...Ingeborg van Kroonenburgh; Sonny K.H. Tan; Petra Heiden; Jochen Wirths; Georgios Matis; Harald Seifert; Veerle Visser-Vandewalle; Pablo Andrade Introduction: Neuromodulation using deep brain stimulation (DBS), spinal cord stimulation (SCS), and peripheral nerve field stimulation (PNFS) to treat...

...Rasmus Stenmark Persson; Anders Fytagoridis; Maxim Ryzhkov; Marwan Hariz; Patric Blomstedt Introduction: Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease (PD) and other movement disorders. The ventral intermediate nucleus of the thalamus is considered as the target...

...Marwan Hariz; Laura Cif; Patric Blomstedt Background: The advent of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson’s disease 30 years ago has ushered a global breakthrough of DBS as a universal method for therapy and research in wide areas of neurology and psychiatry...

...Henry M. Skelton; David M. Brandman; Katie Bullinger; Faical Isbaine; Robert E. Gross Introduction: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) and responsive neurostimulation (RNS) of the hippocampus are the predominant approaches to brain stimulation for treating...

...Kaylee R. Henry; Milina Michelle Miulli; Noa B. Nuzov; Mark J. Nolt; Joshua M. Rosenow; Behzad Elahi; Julie Pilitsis; Laleh Golestanirad Introduction: Directional deep brain stimulation (DBS) leads have become widely used in the past decade. Understanding the asymmetric stimulation provided...

...Erik H. Middlebrooks; Shengzhen Tao; Xiangzhi Zhou; Elena Greco; Erin M. Westerhold; Philip W. Tipton; Alfredo Quinones-Hinojosa; Sanjeet S. Grewal; Vishal Patel Background: Advances in MRI technology have increased interest in direct targeting for deep brain stimulation (DBS). Various imaging...

...Kristin M Kostick-Quenet; Lavina Kalwani; Laura N Torgerson; Katrina Munoz; Clarissa Sanchez; Eric A Storch; J. S. Blumenthal-Barby; Gabriel Lazáro-Muñoz Introduction: Pediatric deep brain stimulation (pDBS) is commonly used to manage treatment-resistant primary dystonias with favorable results...

...Melissa M.J. Chua; Aaron E.L. Warren; G. Rees Cosgrove; John D. Rolston Introduction: Prompt dissemination of clinical trial results is essential for ensuring the safety and efficacy of intracranial neurostimulation treatments, including deep brain stimulation (DBS) and responsive neurostimulation...

...Aaron Elliott Rusheen; Michael A. Jensen; Nicholas M. Gregg; Timothy J. Kaufmann; Jamie J VanGompel; Kendall H. Lee; Bryan T Klassen; Kai Joshua Miller Background: Implantable pulse generators (IPGs) store energy and deliver electrical impulses for deep brain stimulation (DBS) to treat neurological...

...Rishabh Gupta; Danika Paulo; Lili Sun; Fei Ye; Kaltra Dhima; Sarah K. Bick Background: Essential tremor (ET) patients present with both motor and non-motor symptoms including depression. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is used to treat motor symptoms...

... Deep brain stimulation Microelectrode recording Subthalamic nucleus Targeting accuracy Targeting error Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an evidence-based treatment option in Parkinson’s disease [ 1 ]. Efficacy of DBS therapy is critically influenced...

...Jakov Tiefenbach; Leonardo Favi Bocca; Olivia Hogue; Neil Nero; Kenneth B Baker; Andre G. Machado Background: Deep brain stimulation (DBS) is a neurosurgical treatment used for the treatment of movement disorders. Surgical and perioperative complications, although infrequent, can result...

..., ambulatory LFP was recorded from patients who underwent sensing-enabled deep brain stimulation (DBS, 2 participants) or responsive neurostimulation (RNS, 3 participants) targeting the anterior nucleus of the thalamus (ANT, 2 electrodes), centromedian nucleus (CM, 7 electrodes), or medial pulvinar (PuM, 1...

... imaging (MRI) of the basal ganglia during stereotactic neurosurgery. Methods: This pilot study was conducted in 4 patients with Parkinson’s disease (PD) who underwent MRI-guided deep brain stimulation of the globus pallidus internus (GPi). CSF was obtained via lumbar puncture after general anesthesia...

...Yara Rosalie Willems; Niels Anthony van der Gaag; Kuan Hua Kho; Øystein Vesterli Tveiten; Marie Therese Krüger; Martin Jakobs; ESSFN Young Functional Neurosurgeons taskforce Introduction: The success of deep brain stimulation (DBS) treatment depends on several factors, including proper patient...

...Michael Schulder; Akash Mishra; Antonios Mammis; Andres Horn; Alexandre Boutet; Patric Blomstedt; Stephan Chabardes; Oliver Flouty; Andres M. Lozano; Joseph S. Neimat; Francisco Ponce; Philip A. Starr; Joachim K. Krauss; Marwan Hariz; Jin Woo Chang Background: Deep brain stimulation has become...

...Noa B. Nuzov; Bhumi Bhusal; Kaylee R. Henry; Fuchang Jiang; Jasmine Vu; Joshua M. Rosenow; Julie G. Pilitsis; Behzad Elahi; Laleh Golestanirad Introduction: Deep brain stimulation (DBS) is a common treatment for a variety of neurological and psychiatric disorders. Recent studies have highlighted...

...; Flavia Venetucci Gouveia Posterior hypothalamic-deep brain stimulation (pHyp-DBS) has been reported as a successful treatment for reducing refractory aggressive behaviors in patients with distinct primary diagnoses. Here, we report on a patient with cri du chat syndrome presenting severe self-injury...

...Alexandra Boogers; Tine Van Bogaert; Jana Peeters; Ugur Kilic; Stefan Sunaert; Wim Vandenberghe; Myles Mc Laughlin; Philippe De Vloo; Bart Nuttin Deep brain stimulation is an established treatment option for both essential tremor (ET) and Parkinson’s disease (PD), although typically targeting...

... the advent of the basal ganglia model of PD. Modern Deep Brain Stimulation (DBS) that started in the thalamus for tremor was the result of an observation by Benabid that intraoperative high-frequency stimulation during a thalamotomy reduced tremor. Both the discoveries of the anterior limbic subthalamic...