... understanding of the changes in respiratory mechanics that occur after the application of a bronchodilator. Objectives: We aimed to (1) assess the response to salbutamol and to compare the impedance changes in healthy individuals and COPD patients, (2) investigate the effects of airway obstruction...

...F. Montalvo; O. Cantres-Fonseca; G. Santos; M. Vega; I. Torres; J. Carmona; D. Dexter; G. Santacana Background: The involvement of the airway smooth muscle mediator nitric oxide (NO) in the actions of the β 2 agonist salbutamol (Sal), a well- known bronchodilator, is very poorly understood...

...M. Malerba; E. Boni; C. Tantucci; B. Filippi; G. Romagnoni; V. Grassi The effects on exercise tolerance after acute administration of β 2 -agonists were investigated in 11 patients with partly reversible chronic airway obstruction after 400 μg of salbutamol (S) given intravenously (i.v.) and after...

...François Philip-Joet; Marline Reynaud-Gaubert; Jean-Luc Jirou-Najou; Alain Arnaud A 2-month study was carried out to compare the efficacy and safety of Berodual® (B) (Boehringer Ingelheim) and salbutamol (S) in asthma. B is a combined agent with 20 µg of ipratropium bromide and 50 µg of fenoterol...

...M.M. Nieminen; M. Vidgren; K. Laurikainen; M. Järvinen; K. Liippo; R. Tammivaara; M. Silvasti Twenty-one adult asthmatic patients participated in a trial to compare the clinical equivalence of a single dose of salbutamol inhaled either from a novel multiple dose powder inhaler (MDPI), Easyhaler®...

... litre) with continuous ambulatory cardiac monitoring. Patients received either nebulised salbutamol (5 mg) or saline each given 4 times daily for 24 h on 2 consecutive days, single blind, in random order. Supraventricular arrhythmias were common on both saline and salbutamol days (8 vs. 9 patients, p...

...M. Ferrari; R. Testi; D. Romito; S. Adami; M. Olivieri; L. Squassante; M. Prior; V. Lo Cascio Twelve asthmatic patients received by inhalation for 2 weeks, in a double-blind, cross-over design, beclomethasone dipropionate (BDP; 600 μg/day) plus salbutamol (S; 900 μg/day), or S (900 μg/day) alone...

.../0.04 mg), salbutamol (S; 0.2 mg) and placebo (P) were given by metered-dose inhaler at the same time of the day on three different occasions. FEV 1 and specific airway resistance (sRaw) were assessed before and at specific intervals following inhalation. The results showed that F/IB and S produced...

...B. Violante; R. Pellegrino; C. Vinay; R. Selleri; G. Ghinamo We investigated the effects of intravenously administered aminophylline (A; 6 mg/kg over 20 min, followed by 0.9 mg/kg/h), salbutamol (S; 4 µg/kg over 20 min, followed by 3 µg/kg/h) and placebo (P; saline solution) on the strength...

... COAD before and after placebo or salbutamol. There was a significant improvement of the distribution of ventilation to the lung bases after salbutamol (p < 0.05) 4 08 1987 5 07 1988 20 1 2009 © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright...

...G. Carpentiere; S. Marino; F. Castello; C.T. Bonanno; C. Baldanza Twelve subjects with stable asthma each inhaled two puffs (200 μg) of salbutamol on 2 separate days 3 h after double-blind oral administration of ketotifen (two 1-mg capsules) or identical placebo. FEV 1 was recorded before...

...D. Patakas; E. Maniki; V. Tsara; E. Daskalopoulou We studied 18 asthmatic patients over an 8-week period. Each patient received for 4 weeks continuous and for 4 weeks intermittent salbutamol rotacaps (400 μg) using a double-crossover technique. No significant differences were found between the two...

...Roger J. Wolstenholme; S.P. Shettar In a randomized, double-blind, double-dummy, crossover study consisting of two 1-month periods with a 2-week ‘run-in’ we compared the effects of a combination of fenoterol with ipratropium bromide (Duovent®, Boehringer Ingelheim) and salbutamol administered...

...C.-G. Löfdahl; A. Sigvaldasson; B.-E. Skoogh; N. Svedmyr Two double-blind, double-dummy, randomized, crossover studies were performed in 8 asthmatic patients to evaluate β 2 -adrenoceptor selectivity and potency of broxaterol compared to salbutamol. By oral route, a study with cumulatively...

... -adrenergic stimulation with salbutamol were compared in 11 asthmatic and 11 non-asthmatic subjects. There was no consistent difference between the two groups in the plasma free fatty acid, glucose and potassium responses, or in the cardiovascular variables studied, but the asthmatic patients demonstrated...

...A.R.A. Sovijärvi; K. Reinikainen; Y. Freudenthal; P. Andersson; H. Riska The preventive effects of inhaled formoterol (a new β 2 -agonist) and salbutamol aerosols on histamine-induced bronchoconstriction were studied in 12 patients with mild or moderate asthma in a placebo-controlled, double-blind...

...G.M. Pover; G. Greger; P. Kaspar The effect of the simultaneous administration of salbutamol and beclomethasone dipropionate, from a combination inhaler, was compared with the same doses given with an interval of 10 min, from separate inhalers, in a group of 40 asthmatic females. The double-blind...

...M. Molho; S. Benzaray; M. Lidji; A. Karasik; S. Steir; G.L. Baum The site of bronchodilatation produced by inhaled salbutamol (0.045 mg/ kg) versus atropine (0.035 mg/kg) was investigated in 14 asthmatic young patients. No significant difference was found between the effects of the drugs on any...

... cells from guinea pig tracheas. Ambroxol significantly stimulated the CBF up to 10.8%, salbutamol up to 19.5%. The effect of ambroxol on CBF certainly contributes to, but does not explain the more pronounced increase in transport rate. Thus a stimulation of the mucociliary transport rate by the other...

...E. Marangio; A. Pesci; A. Mori; M. Marchioni; G. Bertorelli We studied the bronchodilator effect of a combination of fenoterol (100 µg) and ipratropium bromide (40 µg) (Duovent) versus salbutamol and placebo in 16 patients with chronic obstructive lung disease (COLD). FEV 1 and the side-effects...