...Arturo Genovese; Massimo Chiariello; Salvatore Latte; Walter De Alfieri; Mario Condorelli Development of bilateral ventricular hypertrophy in animals exposed to sustained hypoxia is demonstrated. Female Sprague-Dawley rats (180–200 g) were subjected to acute (0.40 atm/24 h) or chronic intermittent...

...J.M. Kay; P.M. Keane; K.L. Suyama We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p -chlorophenylalanine (PCPA) which inhibits 5-HT synthesis. We measured right ventricular mean systolic pressure...

...J. Ressl; D. Urbanová; J. Widimský; B. Oštádal; V. Pelouch; J. Procházka The effect of intermittent altitude hy- poxia simulated in a hypobaric chamber (7,000 m, 8 h daily, 5 days a week) on the lesser circulation and heart weight was studied in rats. A marked chronic pulmonary hypertension...

... in bronchiolar obliteration and serve as basis for experimental therapeutic research. Objectives: In this study, we adapted the nitric acid (NA) technique to develop a suitable model to study CBO in rats. Methods: We have intratracheally instilled 0.5% NA or saline and studied the histological lesions on days 2...

...-A-pretreated rats. Twenty-nine rats (8 controls, 10 ovalbumin sensitized, and 11 Cyc-A inhaling and ovalbumin sensitized) were included in the study. A commercial intravenous Cyc-A solution was given as a single dose of 20 mg/kg 1 h prior to inhalation of ovalbumin via nebulizer. The total number of BAL cells...