Introduction: Alopecia areata (AA) is an immune-mediated disease characterized by non-scaring hair loss. High levels of FABP4 have been implicated in different inflammatory diseases. We aim to assess and correlate the level of FABP4 in AA patients and compare with healthy controls. Methods: Eighty-Eight subjects enrolled subdivided equally into AA and healthy controls. AA patients were classified according to the severity and pattern of the disease. The concentration level of FABP4 in serum was assessed and compared to healthy controls using ELISA. Results: The level of FABP4 tends to increase in AA patients than controls with a significant difference (p = 0.0001).There were no statistically significant differences between FABP4 and gender, history, family history, related diseases, or prior treatments. There is a high significant difference between patients with relapse and progressive patients with p = 0.037. Also patients with positive effects in other body sites have higher FABP4 levels than patients without infection in other sites with p = 0.05. The level of FABP4 tends to increase with the severity of the patients. Findings show that there are positive correlations between FABP4 and (disease duration; number of attacks; SALT Score) with r = 0.45, p = 0.0021; r = 0.41, p = 0.007, and r = 0.88, p < 0.0001, respectively. Conclusion: Elevation of FABP4 in serum may correlate with disease severity and could play a vital role in the diagnosis of AA.

1.
Liu
Y
,
Li
J
,
Liang
G
,
Cheng
C
,
Li
Y
,
Wu
X
.
Association of alopecia areata with vitamin D and calcium levels: a systematic review and meta-analysis
.
Dermatol Ther
.
2020
;
10
(
5
):
967
83
.
2.
Mohamad
N
,
Khedr
AMB
,
Shaker
OG
,
Hassan
M
.
Expression of long noncoding RNA, HOTAIR, and MicroRNA-205 and their relation to transforming growth factor β1 in patients with alopecia areata
.
Skin Appendage Disord
.
2023
;
9
(
2
):
111
20
.
3.
Mao
H
,
Han
B
,
Li
H
,
Tao
Y
,
Wu
W
.
FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway
.
Mol Med Rep
.
2021
;
24
(
6
):
855
.
4.
Kagawa
Y
,
Low
YL
,
Pyun
J
,
Doglione
U
,
Short
JL
,
Pan
Y
, et al
.
Fatty acid-binding protein 4 is essential for the inflammatory and metabolic response of microglia to lipopolysaccharide
.
J Neuroimmune Pharmacol
.
2023
;
18
(
3
):
448
61
.
5.
Xiao
Y
,
Shu
L
,
Wu
X
,
Liu
Y
,
Cheong
LY
,
Liao
B
, et al
.
Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages
.
JCI insight
.
2021
;
6
(
7
):
e141814
.
6.
Guo
Z
,
Yang
Y
,
Liao
Y
,
Shi
Y
,
Zhang
LJ
.
Emerging roles of adipose tissue in the pathogenesis of psoriasis and atopic dermatitis in obesity
.
JID Innov
.
2022
;
2
(
1
):
100064
.
7.
Furuhashi
M
.
Fatty acid-binding protein 4 in cardiovascular and metabolic diseases
.
J Atheroscler Thromb
.
2019
;
26
(
3
):
216
32
.
8.
King
BA
,
Senna
MM
,
Ohyama
M
,
Tosti
A
,
Sinclair
RD
,
Ball
S
, et al
.
Defining severity in alopecia areata: current perspectives and a multidimensional framework
.
Dermatol Ther
.
2022
;
12
(
4
):
825
34
.
9.
Loh
SH
,
Moon
HN
,
Lew
BL
,
Sim
WY
.
Role of T helper 17 cells and T regulatory cells in alopecia areata: comparison of lesion and serum cytokine between controls and patients
.
J Eur Acad Dermatol Venereol
.
2018
;
32
(
6
):
1028
33
.
10.
Fukuyama
M
,
Ito
T
,
Ohyama
M
.
Alopecia areata: current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines
.
J Dermatol
.
2022
;
49
(
1
):
19
36
.
11.
Shaker
O
,
El-Tahlawi
S
,
Fawzy
M
.
Intestinal fatty acid bind protein as a biomarker for vitiligo
.
J Egypt Womens Dermatol Soc
.
2024
;
21
(
1
):
52
8
.
12.
Floresta
G
,
Pistarà
V
,
Amata
E
,
Dichiara
M
,
Marrazzo
A
,
Prezzavento
O
, et al
.
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review
.
Eur J Med Chem
.
2017
;
138
:
854
73
.
13.
Rodríguez-Calvo
R
,
Girona
J
,
Alegret
JM
,
Bosquet
A
,
Ibarretxe
D
,
Masana
L
.
Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease
.
J Endocrinol
.
2017
;
233
(
3
):
R173
84
.
14.
El-Taweel
,
A
,
Mustafa
,
A
,
Abd El-Halim
,
W
,
Abdel-Fattah
,
S
.
Serum fatty acid binding protein 4 in patients with androgenetic alopecia
.
Benha J Appl Sci
.
2020
;
5
(
Issue 5 part (2)
):
279
81
.
15.
Baran
A
,
Świderska
M
,
Bacharewicz-Szczerbicka
J
,
Myśliwiec
H
,
Flisiak
I
.
Serum fatty acid-binding protein 4 is increased in patients with psoriasis
.
Lipids
.
2017
;
52
(
1
):
51
60
.
16.
Sigurdardottir
G
,
Ekman
AK
,
Verma
D
,
Enerbäck
C
.
Decreased systemic levels of endocan-1 and CXCL16 in psoriasis are restored following narrowband UVB treatment
.
Dermatol
.
2018
;
234
(
5–6
):
173
9
.
17.
Stamu-O’Brien
C
,
Kroumpouzos
G
.
The role of lipids in vitiligo and schizophrenia
.
Clin Dermatol
.
2023
;
41
(
1
):
89
94
.
18.
Baran
A
,
Kiluk
P
,
Świderska
M
,
Maciaszek
M
,
Myśliwiec
H
,
Flisiak
I
.
Adipocyte fatty acid-binding protein as a novel marker of psoriasis and clinical response to acitretin
.
Lipids
.
2019
;
54
(
8
):
445
52
.
19.
Nowowiejska
J
,
Baran
A
,
Flisiak
I
.
Fatty acid-binding proteins in psoriasis-A review
.
Metabolites
.
2022
;
12
(
9
):
833
.
20.
Farag
AGA
,
Badr
EAE
,
El-Shafey
AES
,
Elshaib
ME
.
Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo
.
Bras Dermatol
.
2022
;
97
(
1
):
28
36
.
21.
Zhang
C
,
Li
T
,
Chiu
KY
,
Wen
C
,
Xu
A
,
Yan
CH
.
FABP4 as a biomarker for knee osteoarthritis
.
Biomark Med
.
2018
;
12
(
2
):
107
18
.
22.
Alshahrani
AA
,
Al-Tuwaijri
R
,
Abuoliat
ZA
,
Alyabsi
M
,
AlJasser
MI
,
Alkhodair
R
.
Prevalence and clinical characteristics of alopecia areata at a tertiary care center in Saudi Arabia
.
Dermatol Res Pract
.
2020
;
2020
:
7194270
.
23.
Eitan
LNA
,
Alghamdi
MA
,
Al Momani
RO
,
Aljamal
HA
,
Elsy
B
,
Mohammed
HM
, et al
.
Genetic association between interleukin genes and alopecia areata in Jordanian patients
.
Oman Med J
.
2022
;
37
(
5
):
e421
.
24.
Guttikonda
AS
,
Aruna
C
,
Ramamurthy
DV
,
Sridevi
K
,
Alagappan
SK
.
Evaluation of clinical significance of dermoscopy in alopecia areata
.
Indian J Dermatol
.
2016
;
61
(
6
):
628
33
.
25.
Abou-Taleb
DA
,
Abd El
H
,
Moubasher
AEA
.
Psychological impact of alopecia areata on Egyptian patients
.
J Clin Exp Dermatol Res
.
2021
;
12
:
568
.
26.
Fenske
DC
,
Ding
Y
,
Morrow
P
,
Smith
SG
,
Silver
MK
,
Moynihan
M
, et al
.
Comparing the burden of illness in patients with alopecia areata vs atopic dermatitis in the US population from a payer perspective
.
J Manag Care Spec Pharm
.
2023
;
29
(
4
):
409
19
.
27.
Mihara
M
,
Ohsugi
Y
,
Kishimoto
T
.
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis
.
Open Access Rheumatol
.
2011
;
3
:
19
29
.
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