The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD+), adenosine precursor, in 37 patients suffering from psoriasis. As NAD+ is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of topical NAD+ composition. In each patient, two matching plaques were selected for the study. Topical treatment with 1 or 0.3% NAD+ in Vaseline ointment administered twice daily was compared with overnight therapy with 0.1% anthralin applied for 12 h and placebo. The enzymatic method was applied to determine the stability of NAD+ in Vaseline ointment. After a 4-week application, the reduction in erythema, infiltration and desquamation caused by 1 or 0.3% topical NAD+ composition was similar to the reduction caused by 0.1% anthralin. It was demonstrated that NAD+ underwent a considerable decomposition at room temperature, while it was sufficiently stable at 5°C; thus, for a longer use the agent should be stored at fridge temperature. NAD+ therapy combines good efficacy, cosmetic acceptability and convenient twice-daily application.

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