... transbronchial needle aspiration (TBNA) offers a higher diagnostic yield than the 22-G needle in sarcoidosis. No randomized trial has compared the yield of the two needles. Methods: We randomized consecutive subjects with suspected sarcoidosis and enlarged thoracic lymph nodes to undergo EBUS-TBNA with either...

...Katharina Buschulte; Philipp Höger; Claudia Ganter; Marlies Wijsenbeek; Nicolas Kahn; Katharina Kriegsmann; Finn Moritz Wilkens; Markus Polke; Sarah El-Hadi; Christoph Lederer; Felix J. Herth; Michael Kreuter Background: Sarcoidosis is a multisystemic disease with a heterogenous course of disease...

...Ada E.M. Bloem; Rémy L.M. Mostard; Naomi Stoot; Jan W.H. Custers; Martijn Vooijs; Daisy J.A. Janssen; Alex J. van ‘t Hul; Martijn A. Spruit Background: Self-management is considered important in the management of patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis. However, data about...

...Elad Guber; Ori Wand; Gali Epstein Shochet; Ayal Romem; David Shitrit Background: Sarcoidosis is a heterogeneous multisystemic disorder of unknown etiology. Dyspnea and fatigue are two of the most common and debilitating symptoms experienced by subjects with sarcoidosis. There is limited evidence...

...Anita Grongstad; Martijn A. Spruit; Line Merethe Oldervoll; Nina Køpke Vøllestad; Anne Edvardsen Background: There is limited evidence regarding the impact of multidisciplinary pulmonary rehabilitation (PR) on exercise capacity and fatigue in patients with pulmonary sarcoidosis. The aim...

...Paolo Cameli; Stefano Gonnelli; Elena Bargagli; Miriana d’Alessandro; Laura Bergantini; Valentina Favetta; Maria Dea Tomai Pitinca; Edoardo Lisi; Rosa Metella Refini; Maria Pieroni; Piersante Sestini; Carla Caffarelli Background: Calcium metabolism alterations are quite common in sarcoidosis...

...Mareye Voortman; Celine M.R. Hendriks; Paul Lodder; Marjolein Drent; Jolanda De Vries Background: Consequences of sarcoidosis are wide ranging, and the symptom burden has a great impact on patients’ quality of life (QoL). However, the QoL of couples living with sarcoidosis has not yet been studied...

.... Endobronchial ultrasound Lymphadenopathy Lung cancer Rapid on-site evaluation Sarcoidosis Rapid on-site evaluation (ROSE) is perceived by most interventional pulmonologists and pathologists as a useful adjunct to endosonography (endobronchial ultrasound, EBUS; endoscopic ultrasound with a regular...

...Heidrun Lingner; Heike Buhr-Schinner; Stefan Hummel; Jochen van der Meyden; Anika Grosshennig; Daniel Nowik; Konrad Schultz Background: Real-world data on the effects of a multicomponent pulmonary rehabilitation (PR) for patients with sarcoidosis are scarce. Objective: To describe characteristics...

... for pathological confirmation of sarcoidosis, it is unclear how many passes are required to obtain diagnostic materials. Objectives: The aim of this study was to determine the number of needle passes needed for the diagnosis of stage I/II sarcoidosis using EBUS-TBNA. Methods: At three institutions, 109 patients...

...Thomas Bahmer; Henrik Watz; Maria Develaska; Benjamin Waschki; Klaus F. Rabe; Helgo Magnussen; Detlef Kirsten; Anne-Marie Kirsten Background: Little is known about physical activity in daily life among patients with sarcoidosis. Fatigue is a frequent and disabling symptom that might negatively...

... a concurrent or preexisting non-pulmonary malignancy. The overall yield of EBUS-TBNA for specific diagnosis was 300/350 (86%). The diagnostic yield for sarcoidosis, lymphoproliferative disease, metastatic lymphadenopathy from extrathoracic malignancy, and necrotizing granuloma was 123/149 (83%), 27/33 (82...

...Nissim Arish; Rottem Kuint; Eli Sapir; Liran Levy; Avraham Abutbul; Zvi Fridlender; Uri Laxer; Neville Berkman Background: The association between sarcoidosis and malignancy is poorly defined. Sarcoidosis can precede, be diagnosed concurrently with, or follow malignancy. Objectives: We describe...

... (TB) is responsible for the largest number of cases, while necrotizing sarcoidosis is generally considered a rare and easily distinguishable disease substantially based on histological features. However, this entity has become a viable diagnosis in the absence of mycobacteria isolation or when...

...Andrea Bosse-Henck; Rainer Koch; Hubert Wirtz; Andreas Hinz Background: Fatigue is common among patients with sarcoidosis. The etiology of this problem is unknown and multifactorial. Fatigue can be confounded with excessive daytime sleepiness (EDS). Fatigue and sleepiness have rarely been studied...

...+ lymphocytes in pulmonary sarcoidosis originate from redistribution from the peripheral blood to the lung, and therefore do not bear the CD103 integrin. Some data suggest that a low CD103+ percentage among bronchoalveolar lavage fluid (BALF) CD4+ lymphocytes discriminates between sarcoidosis and other...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pulmonary rehabilitation program Sarcoidosis We read with great interest the paper by Holland et al. [ 1...

...Anne-Kathrin Brill; Sebastian R. Ott; Thomas Geiser Mycophenolate Bronchiectasis Sarcoidosis Hypogammaglobulinaemia We thank Dr. Medford for his valuable and interesting comments [ 1 ] on our recent article in Respiration on mycophenolate mofetil (MMF) in the treatment of chronic...

...Andrew R.L. Medford Brill et al. [ 1 ] report on the potential utility of mycophenolate mofetil (MMF) as a steroid-sparing agent in chronic pulmonary sarcoidosis in 10 patients with some success in the reduction of systemic steroids while preserving lung function and clinical stability. Although...

...M.B. von Bartheld; A. van Breda; J.T. Annema Background: Endosonography [endoscopic ultrasound (EUS)-guided fine needle aspiration and endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration] is increasingly used for lung cancer staging and the assessment of sarcoidosis. Serious...