...Christian Schulz; Benjamin Stoelcker; Brigitte Ruhland; Nico Jentsch; Andreas Steege Background: Neutrophilic airway inflammation is one of the key features of chronic obstructive pulmonary disease (COPD). The chemokine receptors 1 (CXCR1) and 2 (CXCR2) are expressed in the bronchial mucosa during...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Copy number variation Fc receptors Gene dosage Idiopathic pulmonary fibrosis Neutrophils Recent studies on the characterisation of copy number variation (CNV...

...-blind trial of erythromycin for a period of 6 months. Thirty-six COPD patients were randomized to treatment with oral erythromycin (125 mg, three times/day) or placebo. The primary outcomes were neutrophil number in sputum and exacerbations. Results: Thirty-one patients completed the study. At the end...

... , NO, CO, and O 3 produced during the SIC did not exceed threshold limit values. Samples of induced sputum were obtained before and after the SIC and showed an increase in neutrophils and concentrations of IL-8, TNF-α and TNF-β after the SIC. This study presents the first clinical findings reported...

... Neutrophils fesprafcn Original Paper Respiration 1997:64:23-28 Received: August 25, 1995 Accepted after revision: June 20. 1996 Adrian Gillissen8 Doris Wickenburga Dominique van Z w ollh Gerhard Schultze- Werninghausa Division o f Pncumology. Allergology and Sleep Medicine. Department o f Internal Medicine...

... in bronchoalveolar lavage fluid. When the dogs were given the saline placebo, ozone induced a marked increase in airway responsiveness to acetylcholine and a marked influx of neutrophils in the airways. When the dogs were given ambroxol, ozone induced the same increase in the number of neutrophils in bronchoalveolar...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Host Microbe Respiratory infection Cilia Neutrophils Respiration I989:55(suppl 1):5 8 © 1989 S. Ktirger A Basel (X)14-312X/89/0557-0005 S 2.75 '0 Host-Microbe Relationships...

...Patricia S. Mikes; Lydia L. Polomski; Michele R. De Musis; Bernard L. Gee We describe some features of neutrophil migration and their defense or injury mechanism in the lung. Employing an intratracheal silica instillation model in rats, we examined the effects on the silica-induced neutrophil...

...Franco Dallegri; Luciano Ottonello; Patrizia Dapino; Maurizio Bevilacqua When neutrophils are recruited to tissue sites and exposed to phagocytosable targets, they release oxidants which may be responsible for the local inactivation of alpha-1-proteinase inhibitor (AlPI). Consequently, AlPI becomes...

..., b Institute of Respiratory Diseases, University of Pavia; Scharper Clinical Research Department, Milan. Italy Key Words. RU 41740 Neutrophils Monocytes Clinical efficacy Chronic bronchitis Abstract. A double-blind trial was performed to investigate the effects of RU 41740, a glycoprotein...

...L. Ottonello; P. Dapino; E. Dallegri Supernatants, obtained from normal neutrophil polymorphonuclear leukocytes (PMN), challenged with opsonized zymosan (OPZ), were found to inactivate the PMN elastase inhibitor, α 1 -proteinase inhibitor (A1PI). As the supernatants were treated with methionine...

...D. Behera; S. Dash; S. Sen Myeloperoxidase (MPO) level and MPO scoring were estimated in Indian bidi smokers and compared with those in cigarette smokers and non-smokers. The values were higher in the neutrophils of 20 bidi smokers compared to 20 age-matched non-smokers (p < 0.001). However...

...Patrizia Dapino; Luciano Ottonello; Franco Dallegri Neutrophil migration through the microvascular endothelium represents a fundamental event for the cell accumulation at sites of tissue injury. Owing to their capacity to modify the structural and functional characteristics of endothelial cells...

... of many functional properties of both neutrophils and monocytes were demonstrated. The percentage of patients with intermediate (between 1 and 2 SD below the mean of controls) and defective (lower than 1.96 SD) values of chemotaxis, phagocytosis index and Candida killing was about 50%. Phagocytosis...

...A. Lurie; D. Theven; M.B. Brun-Pascaud; M. Fay; J.J. Pocidalo In order to study the role of neutrophils in hyperoxic lung edema, we induced a sustained granulocytopenia in rats by giving them a single intraperitoneal injection of 50 mg · kg”1 cyclophosphamide (CY) (CY-injected rats). Hyperoxic lung...

... Neutrophils Oxygen radicals Lung injury Iron chelators Lipid peroxidation Respiration 50: suppl. 1, pp. 5-12 (1986) © 1986 S. Karger AG. Basel 0025-7931 /86/0507-0005 $ 2.75/0 Animal Models of Oxidant Lung Injury Peter A. Ward, Kent J. Johnson, Gerd O. TUI Department of Pathology, Medical Center...

..., sputum induction was done. Results: Oral glucorticosteroids did not prevent pulmonary function decrement due to O 3 . After placebo, the percentage of neutrophils in induced sputum was significantly higher after O 3 than after air [52.1 (15.7–77.3) vs. 17.8 (1.7–58.4), p = 0.02, O 3 vs. air...

... receptor antagonist, at the recommended therapeutic dose affects neutrophil functions which are essential for host defense. Methods: Twenty nonsmoking patients between the ages of 18 and 70 with moderate asthma were recruited to the study. All of them were receiving inhaled corticosteroids for at least 6...

...K.M. Beeh; J. Beier; M. Ernst; O. Kornmann; R. Buhl Background: Neutrophilic inflammation is a major feature of chronic obstructive pulmonary disease (COPD), and several novel therapies aim at the suppression of neutrophils in COPD. Due to the abundance and redundancy of mediators involved...

... spontaneous or induced sputum cultures were evaluated on entry into the study, after a 2 months of treatment and following the 6-week washout period. Results: After the 2-month FP treatment, no significant changes in the number of peripheral blood neutrophils, blood gas and spirometry data were observed...