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Keywords: MPTP
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Journal Articles
Stereotact Funct Neurosurg (2002) 77 (1-4): 108–115.
Published Online: 07 October 2002
...-tetrahydropyridine (MPTP) was systemically injected in monkeys with prior PPN lesioning. These monkeys developed no, or if any, very mild parkinsonism. PPN lesioning was supposed to have protected the nigral neurons from the MPTP- toxicity. The PPN facilitates the motor system through its nigral projection...
Journal Articles
Stereotact Funct Neurosurg (2002) 77 (1-4): 91–97.
Published Online: 07 October 2002
...Masaru Matsumura Early in the1960s the primate model of Parkinson’s disease was first introduced by placing an electrolytic lesion in the midbrain. In the 1980s, a dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was accidentally shown to induce parkinsonism in humans...
Journal Articles
Stereotact Funct Neurosurg (1994) 62 (1-4): 98–102.
Published Online: 11 April 1995
... have studied the antiparkinsonian efficacy of STN lesions in MPTP-treated monkeys. Four rhesus monkeys were made parkinsonian by MPTP (i.v. 0.15 ± 1 mg/kg) administration over 3 months. Unilateral subthalamotomy (kainic acid) was performed by a standard stereotactic method. Severity was rated from 0...
Journal Articles
Stereotact Funct Neurosurg (1990) 54-55 (1-8): 337–341.
Published Online: 28 November 1990
.... Parkinson's disease MPTP Autotransplantation Superior cervical ganglion Behavior Monkey Proceedings of the Xth Meeting of the World Society for Stereotactic and Functional Neurosurgery, Maebashi, Japan. October 1989 Stereotact Funct Neurosurg 1990:54+55:337-341 Transplantation of Autologous Superior...