... of these proliferative cells is still undetermined. Objective: The aim of this study was to examine whether bone marrow (BM)-derived adult stem cells are responsible for the proliferative cells in asthmatic airway remodeling. Methods: Adult mice were durably engrafted with BM isolated from green fluorescent protein (GFP...

...C. Popow; R. Mallinger; P. Böck; J. Häusler; G. Lubec Structural and functional changes in lung tissue of mice fed with β-amino-propionitrile fumarate, L -3- cis -hydroxyproline, and L -4- cis -hydroxyproline. We fed 0.1% solutions of 3- cis -hydroxyproline (3cisHP), 4- cis -hydroxyproline (4cisHP...

... alveolar formation. Objective: A study was conducted to determine whether ATRA can induce new alveolar septa and reverse the airspace enlargement caused in adult mice by PPE treatment. Methods: 48 FVB mice were divided into 6 groups. Three groups received 15 µg of PPE in 0.1 ml of 0.9% saline and 3 groups...

...N. Berkman; S. Kremer; R. Or; I.S. Lossos; T.G. Christensen; R.H. Goldstein; R. Breuer Background: Bleomycin (Bleo)-induced lung injury in mice serves as an animal model of pulmonary fibrosis. The pathogenesis of pulmonary fibrosis remains unclear, but it comprises both inflammatory and fibrotic...

... hyperreactivity in mice induced by ovalbumin (OA) inhalation challenge in comparison with an invasive method. Enhanced pause (P enh ) was used as an index of airway obstruction. Methods: Eight mice were sensitized by OA (group I) and then challenged with OA. Twenty-four hours later, pulmonary function testing...

... injury, by testing the effect of two known Th1 inhibitors: linomide and pentoxifylline. Methods: C57BL/6 mice were treated by a single intratracheal instillation of 0.06 mg bleomycin in 0.01 ml saline or saline alone. Treatment groups included: (1) intratracheal bleomycin and daily treatment...