...Sissel Kronborg-White; Elisabeth Bendstrup; Line Bille Madsen; Finn Rasmussen; Venerino Poletti Background: Mediastinal lymph node enlargement (MLNE) is a finding described in a subset of patients with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs) and is associated...

...Michele Mondoni; Fausta Alfano; Francesco Varone; Giuseppe Muscato; Caterina Conti; Laura Saderi; Amerigo Chiesa; Fabiano Di Marco; Carlo Vancheri; Luca Richeldi; Stefano Centanni; Giovanni Sotgiu Background: Idiopathic pulmonary fibrosis (IPF) primarily affects old patients. Old age is a predictor...

...Sergio Harari; Alberto Pesci; Carlo Albera; Venerino Poletti; Christian Amici; Giovanna Crespi; Benedetta Campolo; Carlo Vancheri; on behalf of the FIBRONET study group Background: The FIBRONET study was an observational study of patients with idiopathic pulmonary fibrosis (IPF) in Italy...

..., instructions or products referred to in the content or advertisements. Pulmonary fibrosis Interstitial lung disease Seasonality Hospitalizations Idiopathic pulmonary fibrosis Interstitial lung disease (ILD) is a term comprising numerous chronic lung diseases which primarily involve the lung...

...Stéphane Jouneau; Bruno Crestani; Ronan Thibault; Mathieu Lederlin; Laurent Vernhet; Ming Yang; Elizabeth Morgenthien; Klaus-Uwe Kirchgaessler; Vincent Cottin Background: Weight loss is frequently reported in patients with idiopathic pulmonary fibrosis (IPF) and may be associated with worse...

... Chevereau; Isabelle Dufaure-Garé; Serge Amselem; Annick Clement; the OrphaLung and RespiFil Networks Background: There is growing evidence of gender-specific phenotypic differences among patients with idiopathic pulmonary fibrosis (IPF), which may affect patient outcomes. Objectives: We present...

...Kazuya Shingai; Toshiaki Matsuda; Yasuhiro Kondoh; Tomoki Kimura; Kensuke Kataoka; Toshiki Yokoyama; Yasuhiko Yamano; Tomoya Ogawa; Fumiko Watanabe; Jun Hirasawa; Ryo Kozu Background: Although physical activity is associated with mortality in patients with idiopathic pulmonary fibrosis (IPF...

...Catharina C. Moor; Nelleke C. Tak van Jaarsveld; Catherine Owusuaa; Jelle R. Miedema; Sara Baart; Carin C.D. van der Rijt; Marlies S. Wijsenbeek Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fatal disease with a heterogeneous disease course. Timely initiation of palliative care...

...Arnaud Fedi; Sophia Keddache; Sébastien Quétant; Alicia Guillien; Anestis Antoniadis; Thibaud Soumagne; Ophélie Ritter; Jean-Charles Glérant; Vincent Cottin; Bruno Degano; Bernard Aguilaniu Background: In idiopathic pulmonary fibrosis (IPF), some physiological parameters measured during a 6-min...

...Konstantina Dipla; Afroditi K. Boutou; Aikaterini Markopoulou; Georgia Pitsiou; Stavros Papadopoulos; Anastasia Chatzikosti; Ioannis Stanopoulos; Andreas Zafeiridis Background: In patients with idiopathic pulmonary fibrosis (IPF) with isolated exertional desaturation, there are limited data...

... Müller-Quernheim; Ulrich Costabel Idiopathic pulmonary fibrosis (IPF) is a severe and often fatal disease. Diagnosis of IPF requires considerable expertise and experience. Since the publication of the international IPF guideline in the year 2011 and the update 2018 several studies and technical advances...

...Sergio Harari; Claudia Specchia; Roberto Lipsi; Roberto Cassandro; Antonella Caminati Background: Two pharmaceutical agents have been approved for treatment of idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Objectives: We investigated the need of dose reduction in consecutive...

...Kathleen M. Mortimer; Dorothee B. Bartels; Nadine Hartmann; Jorge Capapey; Jing Yang; Robert Gately; Cheryl Enger Background: Idiopathic pulmonary fibrosis (IPF) is a life-threatening interstitial lung disease (ILD). Characterizing health outcomes of IPF patients is challenging due to disease...

..., it is associated with significant morbidity and mortality rates [ 4 ] and is especially problematic in patients with severe physiological impairment or substantial comorbidities [ 1 ]. Transbronchial cryobiopsy Lung explant Idiopathic pulmonary fibrosis Usual interstitial pneumonia Diagnosis Fig. 1...

...Min Song; Hong Peng; Wei Guo; Man Luo; Wang Duan; Ping Chen; Yong Zhou Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrotic lung disease with an unknown aetiology. Persistent myofibroblast differentiation is a prominent feature of IPF. Cigarette smoking is a risk...

... evaluated the long-term safety of pirfenidone under real-world conditions in idiopathic pulmonary fibrosis (IPF), over up to 2 years following its initiation. Objectives: The FAS (French Ancillary Study) assessed the clinical outcomes of IPF patients participating in PASSPORT ( n = 192). Methods: Efficacy...

...Elisabeth Bendstrup; Wim Wuyts; Tiago Alfaro; Nazia Chaudhuri; Robin Cornelissen; Michael Kreuter; Kirsten Melgaard Nielsen; Anna-Marie B. Münster; Marjukka Myllärniemi; Claudia Ravaglia; Tim Vanuytsel; Marlies Wijsenbeek Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal...

...Hee-Young Yoon; Dong Soon Kim; Jin Woo Song Background: Although phase 3 trials showed significant efficacy and acceptable safety profiles for pirfenidone in mild-to-moderate idiopathic pulmonary fibrosis (IPF), data on advanced IPF are limited. Objectives: The study aimed to evaluate the efficacy...

...Zheng Wang; Francesco Bonella; Wenting Li; Eda B. Boerner; Qiongya Guo; Xianglong Kong; Xiaoju Zhang; Ulrich Costabel; Michael Kreuter The mechanisms of idiopathic pulmonary fibrosis (IPF), a rare, devastating disease with a median survival of 3–5 years, are not fully understood. Gastroesophageal...

... of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index of nutrition status, can detect the malnutrition more accurately than the conventional single-point body mass index evaluation. Objective: To investigate how the temporal BW change...