Background: The antioxidant status of the human skin provides protection against the destructive action of free radicals. Most antioxidants cannot be synthesized by the human organism itself, but have to be ingested with a healthy nutrition rich in fruit and vegetables. The Korean cuisine is known to be one of the healthiest worldwide. This binational study investigated the cutaneous carotenoid concentrations in German subjects, South Korean subjects and immigrant Korean subjects resident in Germany and examined whether dietary- and lifestyle-related differences are reflected in the cutaneous carotenoid concentrations. Methods: Measurements of the carotenoid concentrations of 714 healthy volunteers were performed using a non-invasive spectroscopic measurement system based on reflectance spectroscopy. Results: In the present study South Korean residents showed a significantly higher antioxidant status than both native German residents and Korean immigrants living in Germany (p < 0.001). The first generation of Korean immigrants to Germany over the age of 50 mostly preserved Korean dietary habits, showing significantly higher concentrations (p < 0.001) than the German-born second and third Korean generations under the age of 50. Conclusion: The results of the study indicate that a healthy nutrition alone does not provide a high antioxidant status unless the stress exposure can be reduced simultaneously.

Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
Droge W: Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
Barouki R: Ageing free radicals and cellular stress. Med Sci (Paris) 2006;22:266-272.
Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS: Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal 2013;6:ra8.
Knight JA: The biochemistry of aging. Adv Clin Chem 2000;35:1-62.
Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC: Discovering the link between nutrition and skin aging. Dermatoendocrinol 2012;4:298-307.
Cui J, Le G, Yang R, Shi Y: Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: a microarray analysis. Cell Immunol 2009;260:44-50.
Sander CS, Chang H, Hamm F, Elsner P, Thiele JJ: Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 2004;43:326-335.
Bohm F, Edge R, Truscott G: Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: potential effects for human health. Mol Nutr Food Res 2012;56:205-216.
Torbergsen AC, Collins AR: Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr 2000;39:80-85.
Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BW, Williams GR, Atkinson H, Martin A, Guralnik JM, Ferrucci L: Antioxidants and physical performance in elderly persons: The Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 2004;79:289-294.
Agudo A, Cabrera L, Amiano P, Ardanaz E, Barricarte A, Berenguer T, Chirlaque MD, Dorronsoro M, Jakszyn P, Larranaga N, Martinez C, Navarro C, Quiros JR, Sanchez MJ, Tormo MJ, Gonzalez CA: Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). Am J Clin Nutr 2007;85:1634-1642.
Rao AV, Rao LG: Carotenoids and human health. Pharmacol Res 2007;55:207-216.
Halvorsen BL, Carlsen MH, Phillips KM, Bohn SK, Holte K, Jacobs DR Jr, Blomhoff R: Content of redox-active compounds (i.e. antioxidants) in foods consumed in the United States. Am J Clin Nutr 2006;84:95-135.
Muller H, Bub A, Watzl B, Rechkemmer G: Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods. Eur J Nutr 1999;38:35-44.
Meinke MC, Darvin ME, Vollert H, Lademann J: Bioavailability of natural carotenoids in human skin compared to blood. Eur J Pharm Biopharm 2010;76:269-274.
Lademann J, Meinke MC, Sterry W, Darvin ME: Carotenoids in human skin. Exp Dermatol 2011;20:377-382.
Nouveau-Richard S, Yang Z, Mac-Mary S, Li L, Bastien P, Tardy I, Bouillon C, Humbert P, de Lacharrière O: Skin ageing: a comparison between Chinese and European populations. J Dermatol Sci 2005;40:187-193.
Roh K, Kim D, Ha S, Ro Y, Kim J, Lee H: Pigmentation in Koreans: study of the differences from Caucasians in age, gender and seasonal variations. Br J Dermatol 2001;144:94-99.
Chung JH: Photoaging in Asians. Photodermatol Photoimmunol Photomed 2003;19:109-121.
Luther N, Darvin ME, Sterry W, Lademann J, Patzelt A: Ethnic differences in skin physiology, hair follicle morphology and follicular penetration. Skin Pharmacol Physiol 2012;25:182-191.
Yang EJ, Chung HK, Kim WY, Bianchi L, Song WO: Chronic diseases and dietary changes in relation to Korean Americans' length of residence in the United States. J Am Diet Assoc 2007;107:942-950.
Park SY, Murphy SP, Sharma S, Kolonel LN: Dietary intakes and health-related behaviours of Korean American women born in the USA and Korea: the Multiethnic Cohort Study. Public Health Nutr 2005;8:904-911.
Lutsey PL, Diez Roux AV, Jacobs DR Jr, Burke GL, Harman J, Shea S, Folsom AR: Associations of acculturation and socioeconomic status with subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis. Am J Public Health 2008;98:1963-1970.
Lee Y, Choi J, Kwon M, Kim J, Suh H, Song Y: Isolation and identification of active principle in Chinese cabbage kimchi responsible for antioxidant effect. Korean J Food Sci Technol 2004;36:129-133.
Choi IH, Noh JS, Han J-S, Kim HJ, Han E-S, Song YO: Kimchi, a fermented vegetable, improves serum lipid profiles in healthy young adults: randomized clinical trial. J Med Food 2013;16:223-229.
Pugliese A, O'Callaghan Y, Tundis R, Galvin K, Menichini F, O'Brien N, Loizzo MR: In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chili peppers (Capsicum annuum). Eur J Nutr 2014;53:501-510.
Lordan S, Ross RP, Stanton C: Marine bioactives as functional food ingredients: potential to reduce the incidence of chronic diseases. Mar Drugs 2011;9:1056-1100.
Park EJ, Pezzuto JM: Antioxidant marine products in cancer chemoprevention. Antioxid Redox Signal 2013;19:115-138.
Kim S, Moon S, Popkin BM: The nutrition transition in South Korea. Am J Clin Nutr 2000;71:44-53.
Lee MJ, Popkin BM, Kim S: The unique aspects of the nutrition transition in South Korea: the retention of healthful elements in their traditional diet. Public Health Nutr 2002;5:197-203.
Kwak CS, Lee MS, Oh SI, Park SC: Discovery of novel sources of vitamin B12 in traditional Korean foods from nutritional surveys of centenarians. Curr Gerontol Geriatr Res 2010;2010:374897.
Lee MS, Woo MK, Kwak CS, Oh SI, Park SC: Analysis of traditional Korean food patterns according to the healthy longevity diet based on the database of favorite Korean foods. Ann NY Acad Sci 2001;928:348.
Slimani N, Fahey M, Welch A, Wirfält E, Stripp C, Bergström E, Linseisen J, Schulze MB, Bamia C, Chloptsios Y, Veglia F, Panico S, Bueno-de-Mesquita HB, Ocké MC, Brustad M, Lund E, González CA, Barcos A, Berglund G, Winkvist A, Mulligan A, Appleby P, Overvad K, Tjønneland A, Clavel-Chapelon F, Kesse E, Ferrari P, Van Staveren WA, Riboli E: Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project. Public Health Nutr 2007;5:1311.
Darvin ME, Sandhagen C, Koecher W, Sterry W, Lademann J, Meinke MC: Comparison of two methods for noninvasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy. J Biophotonics 2012;5:550-558.
Haag SF, Taskoparan B, Darvin ME, Groth N, Lademann J, Sterry W, Meinke MC: Determination of the antioxidative capacity of the skin in vivo using resonance Raman and electron paramagnetic resonance spectroscopy. Exp Dermatol 2011;20:483-487.
Stahl W, Heinrich U, Jungmann H, von Laar J, Schietzel M, Sies H, Tronnier H: Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J Nutr 1998;128:903-907.
Schönwälder K: Why Germany's guest workers were largely Europeans: the selective principles of post-war labour recruitment policy. Ethn Racial Stud 2004;27:248-265.
Meinke MC, Lauer A, Taskoparan B, Gersonde I, Lademann J, Darvin ME: Influence on the carotenoid levels of skin arising from age, gender, body mass index in smoking/non-smoking individuals. Free Radic Antioxid 2011;1:15-20.
World Health Organization: WHO report on the global tobacco epidemic, 2011: warning about the dangers of tobacco. WHO Library Cataloguing-in-Publication Data 2011:130 (online).
Statistisches Bundesamt Zweigstelle Bonn destinies BN: Mikrozensus - Fragen zur Gesundheit. 2009.
Hähner-Rombach S, Schweikardt C: Quellen zur Geschichte der Krankenpflege: mit Einführungen und Kommentaren. Mabuse-Verlag, 2008.
Kim E, Wolpin S: The Korean American family: adolescents versus parents acculturation to American culture. J Cult Divers 2008;15:108-116.
Yang CK: Age-related changes in sleep/wake patterns among Korean teenagers. Pediatrics 2005;115:250-256.
Gelfand MJ, Raver JL, Nishii L, Leslie LM, Lun J, Lim BC, Duan LL, Almaliach A, Ang S, Arnadottir J, Aycan Z, Boehnke K, Boski P, Cabecinhas R, Chan D, Chhokar J, D'Amato A, Ferrer M, Fischlmayr IC, Fischer R, Fulop M, Georgas J, Kashima ES, Kashima Y, Kim K, Lempereur A, Marquez P, Othman R, Overlaet B, Panagiotopoulou P, Peltzer K, Perez-Florizno LR, Ponomarenko L, Realo A, Schei V, Schmitt M, Smith PB, Soomro N, Szabo E, Taveesin N, Toyama M, Van de Vliert E, Vohra N, Ward C, Yamaguchi S: Differences between tight and loose cultures: a 33-nation study. Science 2011;332:1100-1104.
OECD: OECD Labour Force Statistics. 2011.
OECD: Suicides. OECD Factbook 2013: Economic, Environmental and Social Statistics. OECD, 2013.
Kim S-W, Yoon J-S: Suicide, an urgent health issue in Korea. J Korean Med Sci 2013;28:345-347.
Normile D: Public health. Korea tackles a mushrooming problem. Science 2012;338:1026-1027.
Park S-G, Min K-B, Chang S-J, Kim H-C, Min J-Y: Job stress and depressive symptoms among Korean employees: the effects of culture on work. Int Arch Occup Environ Health 2008;82:397-405.
Choi S-M, Park YS, Yoo J-H, Kim G-Y: Occupational stress and physical symptoms among family medicine residents. Korean J Fam Med 2013;34:49.
KCDC Division of Health and Nutrition Examination Surveys MDoSHaS: 2011 online survey on youth health status concerning smoking, drinking and eating habits and sleep patterns of adolescents. 2011.
Boehm JK, Williams DR, Rimm EB, Ryff C, Kubzansky LD: Association between optimism and serum antioxidants in the midlife in the United States study. Psychosom Med 2012;75:2-10.
Kromeyer-Hauschild K, Glasser N, Zellner K: Percentile curves for skinfold thickness in 7- to 14-year-old children and adolescents from Jena, Germany. Eur J Clin Nut 2012;66:613-621.
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