, pp 305–339.
Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, Bombardier C: Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med 2006; 144: 364–367.
Team RC: R: A Language and Environment for Statistical Computing. Vienna, Foundation for Statistical Computing, 2009.
Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, et al: Finasteride in the treatment of men with androgenic alopecia. J Am Acad Dermatol 1998; 39: 578–579.
Wolf JE Jr, Shander D, Huber F, Jackson J, Lin CS, Mathes BM, et al: Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair. Int J Dermatol 2007; 46: 94–98.
Faloia E, Filipponi S, Mancini V, Di Marco S, Mantero F: Effect of finasteride in idiopathic hirsutism. J Endocrinol Invest 1998; 21: 694–698.
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