... , Kerstjens   HA , Gosens   R . Anti-inflammatory effects of targeted lung denervation in patients with COPD . Eur Respir J . 2015 Nov ; 46 ( 5 ): 1489 – 92 . 10.1183/13993003.00413-2015 . 25. Kistemaker   LE , Gosens   R . Acetylcholine beyond bronchoconstriction: roles...

.... Bronchoscopy Radiofrequency ablation Parasympathectomy Lung disease obstructive Acetylcholine Acetylcholine released from parasympathetic nerves in the lung is a key mediator of pathology in obstructive airways diseases through its induction of smooth muscle contraction, facilitation of reflex...

... inoculation, airway responsiveness to inhaled acetylcholine (ACH) aerosol was measured in anesthetized and tracheotomized guinea pigs. The ACH concentration which produced an increase of 100% in pulmonary resistance (PC 100 RI ) and in dynamic elastance (PC 100 Edyn ) was calculated from a 5-step ACH dose...

...W. Marek; X. Baur; W.T. Ulmer Immediate airway reactivity to Ascaris suum allergen was compared with the responses to nonallergic airway challenge using histamine and acetylcholine in sheep with positive skin reactions to the allergen. In a control group of 6 sheep with negative skin test responses...

...H. Aizawa; H. Inoue; T. Ikeda; T. Hirose; Y. Ito It has been reported that low concentrations of noradrenaline or isoprenaline reduce the resting tension of the smooth muscle cells and suppress acetylcholine release from the vagal nerve terminals through activation of β 2 -adrenoceptors. Procaterol...

...F. Gimeno; G.H. Koëter; J.G.R. de Monchy; R. van Altena A retrospective study was performed to evaluate the diagnostic yield for bronchial hyperresponsiveness from histamine and acetylcholine challenge tests. The records of 180 cases from the last 10 years were analysed. They were selected because...

... smooth muscle contraction) of capsaicin (10 -8 to 10 -7 M) increased the amplitudes of contractions evoked by electrical field stimulation (EFS) significantly, but not those by acetylcholine (ACh). The inhibitor of neutral endopeptidase, phosphoramidon (10 -7 to 10 -6 M), increased the contractions...

...Jolanta Jackowski; Gillette A. Chapman; William M. Abraham; Tahir Ahmed We compared the inhibitory effects of calcium channel blockers, gallopamil and verapamil on acetylcholine (Ach)-induced contractions of ovine tracheal muscle in vitro. Adult sheep were sacrificed and tracheal strips were...

...J.L. Ortiz; C. Labat; X. Norel; M.G. Matera; J. Cortigo; E. Morcillo; F. Rossi; C. Brink The influence of the epithelium on the contractile responses of bovine bronchial rings to acetylcholine, carbachol, 5-hydroxytryptamine and histamine was studied. Epithelium removal caused a significant...

..., a slow calcium channel blocker, would inhibit or attenuate acetylcholine-induced bronchoconstriction in asthmatics. Because one consequence of mast cell activation is the release of platelet-activating factor, we wondered whether thromboxane levels would be increased during acute bronchial constriction...

... on contractions of lung parenchymal strips induced by various agonists (CaCl 2 , KC1, acetylcholine and histamine) in control (unsensitized) and actively sensitized guinea pigs. Concentration-response curves to CaCl 2 were constructed in the presence of a depolarizing (K + 30 mM) Ca 2+ -free Tris-physiological...

...Shinichi Tomioka; Munehiro Arai; Hajime Kuroiwa; Ryuzo Fueki; Setsuo Kobayashi We have investigated the effect of nifedipine on acetylcholine-induced bronchoconstriction in 8 asthmatics and on histamine-induced bronchoconstriction in another 8 asthmatics on a single-blind basis. Expiratory...

...Peter Bánovčin; Peter Višňovský; Ján Hanáček; Juraj Korpáš The reactivity of cat lung parenchymal strips to histamine and acetylcholine in vitro was studied at various stages of inflammation of the airways induced experimentally by the intratracheal administration of turpentine oil...

...I. Zimmermann; B.A. Peskar; B. Rasche; W.T. Ulmer; A.A. Bugalho de Almeida In three series of experiments, aerosols of acetylcholine, histamine, and Ascaris were administered in a maximal concentration before and after bilateral vagus transection. Vagotomy induced a clear reduction of the dynamic...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acetylcholine Allergen Bronchoconstriction Syncytial connection Transection of tracheal wall Respiration 46: 76-81...

...Angel Casacó; Ricardo González; Lourdes Arruzazabala; Milagros García; Adolfo R. de la Vega Kerosene aerosol (32.5 mg/l; 20 min), when administered to guinea pigs 1 h before exposure to acetylcholine (Ach), induced potentiation of cumulative dose-response curve of this agonist on isolated tracheal...

...G.H. Koëter; H. Meurs; J.H.G. Jonkman; K. de Vries The protective effect of choline theophyllinate, 600 mg orally, was studied by examining the effects on inhaled histamine, acetylcholine, and propranolol in 19 asthmatic patients. Only 9 of them showed a propranolol threshold. This bronchodilator...

...W.T. Ulmer; M.S. Islam The experiments on dogs show that the bronchoconstriction after acetylcholine inhalation is caused by a reflex mechanism mediated via sensory receptors and N. vagi. Blockade of the N. vagi with low concentration of Novocain does not affect tidal volume and frequency...

... of acetylcholine for bronchoconstriction by allergic mechanism is discussed 2 11 1973 20 11 1973 14 1 2009 © 1974 S. Karger AG, Basel 1974 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

...Eckhard Kaukel; Karlgeorg Lanser; Norbert Völkel; Wolfgang Beier; Volker Sill In anesthetized, spontaneously breathing rabbits, intratracheally administered isotonic saline, acetylcholine (Ach) and histamine (His) induced an increase of airway resistance up to 183, 571, and 312%, respectively...