Abstract
Bilateral lesions in the substantia nigra were induced in rats trained in an instrumental learning program comparable with a fixed-interval schedule. General observations and examinations of rough motor behavior revealed rigidity, a decrease in spontaneous activity and a loss of postural reflexes. The analysis of lever-pressing rates results in a differentiation of rigidity and akinesia which is in accordance with the overt motor disturbances, dependent on the size of the nigral lesions.
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© 1975 S. Karger AG, Basel
1975
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