...) and a methacholine challenge test (MCT). Methods: A total of 26 asthmatics and 29 healthy controls were included. Forced expiratory volume in 1 s (FEV 1 ), EBT and oral, axillary and auricular temperatures were measured before and after EVH and MCT. Results: FEV 1 % predicted (%p) was significantly lower...

...W. Marek; W.T. Ulmer The interaction of vagal neuronal and pharmacological mediator mechanisms on the airway-constrictory responses obtained from challenges with aerosolized methacholine (MCH) before and after bilateral vagotomy and in combination with electrical stimulation of the peripheral ends...

...Marcello Ferrari; Mario Olivieri; Guido Lampronti; Cristina Biasin; Vincenzo Lo Cascio This study investigated whether or not a sustained release formulation of theophylline (SRT) at different dosages had any effect on bronchial hyperresponsiveness as measured by the methacholine challenge. On four...

... and methacholine have been the most widely used inhalation tests. Recently, propranolol, given by inhalation, has been proposed and evaluated for possible application as a bronchial provocation challenge both in clinical and experimental setting. In asthmatic subjects with bronchial hyperresponsiveness...

...Tahir Ahmed; Ignacio Danta We studied the comparative modification of histamine- and methacholine-induced bronchoconstriction by a calcium antagonist, gallopamil, in 8 subjects with bronchial asthma. Dose-response curves to aerosolized methacholine or histamine were performed, without and following...

...Y. Ploysongsang; R.P. Baughman; R.G. Loudon; M.C. Rashkin We recorded wheezes, pleural pressure, plethysmographic lung volumes and mouth flow rates in 6 healthy subjects during maximal expiratory maneuvers breathing air and a mixture of 80% He-20% O 2 (He) before and after methacholine inhalation...

...Frederick E. Hargreave; Peter Sterk; Ellinor C. Adelroth; Helen Ramsdale; Paul M. O’Byrne A number of topical aspects of histamine or methacholine inhalation tests were discussed. First, the reporting of results as the dose delivered to the mouth by the method of aerosol generation and inhalation...

...Miguel Perpiñá; Concha Pellicer; Vicente Marco The protective effect of the calcium antagonist nifedipine (20 mg sublingually) on methacholine-induced bronchospasms was investigated in 14 mild asthmatics, 8 extrinsic and 6 intrinsic, in stable situations and with FEV 1 ≥80% of the one predicted...

...Yvon Cormier; Jacques Bélanger; Alain Côté We studied 10 normal volunteers with single-breath nitrogen tests before and after methacholrne-induced bronchoconstriction. On the first day we challenged each subject with increasing methacholine concentrations to obtain a 20% drop in the partial forced...

... challenge with methacholine. The results of the specific bronchial provocation test were well reproducible, with similar coefficients of variation for both early and late reactions. The specific bronchial provocation test was found to be more related to the allergic status, as reflected by specific IgE...

...Vito Brusasco; Danilo Rocchi The behavior of maximum expiratory flow-volume curves and partial expiratory flow-volume curves with and without volume history of total lung capacity was studied in 11 healthy subjects before and after methacholine inhalation challenge. Flow-volume curves were...

... pressurised metered-dose inhaler (pMDI) with spacer in patients with BHR. Methods: A randomised, double-blind, crossover study was carried out in a group of 27 patients (aged 19–55 years) with a clinical diagnosis of reversible airway disease, who demonstrated BHR to methacholine (PD 20 ≤6.4 mg). Each patient...

... hyperresponsiveness (AHR) which is usually assessed as response to inhaled methacholine is the most characteristic feature of asthma. AHR is reported in chronic obstructive pulmonary disease patients and smokers, and may also show in chemical warfare victims. However, there are little reports regarding AHR...

... hyperresponsiveness. Information is not univocal about the potential effects of prolonged exposure to environmental air pollutants on lung function. Objectives: A cross-sectional study was performed to assess bronchial responsiveness to methacholine in children living in an air-polluted area. Afterwards, the same...

...). Objective: Our study was designed to investigate whether oral pretreatment with zafirlukast (a cys-LTs receptor antagonist) reduces bronchoconstriction against methacholine (MC) and ultrasonically nebulized distilled water (UNDW) challenge in patients with mild asthma. Methods: Fourteen non-atopic patients...

... (before methacholine) and recovery from the lowest value in FEV 1 evoked by the methacholine challenge (after methacholine). After the first study, 400 µg of beclomethasone dipropionate (BDP) was administered twice daily for 1 week to all patients, and the above-mentioned protocols were repeated. Results...

... and methacholine. The response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall in FEV 1 (PC 20 ). Results: The geometric mean PC 20 acetaldehyde value for asthmatics was 35.5 mg/ml compared with 67.6 mg/ml in subjects with allergic rhinitis...

... hyperresponsiveness (BH) in CS without any apparent lower airway disease is not fully understood nor are the effects of treatment. We examined lower airway hyperresponsiveness to methacholine (MCh) in 42 subjects with CS but without allergic rhinitis (AR) who had normal lung functions without any pulmonary symptoms...