Abstract
Onychomatricoma is a rare and specific benign tumor of the nail complex, with uncertain etiology. The avulsion of the nail plate reveals cavitations and orifices in its proximal extremity. These are associated with villous tumor formations generating digitiform projections at the nail matrix – typical intraoperative findings. We report a rare case of onychomatricoma in which the nail bed was predominantly affected and show evidence of its clinical, intraoperative, and histopathological presentation. The various descriptions of the disease report that its origin is restricted to the nail matrix, leading to secondary changes in the nail plate.
References
1.
Baran
R
, Kint
A
. Onychomatrixoma. Filamentous tufted tumour in the matrix of a funnel-shaped nail: a new entity (report of three cases)
. Br J Dermatol
. 1992
May
;126
(5
):510
–5
.
[PubMed]
0007-09632.
Tavares
GT
, Di Chiacchio
N
, Di Chiacchio
NG
, Souza
MV
. Onicomatricoma: um tumor desconhecido pelo dermatologista
. An Bras Dermatol
. 2015
;90
(2
):268
–70
.
[PubMed]
0365-05963.
Perrin
C
, Baran
R
, Balaguer
T
, Chignon-Sicard
B
, Cannata
GE
, Petrella
T
, et al. Onychomatricoma: new clinical and histological features. A review of 19 tumors
. Am J Dermatopathol
. 2010
Feb
;32
(1
):1
–8
.
[PubMed]
0193-10914.
Fayol
J
, Baran
R
, Perrin
C
, Labrousse
F
. Onychomatricoma with misleading features
. Acta Derm Venereol
. 2000
Sep-Oct
;80
(5
):370
–2
.
[PubMed]
0001-55555.
Di Chiacchio
N
, Tavares
GT
, Tosti
A
, Di Chiacchio
NG
, Di Santis
E
, Alvarenga
L
, et al. Onychomatricoma: epidemiological and clinical findings in a large series of 30 cases
. Br J Dermatol
. 2015
Nov
;173
(5
):1305
–7
.
[PubMed]
0007-09636.
Perrin
C
, Baran
R
. Onychomatricoma with dorsal pterygium: pathogenic mechanisms in 3 cases
. J Am Acad Dermatol
. 2008
Dec
;59
(6
):990
–4
.
[PubMed]
0190-96227.
Stewart
CL
, Sobanko
JF
, Rubin
AI
. Myxoid onychomatricoma: an unusual variant of a rare nail unit tumor
. Am J Dermatopathol
. 2015
Jun
;37
(6
):473
–6
.
[PubMed]
0193-10918.
Regalo
G
, Leutz
A
. Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia
. EMBO Mol Med
. 2013
Aug
;5
(8
):1154
–64
.
[PubMed]
1757-46769.
Perrin
C
, Langbein
L
, Schweizer
J
. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed
. Br J Dermatol
. 2004
Aug
;151
(2
):362
–71
.
[PubMed]
0007-096310.
Perrin
C
. Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit
. Am J Dermatopathol
. 2007
Dec
;29
(6
):543
–50
.
[PubMed]
0193-109111.
Wang
L
, Gao
T
, Wang
G
. Nail bed onychomatricoma
. J Cutan Pathol
. 2014
Oct
;41
(10
):783
–6
.
[PubMed]
0303-6987© 2018 S. Karger AG, Basel
2018
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