... are able to synthesize and release chemical mediators involved in the pathophysiology of bronchial asthma; they can be activated by an IgE dependent mechanism, phagocytosed particles (zymosan and opsonized zymosan) or soluble stimuli such as a chemoattractant peptide (fMLP) or a potent activator of protein...

...Stephen C. Lazarus Mast cells produce a variety of enzymes and vasoactive, chemotactic, and bronchoconstrictor substances in response to nonimmunologic as well as immunologic stimuli. These mast cell-derived mediators may act on airway smooth muscle, submuco-sal glands, epithelial cells...

..., characterized by elevated levels of certain potent pro-inflammatory mediators, such as C-reactive protein, leptin, TNF-α, IL-1β, IL-6, reactive oxygen species and adhesion molecules, may predispose to the development of cardiovascular complications observed in patients with OSAS. Treatment with nasal CPAP...