In conscious rats inhibition of kallikrein formation with aprotinin suppressed urinary prostaglandin (PG) E2 excretion. This was associated with a decrease in inner cortical perfusion in the absence of changes in GFR or hippuran clearance. During acute expansion of the extracellular fluid volume (ECFV) with isotonic saline PGE2 excretion significantly increased but was suppressed during stable ECFV expansion. With ECFV expansion GFR increased, while total and regional cortical perfusion remained unchanged. Aprotinin suppressed the early rise in PGE2 excretion and reduced GFR and hippuran clearance as a result of decreased outer cortical perfusion. It is suggested that integrity of the kinin-prostaglandin system represents an important prerequisite for the functional adaptation of the kidney to acute expansion of the ECFV with isotonic saline.

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