... to altitude have not been assessed despite an increasing prevalence of the disease. Objectives: We hypothesized that pulmonary artery pressure (PAP) significantly increases and cardiac function deteriorates during exposure to hypobaric hypoxia as encountered by traveling to moderate altitude or air flight...

...Michael Furian; Sara E. Hartmann; Tsogyal D. Latshang; Deborah Flueck; Christian Murer; Philipp M. Scheiwiller; Batyr Osmonov; Silvia Ulrich; Malcolm Kohler; Marc J. Poulin; Konrad E. Bloch Background: Effects of hypobaric hypoxia at altitude on exercise performance of lowlanders with chronic...

.... Altitude Cardiac output Exercise Pulmonary diffusing capacity Type 1 diabetes mellitus National Institutes of Health (NIH) 10.13039/100000002 The American Diabetes Association recommends that people with type 1 diabetes (T1D) engage in physical activity [ 1,2 ]. It is unclear whether...

...Shmuel Goldberg; Eadit Buhbut; Francis B. Mimouni; Leon Joseph; Elie Picard Background: Arterial hemoglobin oxygen saturation (Sa O 2 ) decreases at an altitude of >1,500 m. There are no reports on normal Sa O 2 at altitudes between 0 and 1,500 m. The clinical significance of decreased Sa O 2...

...Robert Naeije Hypoxia constricts the pulmonary vessels. An increase in pulmonary vascular resistance is seen in normal subjects during hypoxic breathing at sea level, in acclimatized lowlanders and in high-altitude natives. Hypoxic pulmonary hypertension in all these circumstances is most generally...

...Kevin J. Greenlees; Alan Tucker Male Sprague-Dawley rats were exposed to 6, 3 or 1 h of simulated high altitude (380 Torr). The isolated perfused lung of each animal was challenged with 4 sequential periods of hypoxia, angiotensin II (All), and 5-hydroxytryptamine (5-HT) following altitude exposure...

...B. Hartmann; M. Unger; M. Debelić; P. Hilpert In 49 patients with obstructive airways disease and 15 normal subjects O 2 and CO 2 tension in arterial blood, vital capacity, maximal midexpiratory flow rate and forced expiratory volume were studied at 524, 1,600, and 2,844 m altitude...

...S.K. Kwatra; R. Viswanathan Furosemide which is claimed to prevent acute mountain sickness and pulmonary oedema of high altitude was tried in experimental animals to evaluate its usefulness or otherwise as a measure of prophylaxis. 90 mice, 128 rats and 44 guinea pigs – all males – were used...

...R. Viswanathan; S. Subramanian; S.T.K. Lodi; T.G. Radha 101 Indian soldiers, 57 of whom had developed pulmonary oedema of high altitude (POHA) and 44 who had not developed this condition in spite of being at high altitudes for over 2 years, were investigated for observing the differences, if any...

...Juan-Carlos Vázquez; Rogelio Pérez-Padilla Objective: To investigate the impact of oxygen on sleep and breathing in patients with interstitial lung disease (ILD) in Mexico City, at 2,240 m of altitude. Participants: Nineteen ILD patients with a mean FVC of 58 ± 17% pred. (SD) and a mean PaO 2 of 51...