Volume measurement of the amygdalohippocampus on MRI may provide important information for epilepsy surgery. This study investigated the reliability of direct volume assessment (DVA) versus computer-assisted measurement (CAM) of amygdalohippocampus. DVA was carried out by counting the number of squares occupied by amygdalohippocampus in a transparent mm2 overlay used on both sagittal and coronal films. CAM was achieved using the ''thresholding and tracing'' automated technique. Seventeen patients undergoing language-dominant left temporal lobectomy were studied. Mean volume as determined by the CAM was 4.99 ± 1.31. In DVA, the mean volume was 5.05 ± 1.23 (r = 0.974). Reproducibility of the volume measurement was tested by repeating measurements 5 times on 5 patient samples of amygdalohippocampal complex in DVA, and 3 times on 4 samples in CAM. The mean coefficient of variation for amygdalohippocampal volume was 6.9 ± 3.2% in DVA and 3.9 ± 2.0 in CAM. We also tested a more simplified method of assessing amygdalohippocampal volume by calculating the left to right volume ratio from MRI scans (2–40 films for each sample). Volume ratios determined directly from MRI films made in different months (14 samples) and of different sections (coronal and sagittal series, 18 samples) correlated well with each other (p < 0.01). Direct assessment of amygdalohippocampal volume can be used effectively for preoperative evaluation of the patient with epilepsy.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.