...Mario Polverino; Simone Sampaolo; Antonio Capuozzo; Marco Fasolino; Michele Aliberti; Ersilia Satta; Carlo Santoriello; James Peter Orengo; Francesca Polverino Background: The current diagnostic criteria for amyotrophic lateral sclerosis (ALS) may remain unsatisfactory for months or years...

.... Respiratory muscle strength Chronic respiratory failure Sniff nasal inspiratory pressure Mouth maximal inspiratory pressure Motor neuron disease Amyotrophic lateral sclerosis Motor neuron disease (MND) encompasses a group of neurodegenerative diseases (mainly amyotrophic lateral sclerosis; ALS...

... assessment of hypoventilation in NMD [ 14 ]. In rapidly progressive NMD, monitoring pulmonary function tests (PFTs) every 3–4 months is crucial for assessing respiratory muscle impairment progression, i.e., amyotrophic lateral sclerosis (ALS) [ 10 ]. The most recent guidelines [ 10-12 ] proposed...

...Michael S. Sherman; Harold L. Paz Respiratory failure is the leading cause of death in patients with amyotrophic lateral sclerosis (ALS). We review the physiology of respiratory compromise in ALS and techniques of monitoring respiratory function. Treatment options, including pharmacologic...