Background/Aims: Airborne pollutants, such as nano-sized soot particles, are increasingly being released into the environment as a result of growing population densities and industrialization. They can absorb organic and metal compounds with potential biological activity, such as polycyclic aromatic hydrocarbons and airborne pollen allergens. Local and systemic toxicities may be induced in the skin if the particulates release their harmful components upon dermal contact. Methods: In the present study, skin pretreatments with serum and/or shield as barrier formulations prior to exposure and washing with a cleanser subsequent to exposure were evaluated as a protection and decontamination strategy using laser scanning microscopy. Results: The results indicate that while the application of serum and a cleanser was insufficient for decontamination, the pretreatment with shield prior to nanoparticle exposure followed by washing led to the removal of a considerable amount of the carbon black particles. The combined application of serum and shield before the administration of carbon black particles and subsequent washing led to their elimination from the skin samples. Conclusion: The application of barrier-enhancing formulations in combination with a cleanser may reduce the penetration of harmful airborne particulates by preventing their adhesion to the skin and facilitating their removal by subsequent washing with the cleanser.

1.
Nowack B, Bucheli TD: Occurrence, behavior and effects of nanoparticles in the environment. Environ Pollut 2007;150:5-22.
2.
Vierkotter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Kramer U, Krutmann J: Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 2010;130:2719-2726.
3.
Campbell CS, Contreras-Rojas LR, Delgado-Charro MB, Guy RH: Objective assessment of nanoparticle disposition in mammalian skin after topical exposure. J Control Release 2012;162:201-207.
4.
Lademann J, Richter H, Schaefer UF, Blume-Peytavi U, Teichmann A, Otberg N, Sterry W: Hair follicles - a long-term reservoir for drug delivery. Skin Pharmacol Physiol 2006;19:232-236.
5.
Castano-Vinyals G, Cantor KP, Malats N, Tardon A, Garcia-Closas R, Serra C, Carrato A, Rothman N, Vermeulen R, Silverman D, Dosemeci M, Kogevinas M: Air pollution and risk of urinary bladder cancer in a case-control study in Spain. Occup Environ Med 2008;65:56-60.
6.
Beelen R, Hoek G, van den Brandt PA, Goldbohm RA, Fischer P, Schouten LJ, Armstrong B, Brunekreef B: Long-term exposure to traffic-related air pollution and lung cancer risk. Epidemiology 2008;19:702-710.
7.
Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V: Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2005;2:10.
8.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A: Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 2003;111:455-460.
9.
Vierkotter A: Environmental pollution and skin aging (in German). Hautarzt 2011;62:577-578, 580-581.
10.
Utell MJ, Frampton MW: Acute health effects of ambient air pollution: the ultrafine particle hypothesis. J Aerosol Med 2000;13:355-359.
11.
Folster-Holst R, Galecka J, Weissmantel S, Dickschat U, Rippke F, Bohnsack K, Werfel T, Wichmann K, Buchner M, Schwarz T, Vogt A, Lademann J, Meinke MC: Birch pollen influences the severity of atopic eczema - prospective clinical cohort pilot study and ex vivo penetration study. Clin Cosmet Investig Dermatol 2015;8:539-548.
12.
Wester RC, Maibach HI: Dermal decontamination and percutaneous absorption; in Bronaugh RL Maibach HI (eds): Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methodology. Boca Raton, Taylor & Francis Group, 2005.
13.
Moody RP, Maibach HI: Skin decontamination: importance of the wash-in effect. Food Chem Toxicol 2006;44:1783-1788.
14.
Wester RC, Maibach HI: Advances in percutaneous absorption; in Drill VA, Lazar P (eds): Cutaneous Toxicity. New York, Raven Press, 1984.
15.
Teichmann A, Jacobi U, Waibler E, Sterry W, Lademann J: An in vivo model to evaluate the efficacy of barrier creams on the level of skin penetration of chemicals. Contact Dermatitis 2006;54:5-13.
16.
Meyer LE, Lademann J: Application of laser spectroscopic methods for in vivo diagnostics in dermatology. Laser Phys Lett 2007;4:754-760.
17.
English JS, Dawe RS, Ferguson J: Environmental effects and skin disease. Br Med Bull 2003;68:129-142.
18.
Zhai H, Maibach HI: Barrier creams - skin protectants: can you protect skin? J Cosmet Dermatol 2002;1:20-23.
19.
Treffel P, Gabard B, Juch R: Evaluation of barrier creams: an in vitro technique on human skin. Acta Derm Venereol 1994;74:7-11.
20.
Boman A, Mellstrom G: Percutaneous absorption of 3 organic solvents in the guinea pig. III. Effect of barrier creams. Contact Dermatitis 1989;21:134-140.
21.
Frosch PJ, Kurte A: Efficacy of skin barrier creams. IV. The repetitive irritation test (RIT) with a set of 4 standard irritants. Contact Dermatitis 1994;31:161-168.
22.
Mathias CG: Prevention of occupational contact dermatitis. J Am Acad Dermatol 1990;23:742-748.
23.
Davidson CL: Occupational contact dermatitis of the upper extremity. Occup Med 1994;9:59-74.
24.
Frosch PJ, Schulze-Dirks A, Hoffmann M, Axthelm I: Efficacy of skin barrier creams. II. Ineffectiveness of a popular “skin protector” against various irritants in the repetitive irritation test in the guinea pig. Contact Dermatitis 1993;29:74-77.
25.
Meinke MC, Schanzer S, Richter H, Rippke F, Filbry A, Bohnsack K, Patzelt A, Lademann J: Prevention of cutaneous penetration and CD1c+ uptake of pollen allergens by a barrier-enhancing formulation. Skin Pharmacol Physiol 2016;29:71-75.
26.
Lademann J, Richter H, Baier G, Landfester K, Frazier L, Gefeller H, Knorr F: Decontamination of the skin exposed to nanocarriers using an absorbent textile material and PEG-12 dimethicone. Laser Phys Lett 2014;11:115603.
27.
Lademann J, Schaefer H, Otberg N, Teichmann A, Blume-Peytavi U, Sterry W: Penetration of microparticles into human skin. Hautarzt 2004;55:1117-1119.
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