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Keywords: Desensitization
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Journal Articles

Treatment with High Doses of Terbutaline Induces β-Adrenergic Desensitization of Guinea Pig Trachea Not Prevented by the Addition of Dexamethasone

Subject Area:
Pharmacology , Pneumology
A.J. Seco, M.E. Salgueiro, M.A. Villanueva, G. Manso
Journal: Respiration
Respiration (2000) 67 (5): 559–564.
https://doi.org/10.1159/000067474
Published Online: 18 October 2000
... agonists in guinea pig trachea. Results: Terbutaline (100 mg/kg/day), for 7 days, induced a marked homologous desensitization. The addition of dexamethasone (0.2 or 2 mg/kg/day) to the treatment did not prevent the development of desensitization, which was even more marked in the group treated...
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