... Deep brain stimulation Subthalamic nucleus Asleep General anaesthesia Parkinson Since the approval of deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) back in 2002 [ 1 ], the field has experienced various substantial improvements [ 2 ]. Among them, direct targeting...

...Rozemarije A. Holewijn; Yarit Wiggerts; Maarten Bot; Dagmar Verbaan; Rob M.A. de Bie; Rick Schuurman; Pepijn van den Munckhof Introduction: We present our surgical complications resulting in neurological deficit or additional surgery during 25 years of DBS of the subthalamic nucleus (STN...

...Marwan Hariz; Laura Cif; Patric Blomstedt Background: The advent of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease 30 years ago has ushered a global breakthrough of DBS as a universal method for therapy and research in wide areas of neurology and psychiatry...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Registration CT MRI Subthalamic nucleus NIH Subthalamic deep brain stimulation (DBS) is an established therapy for the motor symptoms of Parkinson’s disease...

... Microelectrode recording Subthalamic nucleus Targeting accuracy Targeting error Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an evidence-based treatment option in Parkinson’s disease [ 1 ]. Efficacy of DBS therapy is critically influenced by the anatomic location...

.... Leads were implanted in the subthalamic nucleus (STN) according to probabilistic stereotactic coordinates with a surgical robot under O-arm © imaging guidance under either general anesthesia without microelectrode recordings (MER) (20 patients, asleep group) or local anesthesia with MER and clinical...

...Alexis de Roquemaurel; Thomas Wirth; Nirosen Vijiaratnam; Francisca Ferreira; Ludvic Zrinzo; Harith Akram; Thomas Foltynie; Patricia Limousin Introduction: While deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been extensively used for more than 20 years in Parkinson’s disease (PD...

...Maria Sheila Guimarães Rocha; Julian Letícia de Freitas; Iara Amorim Torres; Paula Camila Alves Matos; Paulo Roberto Terzian; João Fellipe Santos Tatsch; Fabio Godinho Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficient treatment of primary dystonia. Few...

...Erik Bolier; Maarten Bot; Pepijn van den Munckhof; Gian Pal; Sepehr Sani; Leo Verhagen Metman Introduction: The intersection of Bejjani’s line with the well-delineated medial subthalamic nucleus (STN) border on MRI has recently been proposed as an individualized reference in subthalamic deep brain...

... for Parkinson’s disease (PD). A stimulation sweet spot at the interface between the motor and associative clusters of the subthalamic nucleus (STN) has recently been postulated. The aim of this study was to analyze the available clustering methods for the STN and their correlation to outcome. Methods...

...) is established as the most frequent target in the management of the dystonic symptoms. We report our experience with subthalamic nucleus (STN) DBS in 3 patients with post-infarct dystonia, in whom GPi DBS was not confidently possible due to the presence of striatal infarcts. Two patients had unilateral STN DBS...

...Witold H. Polanski; Amir Zolal; Kerim Hakan Sitoci-Ficici; Patrick Hiepe; Gabriele Schackert; Stephan B. Sobottka Introduction: Various automatic segmentation algorithms for the subthalamic nucleus (STN) have been published recently. However, most of the available software tools are not approved...

...Luka Milosevic; Philippe De Vloo; Robert Gramer; Suneil K. Kalia; Alfonso Fasano; Milos R. Popovic; William D. Hutchison The authors report the case of an elderly male in his 60s who, after 5 months of efficacious treatment with chronic deep brain stimulation of the subthalamic nucleus (STN-DBS...

...Henrieke L. Frequin; Maarten Bot; José Dilai; Marije N. Scholten; Miranda Postma; Lodewijk J. Bour; Maria Fiorella Contarino; Rob M.A. de Bie; P. Rick Schuurman; Pepijn van den Munckhof Introduction: For deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) in Parkinson’s disease...

...Patrick S. Drummond; Michael H. Pourfar; Travis C. Hill; Alon Y. Mogilner; Douglas S. Kondziolka Introduction: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) has been shown to reliably improve several symptoms of Parkinson’s disease (PD) in appropriately selected patients...

...Viswas Dayal; Harith Akram; Ludvic Zrinzo; Patricia Limousin; Thomas Foltynie In this article, we use a case to illustrate and discuss some practically important learning points about programming subthalamic nucleus deep brain stimulation for Parkinson’s disease patients and highlight clinically...

...Maarten Bot; Okker Verhagen; Matthan Caan; Wouter V. Potters; Y. Dilai; Vincent J.J. Odekerken; Joke M. Dijk; Rob M.A. de Bie; P. Richard Schuurman; Pepijn van den Munckhof Background: 7.0-T T2-weighted MRI offers excellent visibility of the subthalamic nucleus (STN), which is used as a target...

... prediction of both the therapeutic effect and side effects of the surgery. Methods: The retrospective intraoperative data from 30 patients operated on in the subthalamic nucleus were used to train an artificial neural network to predict the deep brain stimulation outcome. A leave-one-out validation...

...Manish Ranjan; Alexandre Boutet; David S. Xu; Christopher S. Lozano; Rajeev Kumar; Alfonso Fasano; Walter Kucharczyk; Andres M. Lozano Background: The visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) is variable. Studies of the contribution of patient-related...

... replacement. We wish to determine if there is any significant difference in longevity of 2 commonly used IPG systems; the Medtronic Kinetra, and the Medtronic Activa Primary Cell (PC), which has come to replace it. Methods: All patients with bilateral Subthalamic Nucleus stimulators for PD performed in our...