... in a rheumatologic unit (RU). Methods: Patients with RA, systemic sclerosis (SSc), primary Sjӧgren’s syndrome (pSS), and idiopathic inflammatory myopathy were retrospectively enrolled from an RU and a PU designated to manage ILD during a period from January 2017 to October 2022. The classification of CTD-PU...

... Rheumatoid arthritis Systemic lupus erythematosus Systemic sclerosis Dermatomyositis-polymyositis Primary Sjögren’s syndrome Mixed connective tissue disease Ankylosing spondylitis Subacute-acute, hyperacute, or even catastrophic and fulminant respiratory events occur in the ambit of almost all...

...Afroditi K. Boutou; Georgia G. Pitsiou; Panagiota Siakka; Theodoros Dimitroulas; Asimina Paspala; Evdokia Sourla; Nikolaos Chavouzis; Alexandros Garyfallos; Paraskevi Argyropoulou; Ioannis Stanopoulos Background: Exercise impairment is a common symptom of systemic sclerosis (SSc), a disorder which...

... necrosis surrounded by chronic inflammatory cells and fibrosis. Rheumatoid arthritis Systemic lupus erythematosus Systemic sclerosis Dermatomyositis-polymyositis Primary Sjögrenߣs syndrome Mixed connective tissue disease Ankylosing spondylitis Pleuritis Fibrotic nonspecific interstitial...

...Navneet Singh; Karan Madan; Anish Bhattacharya; Raje Nijhawan Malignant pleural mesothelioma (MPM) is a relatively rare but aggressive pleural tumor. Systemic sclerosis (SSc) is associated with the development of lung cancer and other malignancies. We describe a 58-year-old never-smoker female...

...Julien Pernot; Eve Puzenat; Nadine Magy-Bertrand; Philippe Manzoni; Anne Gondouin; Hubert Bourdin; Marie-Laure Simon-Rigaud; Jacques Regnard; Bruno Degano Background: Interstitial lung disease (ILD) is a leading cause of death in systemic sclerosis (SSc). Sensitivities and specificities...

...Xaver Baur; Hans-Peter Rihs; Peter Altmeyer; Paul Degens; Karsten Conrad; Jürgen Mehlhorn; Karin Weber; Volker Wiebe Systemic sclerosis (scleroderma) is a connective tissue disease with a wide range of clinical manifestations, with high or low degrees of skin and internal organ involvement together...

...Jürgen Behr; Bernhard C. Adelmann-Grill; Rüdiger Hein; Thomas Beinert; Martin Schwaiblmair; Fritz Krombach; Günter Fruhmann Fibrosing alveolitis (FA) is a major and often fatal complication of systemic sclerosis (SSC). The critical role of fibroblasts in the pathogenesis of FA has long been...

...Keiji Yoshioka We report a case of systemic sclerosis (SSc) associated with mediastinal lymphadenopathy. A 77-year-old woman was admitted because of general fatigue. Mediastinal lymphadenopathy was diagnosed by chest computed tomography before the skin and lung involvements of SSc was discovered...

...Riccardo Pistelli; Carlo Ludovico Maini; Leonello Fuso; Rodolfo Muzzolon; Massimo Giuliano Bonetti; Raffaele Antonelli Incalzi; Alessandro Giordano; Salvatore Paoletti In an attempt to define the early features and the natural evolution of lung involvement in progressive systemic sclerosis (PSS...

... cellular and soluble materials from lung airways. Objective: To evaluate if IS may be a useful and safe tool for the detection of airway inflammation in patients with interstitial lung disease (ILD) in systemic sclerosis (SSc). Methods: Sixty-eight patients with SSc and ILD as well as 18 healthy...

.... Objectives: To determine clinical, radiological and histopathological features of systemic sclerosis (SSc) patients according the presence or absence of centrilobular fibrosis (CLF). Methods: Twenty-eight SSc patients with lung involvement were submitted to open lung biopsy and the specimens classified...

...Erika Franco de Carvalho; Edwin Roger Parra; Romy de Souza; Alexandre Muxfeldt A’b Saber; Vera Luiza Capelozzi Background: Interstitial lung disease is a well-recognized prognostic factor in systemic sclerosis (SSc). As the prognosis in nonspecific interstitial pneumonia (NSIP) has been described...

...Elena Bargagli; Mauro Galeazzi; Francesca Bellisai; Luca Volterrani; Paola Rottoli This is the first report of the efficacy of anti-TNFα treatment in a patient with lung fibrosis and pulmonary hypertension associated with advanced systemic sclerosis, refractory to conventional therapies...