...Aldo Kammerlander; Simon Raphael Schneider; Michael Furian; Esther Irene Schwarz; Mona Lichtblau; Silvia Ulrich; Julian Müller Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and contributes significantly to reduced quality of life...

.... 2025 Chronic obstructive pulmonary disease PDE3 and PDE4 Anti-inflammatory drugs Ensifentrine RPL554 Phosphodiesterase inhibitors Inhibitors of phosphodiesterase (PDE)3 and PDE4 have been shown to demonstrate pharmacologically relevant activity for the treatment of obstructive...

...Stavros Tryfon; Efthymia Papadopoulou; Polyanthi Papanastasiou; Alexandros Ginis; Konstantinos Kostikas Introduction: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. Prevention of exacerbations is fundamental to COPD management. Methods...

...Emanuela Resta; Giusi Graziano; Giacomo Riformato; Chiara Noviello; Silvio Tafuri; Paola Pierucci Introduction: Natural history of chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in pulmonary function and recurrent exacerbations, requiring frequent hospital...

...Morten Borg; Rikke Ibsen; Ole Hilberg; Anders Løkke Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, characterized by airflow limitation and lung hyperinflation due to emphysema. Bronchoscopic lung volume reduction (BLVR) with endobronchial...

... (−5.0 pts [2.8–7.3], p = 0.006) or anxiety symptoms (−4.8 pts [2.1–7.5], p = 0.008) only after HIT (online suppl. Table S3). The effectiveness of exercise training in patients with chronic obstructive pulmonary disease (COPD) is well documented and proven with the highest level of evidence [ 1...

...Carlos J. Alvarez-Martinez; Jorge Vélez; Clara Goñi; Joaquín Sánchez-Covisa; Mónica Juárez-Campo; Luciano Escudero; José L. Bernal; Nicolás Rosillo; Miguel Hernández; Héctor Bueno Introduction: The change in prevalence and management of chronic obstructive pulmonary disease (COPD) led to changes...

...Junjie Peng; Xiaohua Li; Hong Zhou; Tao Wang; Xiaoou Li; Lei Chen Introduction: Impulse oscillometry (IOS) is an effortless test compared to spirometry. Numerous studies explored the role of IOS in spirometry-based chronic obstructive pulmonary disease (COPD), but most of them had limited sample...

... ]. The introduction of bronchoscopic lung volume reduction (BLVR) treatments has broadened the therapeutic options for patients with severe chronic obstructive pulmonary disease (COPD) with an emphysematous phenotype and substantial static lung hyperinflation. Currently, the most established BLVR approach is the use...

... of this study was to apply quantitative computed tomography (QCT) for GOLD-grade specific disease characterization and phenotyping of air-trapping, emphysema, and airway abnormalities in patients with chronic obstructive pulmonary disease (COPD) from a nationwide cohort study. Methods: As part of the COSYCONET...

...Judith Elshof; Eline Oppersma; Jantine J. Wisse; Gerrie Bladder; Petra M. Meijer; Abel Torres; Peter J. Wijkstra; Marieke L. Duiverman Introduction: Patients with chronic obstructive pulmonary disease (COPD) commonly experience severe dyspnea after discontinuation of nocturnal noninvasive...

...Shengchuan Feng; Ran Zhang; Wenxiu Zhang; Yuqiong Yang; Aiqi Song; Jiawei Chen; Fengyan Wang; Jiaxuan Xu; Cuixia Liang; Xiaoyun Liang; Rongchang Chen; Zhenyu Liang Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) have a significant impact on hospitalizations, morbidity...

...Jonas Herth; Jasmin Wani; Daniel Franzen Introduction: Bronchoscopic lung volume reduction (BLVR) using endobronchial coil treatment is a widely studied therapeutic option in patients with end-stage chronic obstructive pulmonary disease (COPD) and pulmonary emphysema. However, patient responses...

...Judith Maria Brock; Christina Rott; Eldridge Frederick Limen; Konstantina Kontogianni; Daniela Gompelmann; Felix J.F. Herth Introduction: Patients with chronic obstructive pulmonary disease (COPD) and emphysema experience malnutrition and pulmonary cachexia. Endoscopic lung volume reduction (ELVR...

...Cristina Aljama; Galo Granados; Marian Ramon; Miriam Barrecheguren; Eduardo Loeb; Alexa Nuñez; Eulogio Pleguezuelos; Francisco García-Río; Marc Miravitlles Introduction: Physical activity (PA) has shown great benefits in patients with chronic obstructive pulmonary disease (COPD); however, their PA...

...Guangsheng Pei; Liyan Guo; Siqiao Liang; Fugang Chen; Nan Ma; Jing Bai; Jingmin Deng; Meihua Li; Chunhai Qin; Tao Feng; Zhiyi He Introduction: Although long-term macrolide antibiotics could reduce the recurrent exacerbation of chronic obstructive pulmonary disease (COPD), the side effect...

...Jingwei Liu; Difei Chen; Yanhui Yu; Yu Deng; Ruijin Lu; Jing Zhang; Shiyue Li Introduction: Endoscopic lung volume reduction with endobronchial valves has been widely recognized for treating hyperinflation in advanced chronic obstructive pulmonary disease and emphysema patients. The main challenges...

...Na Young Kim; Junhee Han; Yong Il Hwang; Yong Bum Park; Seoung Ju Park; Jimyung Park; Ki-Suck Jung; Kwang Ha Yoo; Jin Hwa Lee; Chang Youl Lee Introduction: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) score is widely used for evaluating the health status of patients...

... prospective studies will be necessary to understand the significance of the association. Mental health disorders figure among the many comorbidities of chronic obstructive pulmonary disease (COPD) and asthma. Major depressive disorder and anxiety disorders account for approximately 60% of all mental...

... or longer, with available blood EOS counts. Full inclusion and exclusion criteria have been described previously [ 16, 17 ]. Epidemiology Blood eosinophil Chinese general population Smoking Chronic obstructive pulmonary disease As a subtype of leukocyte, eosinophil (EOS) is involved...