Psoriasis is a clinical skin disease that is characterized by erythematous scaling plaques and involves the extensor site of the extremities, the scalp and other surfaces of the skin. Tea tree oil (TTO) is considered an essential oil, obtained by steam distillation of the leaves and terminal branchlets of Melaleuca alternifolia. Notably,terpinen-4-ol, the major TTO constituent, has been found to have potent anti-inflammatory properties. It is suggested that terpinen-4-ol may be a novel potential agent against psoriasis. This article draws attention to the antipsoriatic effect of TTO and provides a theoretical molecular approach.

1.
Bari L, Bacsa S, Sonkoly E, Bata-Csörgo Z, Kemény L, Dobozy A, Széll M: Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells. Arch Dermatol Res 2011;303:745–752.
2.
Ghiasi M, Nouri M, Abbasi A, Hatami P, Abbasi MA, Nourijelyani K: Psoriasis and increased prevalence of hypertension and diabetes mellitus. Indian J Dermatol 2011;56:533–536.
3.
Montesu M, Addis G, Satta R, Cottoni F: Adverse reactions during biological drug therapy in psoriasis: clinical series and a review of the literature. G Ital Dermatol Venereol 2011;146:273–281.
4.
Balato A, Lembo S, Cirillo T, Megna M, Raimondo A, Di Costanzo L: Anti-tumor necrosis factor-α therapy in the management of psoriasis and B-chronic lymphocytic leukemia. Case Rep Dermatol 2011;3:60–63.
5.
Renne J, Schäfer V, Werfel T, Wittmann M: Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation. Br J Dermatol 2010;162:1198–2205.
6.
Ferran M, Ferran M, Galván AB, Giménez-Arnau A, Giménez-Arnau A, Pujol RM, Pujol RM, Santamaría-Babi LF, Santamaría-Babi LF: Production of interleukin-8 by circulating CLA+ T cells with skin tropism in patients with psoriasis and in healthy controls. Actas Dermosifiliogr 2010;101:151–155.
7.
Michel B, Chantreuil J, Guilhou JJ, Crastes de Paulet A, Meynadier J: Prostaglandin biosynthesis in psoriatic epidermis (author’s transl). Ann Dermatol Venereol 1980;107:889–893.
8.
Hern S, Stanton AW, Mellor R, Levick JR, Mortimer PS: Control of cutaneous blood vessels in psoriatic plaques. J Invest Dermatol 1999;113:127–132.
9.
Carson CF, Riley TV: Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil. Contact Dermatitis 2001;45:65–67.
10.
Mondello F, De Bernardis F, Girolam A, Cassone A, Salvatore G: In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC Infect Dis 2006;6:158.
11.
Carson CF, Hammer KA, Riley TV: Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 2006;19:50–62.
12.
Martin KW, Ernst E: Herbal medicines for treatment of bacterial infections: a review of controlled clinical trials. J Antimicrob Chemother 2003;51:241–246.
13.
Enshaieh S, Jooya A, Siadat AH, Iraji F: The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007;73:22–25.
14.
Bakker CV, Blömeke B, Coenraads PJ, Schuttelaar ML: Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients. Contact Dermatitis 2011;65:240–241.
15.
Khokhra S, Diwan A: Microemulsion based transdermal drug delivery of tea tree oil. Int J Drug Dev Res 2011;3:191–198.
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