Toe nail onychomycosis (ONM) is a common problem in elderly patients. Treatment in diabetic patients with associated comorbidities such as congestive heart failure becomes a challenge. Oral antifungals are best avoided owing to most of them being contraindicated or unsafe due to comorbidities and/or risk of drug interactions stemming from polypharmacy. Topical agents alone are not effective. Unlike isolated ONM in healthy and younger patients, ONM involving multiple nails in geriatric and diabetic patients warrants treatment as it serves as a source of recurrent tinea of the feet and other sites, and even contributes to formation of diabetic foot ulcers. Long-pulsed Nd:YAG and fractional CO2 laser (in addition to antifungals) have been reported to provide gratifying results in toe nail ONM. But high treatment cost is a major limitation. Nail peeling with glycolic acid (GA) and low-concentration croton-oil free phenol (CFP) peels have been used in different nail conditions but not specifically for ONM. We report the successful use of Black peel (a superficial-to-medium depth peel used typically for anti-acne and cosmetic indications), a combination of 50% black acetic acid, 0.5% salicylic acid, 6% tetrahydrojasmonic acid, 10% bio sulphur, and 0.1% potassium iodide, in two difficult cases with ONM of multiple nails, the rationale of use being the additional anti-fungal effects of all the peel components.

1.
Gupta
AK
,
Carviel
J
,
Shear
NH
.
Antibiofilm Treatment for Onychomycosis and Chronic Fungal Infections
.
Skin Appendage Disord
.
2018
Aug
;
4
(
3
):
136
40
.
[PubMed]
2296-9195
2.
Alberdi
E
,
Gómez
C
.
Efficiency of methylene blue-mediated photodynamic therapy vs intense pulsed light in the treatment of onychomycosis in the toenails
.
Photodermatol Photoimmunol Photomed
.
2018
Aug
;
•••
: ;
Epub ahead of print
.
[PubMed]
0905-4383
3.
Houang
J
,
Perrone
G
,
Mawad
D
,
Boughton
PC
,
Ruys
AJ
,
Lauto
A
.
Light treatments of nail fungal infections
.
J Biophotonics
.
2018
Mar
;
11
(
3
):
e201700350
.
[PubMed]
1864-063X
4.
Zalacain
A
,
Merlos
A
,
Planell
E
,
Cantadori
EG
,
Vinuesa
T
,
Viñas
M
.
Clinical laser treatment of toenail onychomycoses
.
Lasers Med Sci
.
2018
May
;
33
(
4
):
927
33
.
[PubMed]
0268-8921
5.
Banga
G
,
Patel
K
.
Glycolic Acid peels for nail rejuvenation
.
J Cutan Aesthet Surg
.
2014
Oct-Dec
;
7
(
4
):
198
201
.
[PubMed]
0974-2077
6.
Daulatabad
D
,
Nanda
S
,
Grover
C
.
Intra-individual Right-left Comparative Study of Medium Depth Peels in Superficial Nail Abnormalities
.
J Cutan Aesthet Surg
.
2017
Jan-Mar
;
10
(
1
):
28
32
.
[PubMed]
0974-2077
7.
de Castro
RD
,
Mota
AC
,
de Oliveira Lima
E
,
Batista
AU
,
de Araújo Oliveira
J
,
Cavalcanti
AL
.
Use of alcohol vinegar in the inhibition of Candida spp. and its effect on the physical properties of acrylic resins
.
BMC Oral Health
.
2015
Apr
;
15
(
1
):
52
.
[PubMed]
1472-6831
8.
Bjarnsholt
T
,
Alhede
M
,
Jensen
,
Nielsen
AK
,
Johansen
HK
,
Homøe
P
, et al.
Antibiofilm Properties of Acetic Acid
.
Adv Wound Care (New Rochelle)
.
2015
Jul
;
4
(
7
):
363
72
.
[PubMed]
2162-1918
9.
Arif
T
.
Salicylic acid as a peeling agent: a comprehensive review
.
Clin Cosmet Investig Dermatol
.
2015
Aug
;
8
:
455
61
.
[PubMed]
1178-7015
10.
Alem
MA
,
Douglas
LJ
.
Effects of aspirin and other nonsteroidal anti-inflammatory drugs on biofilms and planktonic cells of Candida albicans
.
Antimicrob Agents Chemother
.
2004
Jan
;
48
(
1
):
41
7
.
[PubMed]
0066-4804
11.
Martínez
JA
. Natural Fungicides Obtained from Plants, Fungicides for Plant and Animal Diseases. In:
Dhanasekaran
D
, editor
.
Fungicides for Plant and Animal Diseases
. 1st ed.
Rijeka, Croatia
:
InTech
;
2012
. pp.
1
28
. ISBN: 978-953-307-804-5, Available from http://www.intechopen.com/books/fungicides-for-plant-and-animal-diseases/natural-fungicides-obtained-fromplants
12.
Droby
S
,
Porat
RE
,
Weiss
B
,
Shapiro
B
,
Philosoph-Hadas
S
,
Meir
S
.
Suppressing green mold decay in grapefruit with postharvest jasmonate application
.
J Am Soc Hortic Sci
.
1999
;
124
(
2
):
184
8
.0003-1062
13.
Greene
SL
,
Huang
YE
,
Huang
LD
,
Weart
IF
,
Yang
SA
,
Malik
S
, et al.
(
2011
).
Antimicrobial Compositions Comprising a Jasmonic Acid Compound as Active Agent.
European Patent No. EP 1845964B1. Paris, France.: European Patent Office.
14.
Gupta
AK
,
Nicol
K
.
The use of sulfur in dermatology
.
J Drugs Dermatol
.
2004
Jul-Aug
;
3
(
4
):
427
31
.
[PubMed]
1545-9616
15.
Hamidizadeh
N
,
Simaeetabar
S
,
Handjani
F
,
Ranjbar
S
,
Moghadam
MG
,
Parvizi
MM
.
Composition of minerals and trace elements at Mamasani thermal source: A possible preventive treatment for some skin diseases
.
J Educ Health Promot
.
2017
Dec
;
6
(
1
):
110
.
[PubMed]
2277-9531
16.
Costa
RO
,
Macedo
PM
,
Carvalhal
A
,
Bernardes-Engemann
AR
.
Use of potassium iodide in dermatology: updates on an old drug
.
An Bras Dermatol
.
2013
May-Jun
;
88
(
3
):
396
402
.
[PubMed]
0365-0596
17.
Mahajan
VK
.
Sporotrichosis: an overview and therapeutic options
.
Dermatol Res Pract
.
2014
;
2014
:
272376
.
[PubMed]
1687-6105
18.
Masood
R
,
Wrobel
B
,
Dale
H
.
A Comparison of the Effectiveness of Tincture of Iodine and potassium Iodide on Chronic Sinusitis Patients with Biofilm
.
J Neurol Neurosurg
.
2017
;
6
(
3
):
555690
.2373-8995
19.
Wen
X
,
Zhang
X
,
Szewczyk
G
,
El-Hussein
A
,
Huang
YY
,
Sarna
T
, et al.
Potassium Iodide Potentiates Antimicrobial Photodynamic Inactivation Mediated by Rose Bengal in In Vitro and In Vivo Studies
.
Antimicrob Agents Chemother
.
2017
Jun
;
61
(
7
):
e00467
17
.
[PubMed]
0066-4804
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