...Nikolaos Manitsopoulos; Ioanna Nikitopoulou; Nikolaos A. Maniatis; Christina Magkou; Anastasia Kotanidou; Stylianos E. Orfanos Background: Pulmonary fibrosis is a chronic disease, which progressively leads to respiratory failure and ultimately death. Endothelin-1 (ET-1), a vasoconstrictor secreted...

... higher peripheral O 2 extraction; this is probably due to their larger muscle mass. Objectives: The aim of this study was to examine this phenomenon by measuring 2 vasoactive substances, endothelin-1 (ET-1) and nitric oxide (NO), during a progressive submaximal exercise. Methods: Seventeen obese (body...

...Corey E. Ventetuolo; Steven M. Kawut; David J. Lederer Background: Pulmonary hypertension (PH) is associated with a poor prognosis in idiopathic pulmonary fibrosis (IPF). Endothelin-1 (ET-1) and vascular endothelial growth factor (VEGF) are important in both fibrosis and vascular remodeling...

... of the study was to determine the effect of omalizumab treatment on changes in endothelin-1 (ET-1), which plays an important role in the development of airway inflammation and remodeling in exhaled breath condensate (EBC) in patients with severe asthma. Methods: The study was conducted in a group of 19...

...Matteo Sofia; Mauro Mormile; Stanislao Faraone; Pierluigi Carratù; Marco Alifano; Giuseppe Di Benedetto; Luigi Carratù Abnormalities in endothelin-1 (ET-1) pulmonary metabolism have been reported in patients with pulmonary hypertension, asthma and chronic obstructive pulmonary disease (COPD...

... genistein. Furthermore, examination of expression in endothelial nitric oxide synthase and endothelin-1 peptide level was performed. Methods: Daily supplementation with either genistein (0.2 mg/kg) or vehicle was started 2 days prior to a single-dose injection of MCT (60 mg/kg). On day 28, rats underwent...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sarcoidosis Pulmonary hypertension Endothelin-1 Bosentan Sarcoidosis is a multisystemic disease of undetermined etiology that predominantly affects the respiratory...

... 1988;332:411–415. 2. Redington AE, Springall DR, Ghatei MA, et al: Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am J Respir Crit Care Med 1995;151:1034–1039. 3. Hay DW: Putative mediator role of endothelin-1 in asthma and other lung diseases. Clin...

...). It is also known that endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by the pulmonary vascular endothelium, and ET-1 may be implicated in the pathogenesis of PH. Objectives: The purpose of this study was to investigate the presence of ET-1 in patients with COPD and to assess the correlation...

... of this study was to investigate the presence of two profibrotic markers, the vitronectin and the endothelin-1 (ET-1) in the airways of NSIP and FASSc patients. Methods: Ten NSIP (6 males, age 57 ± 2 years) and 15 FASSc (8 males, age 55 ± 4 years) patients were recruited along with 10 normal subjects (4 male...

...G. Trakada; M. Marangos; K. Spiropoulos Background: Nonapneic, oxyhemoglobin desaturation associated with sleep has been described in patients with chronic obstructive pulmonary disease (COPD). Hypoxemia stimulates endothelin-1 (ET-1) secretion. Once released, ET-1 can act locally to elicit...

...Tatsuo Fujii; Toshihiro Otsuka; Shigehiro Tanaka; Hiroshi Kanazawa; Kazuto Hirata; Masakazu Kohno; Naotsugu Kurihara; Junichi Yoshikawa Background and Objective: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by the vascular endothelium. The purpose of this study was to elucidate...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Endothelin-1 Serotonin Smooth muscle contraction Trachea Protein kinase C Basic Science Investigations Respiration 1999;66:59 64 Received: February 2, 1998 Accepted after revision: July 14, 1998...

...Gülfem Çelik; Gülseren Karabiyikoglu Endothelin-1 (ET-1) has been described to have crucial effects in the initiation and evolution of pulmonary hypertension (PH) secondary to cardiac disorders. However, the precise role of ET-1 in PH induced by chronic obstructive pulmonary disease (COPD...