... by endothelial cells, promotes vasoconstriction by activation of its receptors A and B. Objectives: We addressed the role of highly selective ET-1 receptor A (ETA) inhibition in the pathogenesis of experimental pulmonary fibrosis by bleomycin (BLM). Methods: BLM sulfate (2 U/mL) or saline was intratracheally...

... of injury. Objectives: The aim of this study was to determine the effect of the mobilization of autologous bone marrow-derived cells by granulocyte colony-stimulating factor (CSF3) on bleomycin-induced lung injury in mice. Methods: The bone marrow from male green fluorescent protein transgenic (C57Bl/6J...

... with ambroxol was accompanied by alveolar macrophage activation and a shift of the alveolar elastase/antielastase balance towards increased antielastase activity, and (2) in bleomycin-treated rats alveolar phospholipidosis was obvious 14 days after drug administration, ambroxol protection reduced...

...E. Pozzi; M. Salmona; P. Masturzo; M. Genghini; M. Scelsi; L. Spialtini; M. Luisetti The events leading to the onset of the experimental bleomycin-induced pulmonary fibrosis are so far unknown, though recent observations emphasize the crucial role played by lung phospholipids and by alveolar...

... regarding these functions in human adult lung diseases and results of investigations of surfactant in an animal model of bleomycin-induced lung fibrosis are presented. 16 1 2009 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...Hong Wei Yao; Jian Ping Zhu; Meng Hui Zhao; Yuan Lu Background: In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system is also involved in lung fibrogenesis. Objective: To study the effect of losartan, an angiotensin II antagonist, on bleomycin-induced...

...Izidore S. Lossos; Reuven Or; Vallery Ginzburg; Thomas G. Christensen; Yaffa Mashriki; Raphael Breuer Background: Intratracheal instillation of bleomycin (Bleo) into rodents serves as a model for human lung fibrosis. Various mouse strains respond differently to Bleo, and BALB/c mice are relatively...

...N. Berkman; S. Kremer; R. Or; I.S. Lossos; T.G. Christensen; R.H. Goldstein; R. Breuer Background: Bleomycin (Bleo)-induced lung injury in mice serves as an animal model of pulmonary fibrosis. The pathogenesis of pulmonary fibrosis remains unclear, but it comprises both inflammatory and fibrotic...

...S. Kremer; R. Breuer; I.S. Lossos; N. Berkman; T.G. Christensen; M.W. Connor; R.H. Goldstein; R. Or Background: The role of lymphocytes and their subpopulations in lung fibrosis is as yet unclear. Objective: To define the role of immunomodulation in bleomycin-induced inflammatory fibrotic lung...