... for analysis for either missing 12 months of follow-up or baseline pulmonary function. Results: Among the 123 AATD patients, 27 (22.0%) had at least one exacerbation in the last 12 months of follow-up. Patients with Pi*ZZ phenotype were three times more likely than the rest of the population to experience any...

...- and adult-onset asthma, no differences were found as concerns blood and sputum eosinophils (online suppl. Table 3S). Asthma Airway inflammation Phenotype Granulocytic pattern Airway inflammation is a characteristic usually present in patients with asthma [1]. Eosinophils are the granulocytic...

...: Stratifying patients by F E NO level can identify specific asthma phenotypes with distinct clinical features and predictors useful in clinical practice to tailor treatment and improve asthmatic patients’ outcomes. [email protected] 23 08 2021 29 03 2022 5 5 2022...

... with severe asthma and bronchiectasis present with distinct characteristics resulting in different treatable traits. In addition, we explored whether bronchiectasis in severe asthma is more common in a specific phenotype. Methods: This is a single-center study consecutively including patients with severe...

...Min Xie; Xian-Sheng Liu; Yong-Jian Xu; Zhen-Xiang Zhang; Jing Bai; Wang Ni; Shi-Xin Chen Background: It has been demonstrated that the phenotypic modulation of airway smooth muscle cells (ASMCs) is important to the pathogenesis of airway remodeling in chronic asthma. The extracellular signal...